Incidental Mutation 'IGL02310:Olfr1410'
ID287766
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1410
Ensembl Gene ENSMUSG00000063583
Gene Nameolfactory receptor 1410
SynonymsMOR208-2, GA_x6K02T2R7CC-81146179-81145211
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL02310
Quality Score
Status
Chromosome1
Chromosomal Location92605782-92614806 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 92608065 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 76 (V76A)
Ref Sequence ENSEMBL: ENSMUSP00000149621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000079790] [ENSMUST00000216553] [ENSMUST00000217316]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073748
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: V76A

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000079790
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000078720
Gene: ENSMUSG00000063583
AA Change: V76A

DomainStartEndE-ValueType
Pfam:7tm_4 38 314 2.6e-50 PFAM
Pfam:7tm_1 48 302 9.2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216553
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217316
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik A G 9: 22,424,428 Y114C probably benign Het
Ano4 T A 10: 89,023,878 K382* probably null Het
Bcl9l A G 9: 44,509,305 Y1299C probably damaging Het
Best1 T A 19: 9,989,152 H357L probably benign Het
Cdc26 T C 4: 62,395,029 probably benign Het
Esyt2 C T 12: 116,365,921 L700F probably benign Het
Fkbp15 T C 4: 62,340,316 Y138C probably damaging Het
Gbp6 T C 5: 105,290,975 N16D probably benign Het
Gm44805 A G 7: 19,671,763 *98Q probably null Het
Hecw2 T C 1: 53,923,916 D812G probably null Het
Hic2 G A 16: 17,257,757 R150Q probably damaging Het
Kif21b T A 1: 136,159,757 L937Q probably damaging Het
Klhl36 T A 8: 119,869,617 probably null Het
Mug2 C T 6: 122,059,123 probably benign Het
Pdcl2 A T 5: 76,317,881 I116N probably damaging Het
Pkn2 A G 3: 142,811,580 I482T probably damaging Het
Prss53 T G 7: 127,886,614 D518A probably benign Het
Psme4 A G 11: 30,837,484 D1093G probably benign Het
Tmcc2 A T 1: 132,358,907 I602N probably damaging Het
Tmem55b T C 14: 50,929,210 T187A possibly damaging Het
Ttn C T 2: 76,788,691 V16115I possibly damaging Het
Zbtb21 G T 16: 97,951,790 T459K possibly damaging Het
Other mutations in Olfr1410
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0189:Olfr1410 UTSW 1 92607893 missense probably damaging 0.99
R0520:Olfr1410 UTSW 1 92608749 missense probably damaging 1.00
R0605:Olfr1410 UTSW 1 92607896 missense probably benign 0.02
R1568:Olfr1410 UTSW 1 92607954 missense probably damaging 1.00
R1753:Olfr1410 UTSW 1 92608400 missense probably benign 0.07
R1778:Olfr1410 UTSW 1 92608109 missense possibly damaging 0.88
R2960:Olfr1410 UTSW 1 92608328 missense probably benign 0.00
R4206:Olfr1410 UTSW 1 92608595 missense possibly damaging 0.95
R7379:Olfr1410 UTSW 1 92608467 missense possibly damaging 0.76
R7868:Olfr1410 UTSW 1 92608515 missense possibly damaging 0.63
R7951:Olfr1410 UTSW 1 92608515 missense possibly damaging 0.63
Z1176:Olfr1410 UTSW 1 92607751 start gained probably benign
Posted On2015-04-16