Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02305:Apol10b'

287539

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Apol10b

Ensembl Gene

ENSMUSG00000050014

Gene Name

apolipoprotein L 10B

Synonyms

9130218O11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02305

Quality Score

Status

Chromosome

Chromosomal Location

77468019-77480325 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 77469630 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 182 (R182S)

Ref Sequence

ENSEMBL: ENSMUSP00000086890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089465]

AlphaFold

G3X9K7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000089465
AA Change: R182S

PolyPhen 2 Score 0.551 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000086890
Gene: ENSMUSG00000050014
AA Change: R182S

Domain	Start	End	E-Value	Type
Pfam:ApoL	28	328	2.8e-88	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts16	G	A	13: 70,921,048 (GRCm39)	T599I	probably damaging	Het
Ahi1	A	G	10: 20,846,796 (GRCm39)	T409A	probably benign	Het
Arhgap35	A	G	7: 16,297,590 (GRCm39)	F492L	probably benign	Het
Ccdc136	A	G	6: 29,406,173 (GRCm39)	D173G	probably damaging	Het
Ccndbp1	T	C	2: 120,841,933 (GRCm39)	L67P	probably damaging	Het
Dync2h1	C	T	9: 7,122,678 (GRCm39)	V2093I	probably benign	Het
Eps15l1	T	C	8: 73,140,853 (GRCm39)	K213R	probably null	Het
Fat4	A	T	3: 39,064,137 (GRCm39)	N4698Y	probably damaging	Het
Frmpd1	G	T	4: 45,249,209 (GRCm39)	R133L	probably damaging	Het
Gdi2	T	A	13: 3,606,428 (GRCm39)	M158K	probably damaging	Het
Hoxc8	A	G	15: 102,901,025 (GRCm39)	Y156C	probably damaging	Het
Iho1	A	T	9: 108,283,031 (GRCm39)	M219K	possibly damaging	Het
Kcnh2	T	C	5: 24,527,658 (GRCm39)	D898G	possibly damaging	Het
Kng2	T	C	16: 22,819,374 (GRCm39)		probably benign	Het
Men1	T	C	19: 6,390,168 (GRCm39)	L566P	probably damaging	Het
Mtmr2	T	C	9: 13,706,551 (GRCm39)	W153R	probably damaging	Het
Mug2	T	G	6: 122,013,015 (GRCm39)	L309R	probably benign	Het
Myo7a	A	G	7: 97,700,836 (GRCm39)	*2165R	probably null	Het
Ogfod2	T	C	5: 124,250,910 (GRCm39)		probably null	Het
Or8b48	C	T	9: 38,492,809 (GRCm39)	P79S	probably damaging	Het
Or8g20	A	T	9: 39,396,333 (GRCm39)	I72N	probably damaging	Het
Pard6g	T	C	18: 80,160,985 (GRCm39)	L366P	probably damaging	Het
Pdlim4	A	T	11: 53,946,759 (GRCm39)	L117H	probably damaging	Het
Pkd1l1	G	A	11: 8,852,467 (GRCm39)	A672V	probably benign	Het
Pomt2	A	G	12: 87,164,703 (GRCm39)		probably benign	Het
Prpf4	T	A	4: 62,333,633 (GRCm39)		probably benign	Het
Rad17	C	T	13: 100,770,370 (GRCm39)		probably null	Het
Ryr3	T	A	2: 112,475,622 (GRCm39)	I4499F	probably damaging	Het
Sav1	A	G	12: 70,033,550 (GRCm39)		probably benign	Het
Scube1	A	T	15: 83,491,591 (GRCm39)	F887I	probably damaging	Het
Slc5a6	T	C	5: 31,195,179 (GRCm39)	S473G	probably benign	Het
Taf1b	T	C	12: 24,594,270 (GRCm39)	S268P	possibly damaging	Het
Tmem135	A	T	7: 88,814,331 (GRCm39)		probably null	Het
Vmn2r104	A	T	17: 20,263,118 (GRCm39)	N114K	probably benign	Het
Ypel5	A	T	17: 73,155,591 (GRCm39)	Y53F	probably benign	Het
Zfp438	A	G	18: 5,213,674 (GRCm39)	V428A	possibly damaging	Het
Zzef1	T	C	11: 72,757,423 (GRCm39)		probably benign	Het

Other mutations in Apol10b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01295:Apol10b	APN	15	77,469,796 (GRCm39)	missense	probably damaging	1.00
IGL01654:Apol10b	APN	15	77,472,996 (GRCm39)	missense	probably benign
IGL01905:Apol10b	APN	15	77,469,559 (GRCm39)	missense	possibly damaging	0.92
IGL01969:Apol10b	APN	15	77,472,885 (GRCm39)	splice site	probably null
R0361:Apol10b	UTSW	15	77,469,586 (GRCm39)	missense	possibly damaging	0.82
R0395:Apol10b	UTSW	15	77,469,840 (GRCm39)	missense	probably damaging	1.00
R0437:Apol10b	UTSW	15	77,469,608 (GRCm39)	missense	probably benign	0.00
R0502:Apol10b	UTSW	15	77,476,349 (GRCm39)	splice site	probably benign
R0688:Apol10b	UTSW	15	77,469,419 (GRCm39)	missense	probably damaging	0.99
R1663:Apol10b	UTSW	15	77,472,914 (GRCm39)	missense	probably damaging	1.00
R1763:Apol10b	UTSW	15	77,469,215 (GRCm39)	missense	probably benign	0.14
R4884:Apol10b	UTSW	15	77,473,006 (GRCm39)	missense	possibly damaging	0.93
R6177:Apol10b	UTSW	15	77,469,987 (GRCm39)	missense	possibly damaging	0.50
R7062:Apol10b	UTSW	15	77,469,473 (GRCm39)	missense	probably benign	0.00
R7480:Apol10b	UTSW	15	77,472,988 (GRCm39)	missense	probably benign	0.02
R8511:Apol10b	UTSW	15	77,469,211 (GRCm39)	missense	probably benign	0.43
R8511:Apol10b	UTSW	15	77,469,210 (GRCm39)	missense	probably benign	0.03
R8703:Apol10b	UTSW	15	77,472,897 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16