Incidental Mutation 'IGL02313:Zfp974'
ID287871
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Namezinc finger protein 974
Synonyms1700049G17Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02313
Quality Score
Status
Chromosome7
Chromosomal Location27907392-27929460 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 27912253 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 16 (T16A)
Ref Sequence ENSEMBL: ENSMUSP00000096238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098639
AA Change: T16A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: T16A

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129341
AA Change: T90A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709
AA Change: T90A

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd13c T A 3: 157,947,934 N136K probably damaging Het
Aph1b A T 9: 66,790,673 probably benign Het
Atf7ip A G 6: 136,606,720 K1250E probably damaging Het
Atp8b2 T C 3: 89,949,853 N400S probably damaging Het
Brca2 C A 5: 150,538,661 S630Y probably damaging Het
Chd6 T A 2: 160,965,675 E1873V probably damaging Het
Chrna10 T C 7: 102,112,029 probably benign Het
Col6a3 A G 1: 90,811,606 L907P probably damaging Het
Cxcr6 A G 9: 123,810,705 N264S probably damaging Het
Dgkg A G 16: 22,570,230 probably benign Het
Dpysl2 T G 14: 66,824,390 M256L probably benign Het
Dsp G T 13: 38,196,523 E1816* probably null Het
Fam129c A G 8: 71,602,860 R305G possibly damaging Het
Fam13b T C 18: 34,454,656 K530E probably damaging Het
Fam49a A G 12: 12,364,751 T248A possibly damaging Het
Fastk T C 5: 24,443,092 H242R probably damaging Het
Fbxw28 A T 9: 109,337,352 H145Q possibly damaging Het
Heatr6 T C 11: 83,778,892 L910P probably damaging Het
Hmcn2 A G 2: 31,453,605 T4642A possibly damaging Het
Hspg2 A G 4: 137,508,389 T167A probably benign Het
Igsf10 A G 3: 59,330,690 L690P probably benign Het
Klhdc10 G A 6: 30,439,866 probably null Het
Krt31 A G 11: 100,048,396 Y232H probably damaging Het
Lsm3 A G 6: 91,516,088 probably benign Het
Mfn2 T A 4: 147,885,490 I375F probably damaging Het
Mfrp A T 9: 44,102,874 I180F probably damaging Het
Msh3 T C 13: 92,349,312 E168G possibly damaging Het
Naa16 A T 14: 79,384,668 V77D probably damaging Het
Nav2 T C 7: 49,558,773 S1570P probably damaging Het
Numa1 C T 7: 102,000,232 R1057* probably null Het
Nup210l G A 3: 90,122,792 A271T probably damaging Het
Ogdh T C 11: 6,355,400 V965A probably damaging Het
Olfr63 C A 17: 33,269,665 Q314K probably benign Het
Olfr734 A T 14: 50,320,016 V273E probably damaging Het
Olfr818 A G 10: 129,945,903 L53P probably damaging Het
Olfr836 A T 9: 19,121,375 N140I probably damaging Het
Olfr916 T A 9: 38,658,066 I109F probably damaging Het
Pdp2 A T 8: 104,594,899 Q460L probably benign Het
Pex5l T C 3: 32,992,992 T270A probably benign Het
Pkp4 C T 2: 59,310,254 Q435* probably null Het
Prss32 G A 17: 23,856,122 V149M probably benign Het
Riox2 C A 16: 59,489,417 P378Q probably benign Het
Rita1 C T 5: 120,609,793 A147T probably damaging Het
Rsph4a T A 10: 33,905,525 S124T possibly damaging Het
Sdccag8 G A 1: 176,824,755 R24H possibly damaging Het
Slc22a1 C A 17: 12,675,500 G54* probably null Het
Slc24a5 C T 2: 125,085,647 probably benign Het
Tex101 C T 7: 24,668,325 V201M probably damaging Het
Tmprss7 T C 16: 45,681,593 Y223C probably damaging Het
Trpc4ap T C 2: 155,650,468 E382G probably damaging Het
Uggt1 A T 1: 36,184,484 Y575N probably damaging Het
Vmn2r70 T C 7: 85,565,168 I259V probably damaging Het
Xpo1 T A 11: 23,277,065 N131K probably damaging Het
Zfp579 C T 7: 4,994,433 V160M probably benign Het
Zfp697 A G 3: 98,425,450 D64G probably benign Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27910890 missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27912264 splice site probably benign
IGL02449:Zfp974 APN 7 27911727 missense probably benign
R0362:Zfp974 UTSW 7 27927394 splice site probably benign
R0372:Zfp974 UTSW 7 27920695 critical splice donor site probably null
R0379:Zfp974 UTSW 7 27910932 missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27911991 missense possibly damaging 0.56
R0791:Zfp974 UTSW 7 27910085 nonsense probably null
R1411:Zfp974 UTSW 7 27911209 missense probably benign 0.00
R1567:Zfp974 UTSW 7 27910723 missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27911081 missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27910356 missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27910356 missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27910356 missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27910441 missense possibly damaging 0.73
R4006:Zfp974 UTSW 7 27912252 missense possibly damaging 0.86
R4303:Zfp974 UTSW 7 27910232 missense possibly damaging 0.85
R4541:Zfp974 UTSW 7 27926404 missense probably damaging 0.99
R4771:Zfp974 UTSW 7 27926308 missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27910819 missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27926290 missense probably benign 0.01
R5537:Zfp974 UTSW 7 27912246 critical splice acceptor site probably benign
R5906:Zfp974 UTSW 7 27910805 missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27910957 missense probably benign 0.01
R6419:Zfp974 UTSW 7 27911515 missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27926403 missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27911649 missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27911519 missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27910438 missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27912134 missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27911685 missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27910712 missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27911272 missense probably damaging 1.00
Posted On2015-04-16