Incidental Mutation 'IGL02310:Or9s14'
ID 287766
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or9s14
Ensembl Gene ENSMUSG00000063583
Gene Name olfactory receptor family 9 subfamily S member 14
Synonyms Olfr1410, MOR208-2, GA_x6K02T2R7CC-81146179-81145211
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02310
Quality Score
Status
Chromosome 1
Chromosomal Location 92535561-92536529 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92535787 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 76 (V76A)
Ref Sequence ENSEMBL: ENSMUSP00000149621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000079790] [ENSMUST00000216553] [ENSMUST00000217316]
AlphaFold E9PYK6
Predicted Effect possibly damaging
Transcript: ENSMUST00000073748
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: V76A

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000079790
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000078720
Gene: ENSMUSG00000063583
AA Change: V76A

DomainStartEndE-ValueType
Pfam:7tm_4 38 314 2.6e-50 PFAM
Pfam:7tm_1 48 302 9.2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216553
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217316
AA Change: V76A

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 T A 10: 88,859,740 (GRCm39) K382* probably null Het
Apoc2l A G 7: 19,405,688 (GRCm39) *98Q probably null Het
Bcl9l A G 9: 44,420,602 (GRCm39) Y1299C probably damaging Het
Best1 T A 19: 9,966,516 (GRCm39) H357L probably benign Het
Cdc26 T C 4: 62,313,266 (GRCm39) probably benign Het
Esyt2 C T 12: 116,329,541 (GRCm39) L700F probably benign Het
Fkbp15 T C 4: 62,258,553 (GRCm39) Y138C probably damaging Het
Gbp6 T C 5: 105,438,841 (GRCm39) N16D probably benign Het
Hecw2 T C 1: 53,963,075 (GRCm39) D812G probably null Het
Hic2 G A 16: 17,075,621 (GRCm39) R150Q probably damaging Het
Kif21b T A 1: 136,087,495 (GRCm39) L937Q probably damaging Het
Klhl36 T A 8: 120,596,356 (GRCm39) probably null Het
Matcap2 A G 9: 22,335,724 (GRCm39) Y114C probably benign Het
Mug2 C T 6: 122,036,082 (GRCm39) probably benign Het
Pdcl2 A T 5: 76,465,728 (GRCm39) I116N probably damaging Het
Pip4p1 T C 14: 51,166,667 (GRCm39) T187A possibly damaging Het
Pkn2 A G 3: 142,517,341 (GRCm39) I482T probably damaging Het
Prss53 T G 7: 127,485,786 (GRCm39) D518A probably benign Het
Psme4 A G 11: 30,787,484 (GRCm39) D1093G probably benign Het
Tmcc2 A T 1: 132,286,645 (GRCm39) I602N probably damaging Het
Ttn C T 2: 76,619,035 (GRCm39) V16115I possibly damaging Het
Zbtb21 G T 16: 97,752,990 (GRCm39) T459K possibly damaging Het
Other mutations in Or9s14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0189:Or9s14 UTSW 1 92,535,615 (GRCm39) missense probably damaging 0.99
R0520:Or9s14 UTSW 1 92,536,471 (GRCm39) missense probably damaging 1.00
R0605:Or9s14 UTSW 1 92,535,618 (GRCm39) missense probably benign 0.02
R1568:Or9s14 UTSW 1 92,535,676 (GRCm39) missense probably damaging 1.00
R1753:Or9s14 UTSW 1 92,536,122 (GRCm39) missense probably benign 0.07
R1778:Or9s14 UTSW 1 92,535,831 (GRCm39) missense possibly damaging 0.88
R2960:Or9s14 UTSW 1 92,536,050 (GRCm39) missense probably benign 0.00
R4206:Or9s14 UTSW 1 92,536,317 (GRCm39) missense possibly damaging 0.95
R7379:Or9s14 UTSW 1 92,536,189 (GRCm39) missense possibly damaging 0.76
R7868:Or9s14 UTSW 1 92,536,237 (GRCm39) missense possibly damaging 0.63
R8447:Or9s14 UTSW 1 92,535,494 (GRCm39) start gained probably benign
R8925:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R8927:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R9512:Or9s14 UTSW 1 92,535,990 (GRCm39) missense probably benign 0.00
Z1176:Or9s14 UTSW 1 92,535,473 (GRCm39) start gained probably benign
Posted On 2015-04-16