Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02277:Myo1f'

287386

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myo1f

Ensembl Gene

ENSMUSG00000024300

Gene Name

myosin IF

Synonyms

C330006B10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.143) question?

Stock #

IGL02277

Quality Score

Status

Chromosome

Chromosomal Location

33774681-33826738 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 33798835 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000084887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372] [ENSMUST00000174695]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000087605

SMART Domains

Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300

Domain	Start	End	E-Value	Type
MYSc	11	691	N/A	SMART
IQ	692	714	7.57e0	SMART
Pfam:Myosin_TH1	717	909	1.7e-51	PFAM
low complexity region	939	952	N/A	INTRINSIC
low complexity region	973	987	N/A	INTRINSIC
low complexity region	991	1001	N/A	INTRINSIC
SH3	1044	1098	2.09e-19	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173372

SMART Domains

Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300

Domain	Start	End	E-Value	Type
MYSc	11	691	N/A	SMART
IQ	692	714	7.57e0	SMART
Pfam:Myosin_TH1	716	780	6e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173426

Predicted Effect

probably benign
Transcript: ENSMUST00000174695

SMART Domains

Protein: ENSMUSP00000134600
Gene: ENSMUSG00000024300

Domain	Start	End	E-Value	Type
Pfam:Myosin_head	47	98	1.3e-21	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	C	T	9: 57,165,708 (GRCm39)	G222D	probably benign	Het
Abcc6	T	C	7: 45,650,485 (GRCm39)	D625G	probably benign	Het
Akr1c12	C	T	13: 4,322,268 (GRCm39)	R258Q	probably damaging	Het
Akr1c20	T	A	13: 4,564,404 (GRCm39)	E36D	probably benign	Het
Csn2	A	G	5: 87,845,881 (GRCm39)		probably benign	Het
Dennd5a	T	C	7: 109,497,176 (GRCm39)	I1084V	possibly damaging	Het
Dlg1	A	G	16: 31,609,082 (GRCm39)	I259V	probably damaging	Het
Dpysl5	A	G	5: 30,946,125 (GRCm39)	I344V	probably damaging	Het
Fcrl6	A	G	1: 172,426,686 (GRCm39)	C87R	probably damaging	Het
Fras1	A	G	5: 96,735,977 (GRCm39)	E524G	probably benign	Het
Gabpb2	A	G	3: 95,096,595 (GRCm39)	V270A	probably benign	Het
Gm5591	T	A	7: 38,218,462 (GRCm39)	I804F	possibly damaging	Het
Gm5591	T	C	7: 38,219,856 (GRCm39)	D339G	probably damaging	Het
Ighv2-5	T	A	12: 113,649,127 (GRCm39)	T109S	possibly damaging	Het
Ints4	T	A	7: 97,136,665 (GRCm39)	L119Q	probably damaging	Het
Kansl3	A	T	1: 36,388,028 (GRCm39)	D386E	possibly damaging	Het
Kdm3b	A	T	18: 34,956,717 (GRCm39)	H1224L	probably damaging	Het
Macf1	C	A	4: 123,380,497 (GRCm39)	R1523L	probably damaging	Het
Nup188	A	G	2: 30,216,523 (GRCm39)	T776A	possibly damaging	Het
Or1q1	G	A	2: 36,887,196 (GRCm39)		probably null	Het
Or2y8	T	A	11: 52,036,189 (GRCm39)	H56L	probably damaging	Het
Or4f56	T	A	2: 111,703,925 (GRCm39)	I92F	possibly damaging	Het
Plxnb1	T	A	9: 108,941,201 (GRCm39)	L1660Q	probably damaging	Het
Ppp1r17	A	G	6: 56,003,123 (GRCm39)	D71G	probably damaging	Het
Ptprt	T	C	2: 161,389,301 (GRCm39)	Q1264R	probably damaging	Het
Rgl3	C	T	9: 21,885,405 (GRCm39)	V642M	probably damaging	Het
Slc26a2	T	C	18: 61,332,052 (GRCm39)	T460A	probably damaging	Het
Smtnl2	T	A	11: 72,282,199 (GRCm39)	M395L	probably damaging	Het
St3gal5	A	T	6: 72,119,184 (GRCm39)	T99S	possibly damaging	Het
Unc5b	T	C	10: 60,610,521 (GRCm39)	N421S	probably benign	Het
Zcchc17	G	A	4: 130,221,014 (GRCm39)	T179M	probably benign	Het
Zfp369	T	C	13: 65,432,746 (GRCm39)	S79P	probably damaging	Het

