Incidental Mutation 'IGL02307:Or4n4b'
ID 287650
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4n4b
Ensembl Gene ENSMUSG00000090874
Gene Name olfactory receptor family 4 subfamily N member 4B
Synonyms Olfr733, GA_x6K02T2PMLR-5992342-5991416, MOR241-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02307
Quality Score
Status
Chromosome 14
Chromosomal Location 50535794-50536787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 50536295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 157 (I157S)
Ref Sequence ENSEMBL: ENSMUSP00000149807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163469] [ENSMUST00000214372] [ENSMUST00000214756] [ENSMUST00000216195]
AlphaFold Q14AK5
Predicted Effect probably damaging
Transcript: ENSMUST00000163469
AA Change: I157S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128332
Gene: ENSMUSG00000090874
AA Change: I157S

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 6.4e-41 PFAM
Pfam:7tm_1 41 288 1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214372
AA Change: I157S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214756
AA Change: I157S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216195
AA Change: I157S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,935,395 (GRCm39) D323G probably damaging Het
Ankrd28 A G 14: 31,455,665 (GRCm39) C417R probably damaging Het
Astn1 C T 1: 158,502,184 (GRCm39) R1133C probably damaging Het
Bdp1 C A 13: 100,229,946 (GRCm39) G256V probably damaging Het
Cald1 A G 6: 34,730,390 (GRCm39) K252E probably damaging Het
Ccdc141 T C 2: 76,859,686 (GRCm39) E985G probably damaging Het
Cdc23 A G 18: 34,774,442 (GRCm39) I279T possibly damaging Het
Col16a1 C T 4: 129,952,802 (GRCm39) P416L probably damaging Het
Coro1a T C 7: 126,300,736 (GRCm39) D197G probably damaging Het
Ctnnd2 C T 15: 30,647,357 (GRCm39) T351I possibly damaging Het
Fam76b A G 9: 13,755,332 (GRCm39) N313S probably damaging Het
Fbxw20 C A 9: 109,062,601 (GRCm39) W75L possibly damaging Het
Gjd2 T C 2: 113,842,394 (GRCm39) T28A possibly damaging Het
Glyctk A C 9: 106,032,963 (GRCm39) L350R possibly damaging Het
Gm20726 A T 14: 54,870,060 (GRCm39) V237D probably damaging Het
Gm57858 T C 3: 36,073,016 (GRCm39) K422R possibly damaging Het
Gpr22 C A 12: 31,758,739 (GRCm39) C461F possibly damaging Het
Grhl2 A G 15: 37,288,532 (GRCm39) T279A probably damaging Het
Gstm3 G A 3: 107,874,929 (GRCm39) R108C probably damaging Het
Haus6 T C 4: 86,502,072 (GRCm39) T600A possibly damaging Het
Htra4 G A 8: 25,523,710 (GRCm39) A285V probably damaging Het
Igkv14-100 C T 6: 68,496,349 (GRCm39) P81S probably damaging Het
Kif24 T G 4: 41,395,274 (GRCm39) Q533P probably benign Het
Klhl1 A T 14: 96,438,809 (GRCm39) N496K possibly damaging Het
Lama3 G T 18: 12,714,840 (GRCm39) R1667L probably benign Het
Lct T A 1: 128,214,327 (GRCm39) H1815L possibly damaging Het
Mrgprb2 T A 7: 48,202,644 (GRCm39) Y27F probably benign Het
Mrpl15 A T 1: 4,854,176 (GRCm39) H86Q possibly damaging Het
Myo10 C T 15: 25,776,401 (GRCm39) probably benign Het
Nrp1 T C 8: 129,229,201 (GRCm39) L893P probably damaging Het
