Incidental Mutation 'IGL02276:Iigp1c'
| ID |
287332 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Iigp1c
|
| Ensembl Gene |
ENSMUSG00000073555 |
| Gene Name |
interferon inducible GTPase 1C |
| Synonyms |
Gm4951 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02276
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
18 |
| Chromosomal Location |
60345152-60380892 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 60379151 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 229
(I229F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031549
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031549]
|
| AlphaFold |
Q3UED7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031549
AA Change: I229F
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: I229F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
34 |
402 |
4.8e-157 |
PFAM |
|
Pfam:MMR_HSR1
|
70 |
198 |
2.8e-8 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy10 |
T |
C |
1: 165,386,697 (GRCm39) |
V1140A |
probably damaging |
Het |
| Ccdc88b |
A |
G |
19: 6,833,475 (GRCm39) |
|
probably null |
Het |
| Cep135 |
A |
G |
5: 76,782,093 (GRCm39) |
N904S |
probably benign |
Het |
| Dnajc12 |
G |
A |
10: 63,244,037 (GRCm39) |
R109Q |
probably damaging |
Het |
| Dpp4 |
A |
G |
2: 62,187,295 (GRCm39) |
|
probably benign |
Het |
| Duox2 |
A |
T |
2: 122,124,566 (GRCm39) |
N380K |
probably benign |
Het |
| Dusp11 |
A |
T |
6: 85,935,599 (GRCm39) |
D91E |
probably damaging |
Het |
| Fkbp15 |
C |
A |
4: 62,254,703 (GRCm39) |
E266* |
probably null |
Het |
| Gm10337 |
A |
G |
15: 102,412,169 (GRCm39) |
V324A |
probably damaging |
Het |
| Grik3 |
A |
T |
4: 125,517,295 (GRCm39) |
D46V |
possibly damaging |
Het |
| Hdac9 |
G |
A |
12: 34,481,925 (GRCm39) |
T181I |
probably damaging |
Het |
| Large1 |
T |
A |
8: 73,544,721 (GRCm39) |
M686L |
probably benign |
Het |
| Lca5 |
C |
A |
9: 83,280,638 (GRCm39) |
L387F |
possibly damaging |
Het |
| Mtmr9 |
A |
T |
14: 63,767,725 (GRCm39) |
W295R |
probably damaging |
Het |
| Or2h15 |
A |
G |
17: 38,441,484 (GRCm39) |
S200P |
probably damaging |
Het |
| Or5ac15 |
A |
C |
16: 58,940,378 (GRCm39) |
D18E |
probably benign |
Het |
| Phf20l1 |
T |
A |
15: 66,487,259 (GRCm39) |
|
probably null |
Het |
| Plce1 |
A |
G |
19: 38,513,201 (GRCm39) |
S167G |
probably benign |
Het |
| Plekha6 |
C |
A |
1: 133,221,599 (GRCm39) |
D934E |
possibly damaging |
Het |
| Pramel17 |
T |
C |
4: 101,695,306 (GRCm39) |
S2G |
possibly damaging |
Het |
| Ptpn6 |
A |
C |
6: 124,705,828 (GRCm39) |
D105E |
probably null |
Het |
| Rtp1 |
T |
C |
16: 23,250,063 (GRCm39) |
S143P |
probably benign |
Het |
| Rttn |
A |
C |
18: 89,066,578 (GRCm39) |
Q1208P |
possibly damaging |
Het |
| Snx27 |
A |
T |
3: 94,438,686 (GRCm39) |
V183D |
probably damaging |
Het |
| Stim2 |
T |
C |
5: 54,210,712 (GRCm39) |
|
probably benign |
Het |
| Trak1 |
A |
T |
9: 121,280,734 (GRCm39) |
E271D |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,774,226 (GRCm39) |
|
probably benign |
Het |
| Vmn2r4 |
G |
A |
3: 64,313,877 (GRCm39) |
T279I |
possibly damaging |
Het |
| Vmn2r73 |
A |
T |
7: 85,518,980 (GRCm39) |
|
probably null |
Het |
| Zfp819 |
G |
A |
7: 43,261,428 (GRCm39) |
V32I |
possibly damaging |
Het |
|
| Other mutations in Iigp1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00717:Iigp1c
|
APN |
18 |
60,379,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Iigp1c
|
APN |
18 |
60,378,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00956:Iigp1c
|
APN |
18 |
60,379,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Iigp1c
|
APN |
18 |
60,378,508 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01929:Iigp1c
|
APN |
18 |
60,379,554 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02267:Iigp1c
|
APN |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02499:Iigp1c
|
APN |
18 |
60,378,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02538:Iigp1c
|
APN |
18 |
60,378,944 (GRCm39) |
nonsense |
probably null |
|
|
IGL03139:Iigp1c
|
APN |
18 |
60,379,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03209:Iigp1c
|
APN |
18 |
60,379,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Iigp1c
|
APN |
18 |
60,378,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03325:Iigp1c
|
APN |
18 |
60,378,883 (GRCm39) |
nonsense |
probably null |
|
|
Carboniferous
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Oily
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Iigp1c
|
UTSW |
18 |
60,378,489 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2046:Iigp1c
|
UTSW |
18 |
60,378,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2296:Iigp1c
|
UTSW |
18 |
60,378,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4583:Iigp1c
|
UTSW |
18 |
60,379,152 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5500:Iigp1c
|
UTSW |
18 |
60,379,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5532:Iigp1c
|
UTSW |
18 |
60,379,142 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5938:Iigp1c
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6446:Iigp1c
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7191:Iigp1c
|
UTSW |
18 |
60,379,329 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7238:Iigp1c
|
UTSW |
18 |
60,379,355 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7443:Iigp1c
|
UTSW |
18 |
60,379,122 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9261:Iigp1c
|
UTSW |
18 |
60,353,820 (GRCm39) |
intron |
probably benign |
|
|
R9650:Iigp1c
|
UTSW |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Iigp1c
|
UTSW |
18 |
60,379,368 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Posted On |
2015-04-16 |
Incidental Mutation