Other mutations in Myo1f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00851:Myo1f	APN	17	33,800,938 (GRCm39)	missense	probably benign	0.01
IGL01019:Myo1f	APN	17	33,811,977 (GRCm39)	missense	possibly damaging	0.93
IGL01524:Myo1f	APN	17	33,798,857 (GRCm39)	missense	probably damaging	1.00
IGL01744:Myo1f	APN	17	33,802,654 (GRCm39)	splice site	probably benign
IGL01951:Myo1f	APN	17	33,816,991 (GRCm39)	missense	possibly damaging	0.64
IGL02132:Myo1f	APN	17	33,798,945 (GRCm39)	missense	probably benign	0.10
IGL02170:Myo1f	APN	17	33,797,246 (GRCm39)	missense	probably benign	0.14
IGL02173:Myo1f	APN	17	33,826,318 (GRCm39)	missense	probably damaging	1.00
IGL02550:Myo1f	APN	17	33,799,124 (GRCm39)	unclassified	probably benign
IGL02550:Myo1f	APN	17	33,807,116 (GRCm39)	missense	probably damaging	1.00
IGL02615:Myo1f	APN	17	33,823,630 (GRCm39)	missense	probably benign
IGL02801:Myo1f	APN	17	33,797,111 (GRCm39)	missense	probably damaging	1.00
IGL02817:Myo1f	APN	17	33,823,532 (GRCm39)	missense	probably benign	0.06
IGL02904:Myo1f	APN	17	33,804,632 (GRCm39)	nonsense	probably null
IGL03056:Myo1f	APN	17	33,804,574 (GRCm39)	missense	probably damaging	1.00
IGL03334:Myo1f	APN	17	33,817,168 (GRCm39)	missense	probably damaging	1.00
R0066:Myo1f	UTSW	17	33,820,677 (GRCm39)	missense	probably damaging	0.98
R0066:Myo1f	UTSW	17	33,820,677 (GRCm39)	missense	probably damaging	0.98
R0321:Myo1f	UTSW	17	33,811,986 (GRCm39)	missense	probably benign	0.31
R0375:Myo1f	UTSW	17	33,820,930 (GRCm39)	missense	probably benign	0.27
R0487:Myo1f	UTSW	17	33,797,258 (GRCm39)	missense	probably damaging	1.00
R0925:Myo1f	UTSW	17	33,797,107 (GRCm39)	missense	probably damaging	0.96
R1394:Myo1f	UTSW	17	33,802,714 (GRCm39)	missense	probably damaging	0.96
R1395:Myo1f	UTSW	17	33,802,714 (GRCm39)	missense	probably damaging	0.96
R1474:Myo1f	UTSW	17	33,813,001 (GRCm39)	missense	possibly damaging	0.77
R1760:Myo1f	UTSW	17	33,805,172 (GRCm39)	missense	probably benign	0.03
R1965:Myo1f	UTSW	17	33,817,146 (GRCm39)	nonsense	probably null
R2409:Myo1f	UTSW	17	33,795,641 (GRCm39)	missense	probably damaging	1.00
R2432:Myo1f	UTSW	17	33,794,823 (GRCm39)	missense	probably damaging	1.00
R4610:Myo1f	UTSW	17	33,801,306 (GRCm39)	missense	probably damaging	1.00
R4785:Myo1f	UTSW	17	33,817,165 (GRCm39)	missense	possibly damaging	0.95
R5239:Myo1f	UTSW	17	33,820,709 (GRCm39)	missense	probably benign	0.00
R5881:Myo1f	UTSW	17	33,799,259 (GRCm39)	missense	possibly damaging	0.46
R5881:Myo1f	UTSW	17	33,795,627 (GRCm39)	missense	probably damaging	1.00
R6160:Myo1f	UTSW	17	33,823,318 (GRCm39)	missense	probably benign
R6210:Myo1f	UTSW	17	33,820,044 (GRCm39)	missense	probably damaging	1.00
R6365:Myo1f	UTSW	17	33,805,090 (GRCm39)	missense	probably benign
R6464:Myo1f	UTSW	17	33,795,621 (GRCm39)	missense	probably damaging	1.00
R6532:Myo1f	UTSW	17	33,794,820 (GRCm39)	missense	probably damaging	1.00
R6678:Myo1f	UTSW	17	33,794,819 (GRCm39)	missense	probably damaging	1.00
R7241:Myo1f	UTSW	17	33,798,902 (GRCm39)	missense	probably damaging	0.99
R7266:Myo1f	UTSW	17	33,820,668 (GRCm39)	missense	probably benign
R7513:Myo1f	UTSW	17	33,794,788 (GRCm39)	missense	probably damaging	1.00
R7606:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R7779:Myo1f	UTSW	17	33,797,247 (GRCm39)	missense	probably benign	0.27
R7853:Myo1f	UTSW	17	33,795,672 (GRCm39)	missense	probably damaging	1.00
R7884:Myo1f	UTSW	17	33,817,270 (GRCm39)	missense	probably damaging	1.00
R8507:Myo1f	UTSW	17	33,816,992 (GRCm39)	missense	probably benign	0.09
R8807:Myo1f	UTSW	17	33,794,879 (GRCm39)	missense	probably damaging	1.00
R9009:Myo1f	UTSW	17	33,823,662 (GRCm39)	missense	probably benign	0.12
R9083:Myo1f	UTSW	17	33,813,036 (GRCm39)	missense	probably damaging	0.99
R9227:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R9230:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R9528:Myo1f	UTSW	17	33,797,156 (GRCm39)	critical splice donor site	probably null
X0028:Myo1f	UTSW	17	33,795,412 (GRCm39)	missense	possibly damaging	0.67
X0065:Myo1f	UTSW	17	33,820,957 (GRCm39)	missense	probably benign

Posted On

2015-04-16