Or51a8 A T 7: 102,550,086 (GRCm39) N171Y probably benign Het
Ovol1 T A 19: 5,603,643 (GRCm39) D86V possibly damaging Het
Pacs2 T A 12: 113,034,393 (GRCm39) M851K probably damaging Het
Pde1a A T 2: 79,736,412 (GRCm39) M39K possibly damaging Het
Pdpn T C 4: 143,000,550 (GRCm39) H94R possibly damaging Het
Plcg2 T A 8: 118,306,635 (GRCm39) probably null Het
Pzp A T 6: 128,466,049 (GRCm39) Y1210* probably null Het
Rnf148 G T 6: 23,654,890 (GRCm39) S35R probably benign Het
Ros1 A T 10: 52,004,534 (GRCm39) S1008T possibly damaging Het
Rps18-ps6 G T 13: 97,896,871 (GRCm39) Q76K probably benign Het
Sis A T 3: 72,819,167 (GRCm39) probably benign Het
Spag9 T A 11: 93,992,986 (GRCm39) probably null Het
Srbd1 A G 17: 86,433,616 (GRCm39) L327P probably damaging Het
Steap3 A T 1: 120,169,390 (GRCm39) Y264* probably null Het
Swap70 A G 7: 109,880,501 (GRCm39) E572G probably benign Het
Traf7 C A 17: 24,732,020 (GRCm39) C193F possibly damaging Het
Trmt11 T C 10: 30,470,150 (GRCm39) D58G possibly damaging Het
Tsc22d1 T C 14: 76,653,901 (GRCm39) S127P probably damaging Het
Usf1 T A 1: 171,243,314 (GRCm39) S30R probably damaging Het
Ush1c A G 7: 45,846,612 (GRCm39) probably benign Het
Utrn A T 10: 12,625,809 (GRCm39) L124* probably null Het
Vmn2r75 T C 7: 85,814,974 (GRCm39) N173S probably benign Het
Zic2 T C 14: 122,714,046 (GRCm39) V320A possibly damaging Het
Other mutations in Or4n4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or4n4b APN 14 50,535,969 (GRCm39) missense probably benign 0.00
IGL02247:Or4n4b APN 14 50,536,571 (GRCm39) missense probably damaging 1.00
IGL02492:Or4n4b APN 14 50,536,060 (GRCm39) missense probably damaging 1.00
PIT4378001:Or4n4b UTSW 14 50,536,355 (GRCm39) missense probably benign
R0544:Or4n4b UTSW 14 50,536,139 (GRCm39) missense probably benign 0.20
R1603:Or4n4b UTSW 14 50,536,491 (GRCm39) missense possibly damaging 0.95
R1881:Or4n4b UTSW 14 50,536,472 (GRCm39) missense probably damaging 1.00
R3731:Or4n4b UTSW 14 50,535,962 (GRCm39) missense probably damaging 1.00
R4271:Or4n4b UTSW 14 50,535,908 (GRCm39) missense probably damaging 1.00
R4512:Or4n4b UTSW 14 50,536,453 (GRCm39) missense probably damaging 1.00
R5601:Or4n4b UTSW 14 50,536,318 (GRCm39) missense probably damaging 1.00
R6468:Or4n4b UTSW 14 50,535,924 (GRCm39) missense probably benign 0.02
R6614:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign 0.00
R7013:Or4n4b UTSW 14 50,536,656 (GRCm39) missense probably damaging 0.99
R7083:Or4n4b UTSW 14 50,536,736 (GRCm39) missense possibly damaging 0.81
R7274:Or4n4b UTSW 14 50,535,879 (GRCm39) missense probably benign 0.01
R7493:Or4n4b UTSW 14 50,536,281 (GRCm39) missense probably benign 0.02
R7653:Or4n4b UTSW 14 50,536,604 (GRCm39) missense possibly damaging 0.82
R7659:Or4n4b UTSW 14 50,536,698 (GRCm39) missense probably benign 0.00
R7885:Or4n4b UTSW 14 50,536,041 (GRCm39) missense probably damaging 1.00
R9138:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign
R9497:Or4n4b UTSW 14 50,536,362 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16