Incidental Mutation 'IGL02310:Cdc26'
ID287787
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc26
Ensembl Gene ENSMUSG00000066149
Gene Namecell division cycle 26
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.813) question?
Stock #IGL02310
Quality Score
Status
Chromosome4
Chromosomal Location62383654-62408642 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 62395029 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084525] [ENSMUST00000084526] [ENSMUST00000107459] [ENSMUST00000122092] [ENSMUST00000134727]
Predicted Effect probably benign
Transcript: ENSMUST00000084525
SMART Domains Protein: ENSMUSP00000081573
Gene: ENSMUSG00000066149

DomainStartEndE-ValueType
Pfam:APC_CDC26 1 66 1.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000084526
SMART Domains Protein: ENSMUSP00000081574
Gene: ENSMUSG00000066150

DomainStartEndE-ValueType
low complexity region 1 19 N/A INTRINSIC
Pfam:Ctr 49 181 2e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107459
SMART Domains Protein: ENSMUSP00000103083
Gene: ENSMUSG00000066149

DomainStartEndE-ValueType
Pfam:ANAPC_CDC26 1 80 7.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122092
SMART Domains Protein: ENSMUSP00000112822
Gene: ENSMUSG00000066150

DomainStartEndE-ValueType
low complexity region 1 19 N/A INTRINSIC
Pfam:Ctr 49 130 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134727
SMART Domains Protein: ENSMUSP00000120496
Gene: ENSMUSG00000066149

DomainStartEndE-ValueType
Pfam:APC_CDC26 1 66 1.1e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik A G 9: 22,424,428 Y114C probably benign Het
Ano4 T A 10: 89,023,878 K382* probably null Het
Bcl9l A G 9: 44,509,305 Y1299C probably damaging Het
Best1 T A 19: 9,989,152 H357L probably benign Het
Esyt2 C T 12: 116,365,921 L700F probably benign Het
Fkbp15 T C 4: 62,340,316 Y138C probably damaging Het
Gbp6 T C 5: 105,290,975 N16D probably benign Het
Gm44805 A G 7: 19,671,763 *98Q probably null Het
Hecw2 T C 1: 53,923,916 D812G probably null Het
Hic2 G A 16: 17,257,757 R150Q probably damaging Het
Kif21b T A 1: 136,159,757 L937Q probably damaging Het
Klhl36 T A 8: 119,869,617 probably null Het
Mug2 C T 6: 122,059,123 probably benign Het
Olfr1410 T C 1: 92,608,065 V76A possibly damaging Het
Pdcl2 A T 5: 76,317,881 I116N probably damaging Het
Pkn2 A G 3: 142,811,580 I482T probably damaging Het
Prss53 T G 7: 127,886,614 D518A probably benign Het
Psme4 A G 11: 30,837,484 D1093G probably benign Het
Tmcc2 A T 1: 132,358,907 I602N probably damaging Het
Tmem55b T C 14: 50,929,210 T187A possibly damaging Het
Ttn C T 2: 76,788,691 V16115I possibly damaging Het
Zbtb21 G T 16: 97,951,790 T459K possibly damaging Het
Other mutations in Cdc26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01958:Cdc26 APN 4 62402764 missense probably damaging 1.00
IGL03209:Cdc26 APN 4 62395014 missense possibly damaging 0.60
R1765:Cdc26 UTSW 4 62394918 missense probably benign 0.01
R6228:Cdc26 UTSW 4 62402794 missense probably damaging 1.00
Posted On2015-04-16