Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02302:Zfp213'

287404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp213

Ensembl Gene

ENSMUSG00000071256

Gene Name

zinc finger protein 213

Synonyms

D17Ertd197e

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02302

Quality Score

Status

Chromosome

Chromosomal Location

23775741-23783200 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23776945 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 366 (S366P)

Ref Sequence

ENSEMBL: ENSMUSP00000093266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088673] [ENSMUST00000095606] [ENSMUST00000182769]

AlphaFold

E9QAW0

Predicted Effect

probably benign
Transcript: ENSMUST00000088673

SMART Domains

Protein: ENSMUSP00000086048
Gene: ENSMUSG00000067882

Domain	Start	End	E-Value	Type
Pfam:Peptidase_C14	3	162	4.5e-9	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000095606
AA Change: S366P

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000093266
Gene: ENSMUSG00000071256
AA Change: S366P

Domain	Start	End	E-Value	Type
SCAN	41	145	3.11e-56	SMART
KRAB	213	278	3.21e-4	SMART
ZnF_C2H2	326	348	3.89e-3	SMART
ZnF_C2H2	354	376	9.88e-5	SMART
ZnF_C2H2	382	404	6.42e-4	SMART
ZnF_C2H2	410	432	1.95e-3	SMART
ZnF_C2H2	438	460	4.4e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180920

