Incidental Mutation 'IGL02313:Olfr836'
ID 287868
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr836
Ensembl Gene ENSMUSG00000059303
Gene Name olfactory receptor 836
Synonyms MOR152-3, GA_x6K02T2PVTD-12857805-12858749
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.159) question?
Stock # IGL02313
Quality Score
Status
Chromosome 9
Chromosomal Location 19120382-19125938 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19121375 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 140 (N140I)
Ref Sequence ENSEMBL: ENSMUSP00000074514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074986] [ENSMUST00000212730] [ENSMUST00000215981]
AlphaFold Q8VFJ3
Predicted Effect probably damaging
Transcript: ENSMUST00000074986
AA Change: N140I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000074514
Gene: ENSMUSG00000059303
AA Change: N140I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-50 PFAM
Pfam:7TM_GPCR_Srsx 38 210 9.6e-6 PFAM
Pfam:7tm_1 44 293 2.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212730
AA Change: N137I

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000215981
AA Change: N137I

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd13c T A 3: 157,947,934 N136K probably damaging Het
Aph1b A T 9: 66,790,673 probably benign Het
Atf7ip A G 6: 136,606,720 K1250E probably damaging Het
Atp8b2 T C 3: 89,949,853 N400S probably damaging Het
Brca2 C A 5: 150,538,661 S630Y probably damaging Het
Chd6 T A 2: 160,965,675 E1873V probably damaging Het
Chrna10 T C 7: 102,112,029 probably benign Het
Col6a3 A G 1: 90,811,606 L907P probably damaging Het
Cxcr6 A G 9: 123,810,705 N264S probably damaging Het
Dgkg A G 16: 22,570,230 probably benign Het
Dpysl2 T G 14: 66,824,390 M256L probably benign Het
Dsp G T 13: 38,196,523 E1816* probably null Het
Fam129c A G 8: 71,602,860 R305G possibly damaging Het
Fam13b T C 18: 34,454,656 K530E probably damaging Het
Fam49a A G 12: 12,364,751 T248A possibly damaging Het
Fastk T C 5: 24,443,092 H242R probably damaging Het
Fbxw28 A T 9: 109,337,352 H145Q possibly damaging Het
Heatr6 T C 11: 83,778,892 L910P probably damaging Het
Hmcn2 A G 2: 31,453,605 T4642A possibly damaging Het
Hspg2 A G 4: 137,508,389 T167A probably benign Het
Igsf10 A G 3: 59,330,690 L690P probably benign Het
Klhdc10 G A 6: 30,439,866 probably null Het
Krt31 A G 11: 100,048,396 Y232H probably damaging Het
Lsm3 A G 6: 91,516,088 probably benign Het
Mfn2 T A 4: 147,885,490 I375F probably damaging Het
Mfrp A T 9: 44,102,874 I180F probably damaging Het
Msh3 T C 13: 92,349,312 E168G possibly damaging Het
Naa16 A T 14: 79,384,668 V77D probably damaging Het
Nav2 T C 7: 49,558,773 S1570P probably damaging Het
Numa1 C T 7: 102,000,232 R1057* probably null Het
Nup210l G A 3: 90,122,792 A271T probably damaging Het
Ogdh T C 11: 6,355,400 V965A probably damaging Het
Olfr63 C A 17: 33,269,665 Q314K probably benign Het
Olfr734 A T 14: 50,320,016 V273E probably damaging Het
Olfr818 A G 10: 129,945,903 L53P probably damaging Het
Olfr916 T A 9: 38,658,066 I109F probably damaging Het
Pdp2 A T 8: 104,594,899 Q460L probably benign Het
Pex5l T C 3: 32,992,992 T270A probably benign Het
Pkp4 C T 2: 59,310,254 Q435* probably null Het
Prss32 G A 17: 23,856,122 V149M probably benign Het
Riox2 C A 16: 59,489,417 P378Q probably benign Het
Rita1 C T 5: 120,609,793 A147T probably damaging Het
Rsph4a T A 10: 33,905,525 S124T possibly damaging Het
Sdccag8 G A 1: 176,824,755 R24H possibly damaging Het
Slc22a1 C A 17: 12,675,500 G54* probably null Het
Slc24a5 C T 2: 125,085,647 probably benign Het
Tex101 C T 7: 24,668,325 V201M probably damaging Het
Tmprss7 T C 16: 45,681,593 Y223C probably damaging Het
Trpc4ap T C 2: 155,650,468 E382G probably damaging Het
Uggt1 A T 1: 36,184,484 Y575N probably damaging Het
Vmn2r70 T C 7: 85,565,168 I259V probably damaging Het
Xpo1 T A 11: 23,277,065 N131K probably damaging Het
Zfp579 C T 7: 4,994,433 V160M probably benign Het
Zfp697 A G 3: 98,425,450 D64G probably benign Het
Zfp974 T C 7: 27,912,253 T16A possibly damaging Het
Other mutations in Olfr836
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00907:Olfr836 APN 9 19121232 missense possibly damaging 0.88
IGL01316:Olfr836 APN 9 19121422 missense probably benign 0.10
IGL01412:Olfr836 APN 9 19121599 missense probably benign 0.00
IGL01815:Olfr836 APN 9 19121326 missense probably damaging 1.00
IGL02003:Olfr836 APN 9 19121065 missense probably benign 0.06
IGL03185:Olfr836 APN 9 19121738 missense probably damaging 1.00
IGL03186:Olfr836 APN 9 19121904 missense probably benign 0.16
R1337:Olfr836 UTSW 9 19121803 missense probably benign
R2267:Olfr836 UTSW 9 19121441 missense probably benign 0.22
R3969:Olfr836 UTSW 9 19121660 missense probably benign 0.00
R4695:Olfr836 UTSW 9 19121010 missense probably null 0.04
R4976:Olfr836 UTSW 9 19121501 missense probably damaging 1.00
R5176:Olfr836 UTSW 9 19121360 missense probably damaging 1.00
R5379:Olfr836 UTSW 9 19121077 missense probably damaging 1.00
R5638:Olfr836 UTSW 9 19121380 missense probably benign 0.00
R6084:Olfr836 UTSW 9 19121327 missense probably damaging 1.00
R6236:Olfr836 UTSW 9 19121113 missense possibly damaging 0.92
R6329:Olfr836 UTSW 9 19120957 start codon destroyed probably benign 0.08
R7151:Olfr836 UTSW 9 19121741 missense possibly damaging 0.91
R7326:Olfr836 UTSW 9 19121669 missense probably benign 0.42
R8460:Olfr836 UTSW 9 19121692 missense probably damaging 1.00
R8767:Olfr836 UTSW 9 19121626 missense possibly damaging 0.95
R8978:Olfr836 UTSW 9 19121286 nonsense probably null
R9099:Olfr836 UTSW 9 19121594 missense probably benign 0.35
R9220:Olfr836 UTSW 9 19121897 missense possibly damaging 0.82
R9236:Olfr836 UTSW 9 19121910 makesense probably null
R9265:Olfr836 UTSW 9 19121688 nonsense probably null
R9530:Olfr836 UTSW 9 19121755 missense probably benign 0.24
R9612:Olfr836 UTSW 9 19121464 missense probably benign 0.16
Posted On 2015-04-16