Predicted Effect

probably benign
Transcript: ENSMUST00000182769

SMART Domains

Protein: ENSMUSP00000138283
Gene: ENSMUSG00000067882

Domain	Start	End	E-Value	Type
Pfam:Peptidase_C14	18	175	1.7e-7	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700066M21Rik	A	T	1: 57,422,257 (GRCm39)	Q211L	possibly damaging	Het
Abca14	T	A	7: 119,917,968 (GRCm39)		probably benign	Het
Abcb10	A	T	8: 124,685,411 (GRCm39)	V543D	possibly damaging	Het
Ankrd17	G	A	5: 90,431,057 (GRCm39)	T909I	probably benign	Het
Arhgef3	A	G	14: 27,084,799 (GRCm39)	N76S	probably benign	Het
Bbx	A	T	16: 50,045,278 (GRCm39)	C320S	probably damaging	Het
Castor2	G	A	5: 134,164,482 (GRCm39)	V148I	possibly damaging	Het
Cdh23	C	A	10: 60,159,302 (GRCm39)	V2159F	possibly damaging	Het
Cmtr2	G	A	8: 110,948,136 (GRCm39)	A149T	probably damaging	Het
Cntnap4	A	G	8: 113,512,535 (GRCm39)		probably benign	Het
Col6a3	A	T	1: 90,709,482 (GRCm39)	F1905I	unknown	Het
Ddx60	A	G	8: 62,428,866 (GRCm39)	Y792C	possibly damaging	Het
Dennd2b	A	G	7: 109,124,538 (GRCm39)	V1101A	probably damaging	Het
Dock4	T	C	12: 40,775,776 (GRCm39)	L573P	probably damaging	Het
Dop1b	A	G	16: 93,607,005 (GRCm39)	I2103V	probably benign	Het
Ear1	T	G	14: 44,056,504 (GRCm39)	Q121H	probably benign	Het
Eprs1	T	A	1: 185,119,321 (GRCm39)		probably benign	Het
Ero1a	T	C	14: 45,530,619 (GRCm39)	K271R	probably benign	Het
Esyt1	A	G	10: 128,348,236 (GRCm39)	L884P	probably damaging	Het
F2r	T	C	13: 95,741,160 (GRCm39)	N125S	probably damaging	Het
Fam217a	T	C	13: 35,095,144 (GRCm39)	E357G	probably damaging	Het
Gabbr1	C	T	17: 37,365,689 (GRCm39)	R123W	probably damaging	Het
Gimap4	T	G	6: 48,667,347 (GRCm39)	V34G	probably damaging	Het
Gm3248	A	T	14: 5,943,011 (GRCm38)	V180E	probably benign	Het
Hecw2	A	T	1: 53,972,407 (GRCm39)	N204K	probably damaging	Het
Ighv1-84	T	A	12: 115,944,549 (GRCm39)	K42*	probably null	Het
Kcnh7	T	A	2: 62,536,402 (GRCm39)	Q1060L	probably damaging	Het
Kif3b	T	A	2: 153,158,868 (GRCm39)	I223N	probably damaging	Het
Lama2	G	A	10: 27,088,039 (GRCm39)	P913S	probably benign	Het
Lgr4	A	G	2: 109,832,841 (GRCm39)	I334M	probably damaging	Het
Lrrc45	G	T	11: 120,609,351 (GRCm39)	E403D	possibly damaging	Het
Mccc2	A	G	13: 100,090,747 (GRCm39)	L462P	probably damaging	Het
Mfsd13b	T	C	7: 120,598,132 (GRCm39)	V346A	probably damaging	Het
Muc6	T	C	7: 141,227,763 (GRCm39)	T1342A	possibly damaging	Het
Mxd3	T	C	13: 55,477,091 (GRCm39)	N56S	probably benign	Het
Niban2	A	G	2: 32,811,135 (GRCm39)	I382V	probably benign	Het
Ntn5	G	T	7: 45,343,672 (GRCm39)	R337L	probably damaging	Het
Nynrin	A	G	14: 56,105,962 (GRCm39)	K894E	probably benign	Het
Or1j4	G	T	2: 36,740,715 (GRCm39)	G219V	probably benign	Het
Or2a25	T	A	6: 42,889,272 (GRCm39)	Y272N	probably damaging	Het
Or4f56	A	C	2: 111,703,887 (GRCm39)	S104R	possibly damaging	Het
Or7e168	A	T	9: 19,719,981 (GRCm39)	R122S	probably damaging	Het
Pappa2	T	C	1: 158,542,571 (GRCm39)	D1772G	probably benign	Het
Pcdh18	G	T	3: 49,710,387 (GRCm39)	F309L	probably benign	Het
Pcdhac2	G	T	18: 37,279,006 (GRCm39)	R662L	probably damaging	Het
Ppp5c	G	A	7: 16,742,555 (GRCm39)	S261L	possibly damaging	Het
Qng1	G	A	13: 58,529,749 (GRCm39)	R288W	probably damaging	Het
Rc3h1	T	C	1: 160,765,675 (GRCm39)		probably benign	Het
Rfx8	A	C	1: 39,704,682 (GRCm39)	S578A	possibly damaging	Het
Rhbdl3	T	G	11: 80,244,507 (GRCm39)	*405E	probably null	Het
Rita1	C	T	5: 120,747,858 (GRCm39)	A147T	probably damaging	Het
Rnf139	G	T	15: 58,770,606 (GRCm39)	L210F	probably damaging	Het
Rragc	A	G	4: 123,814,879 (GRCm39)	R192G	possibly damaging	Het
Ryr3	A	T	2: 112,794,701 (GRCm39)	V137E	probably damaging	Het
S100pbp	A	T	4: 129,076,234 (GRCm39)	D30E	probably damaging	Het
Smchd1	A	T	17: 71,665,128 (GRCm39)		probably benign	Het
Sppl3	T	A	5: 115,220,390 (GRCm39)	C101S	probably benign	Het
St8sia6	T	C	2: 13,728,324 (GRCm39)	T74A	probably benign	Het
Sult3a1	A	G	10: 33,742,571 (GRCm39)	N66S	possibly damaging	Het
Sv2b	T	A	7: 74,773,947 (GRCm39)	K508M	probably damaging	Het
Terf1	T	C	1: 15,903,626 (GRCm39)	S275P	probably damaging	Het
Tmed8	G	T	12: 87,220,990 (GRCm39)	H199N	probably damaging	Het
Tubg2	A	T	11: 101,046,971 (GRCm39)	Q9L	probably damaging	Het
Ubxn4	C	T	1: 128,183,848 (GRCm39)		probably benign	Het
Usp34	C	T	11: 23,417,243 (GRCm39)	T2964I	possibly damaging	Het

Other mutations in Zfp213

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01301:Zfp213	APN	17	23,780,391 (GRCm39)	missense	probably benign	0.18
ANU18:Zfp213	UTSW	17	23,780,391 (GRCm39)	missense	probably benign	0.18
R2137:Zfp213	UTSW	17	23,778,481 (GRCm39)	splice site	probably null
R4010:Zfp213	UTSW	17	23,777,064 (GRCm39)	missense	possibly damaging	0.93
R5149:Zfp213	UTSW	17	23,780,373 (GRCm39)	missense	probably damaging	0.97
R5595:Zfp213	UTSW	17	23,780,160 (GRCm39)	missense	possibly damaging	0.92
R5979:Zfp213	UTSW	17	23,776,885 (GRCm39)	nonsense	probably null
R6227:Zfp213	UTSW	17	23,776,996 (GRCm39)	missense	probably benign	0.16
R6711:Zfp213	UTSW	17	23,778,485 (GRCm39)	missense	probably benign
R7105:Zfp213	UTSW	17	23,777,178 (GRCm39)	missense	probably benign	0.40
R7409:Zfp213	UTSW	17	23,778,603 (GRCm39)	splice site	probably null

Posted On

2015-04-16