Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02313:Zfp974'

287871

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp974

Ensembl Gene

ENSMUSG00000070709

Gene Name

zinc finger protein 974

Synonyms

1700049G17Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02313

Quality Score

Status

Chromosome

Chromosomal Location

27907392-27929460 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27912253 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 16 (T16A)

Ref Sequence

ENSEMBL: ENSMUSP00000096238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098639
AA Change: T16A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: T16A

Domain	Start	End	E-Value	Type
ZnF_C2H2	99	121	8.81e-2	SMART
ZnF_C2H2	127	149	1.82e-3	SMART
ZnF_C2H2	155	177	3.11e-2	SMART
ZnF_C2H2	201	223	2.15e-5	SMART
ZnF_C2H2	229	251	1.18e-2	SMART
ZnF_C2H2	257	279	1.47e-3	SMART
ZnF_C2H2	285	307	1.79e-2	SMART
ZnF_C2H2	313	335	2.24e-3	SMART
ZnF_C2H2	341	363	9.73e-4	SMART
ZnF_C2H2	369	391	7.26e-3	SMART
ZnF_C2H2	397	419	6.42e-4	SMART
ZnF_C2H2	425	447	3.63e-3	SMART
ZnF_C2H2	453	475	1.28e-3	SMART
ZnF_C2H2	481	503	1.26e-2	SMART
ZnF_C2H2	509	531	1.38e-3	SMART
ZnF_C2H2	537	559	3.83e-2	SMART
ZnF_C2H2	565	587	1.95e-3	SMART
ZnF_C2H2	593	615	4.61e-5	SMART
ZnF_C2H2	621	643	1.95e-3	SMART
ZnF_C2H2	649	671	1.03e-2	SMART
ZnF_C2H2	677	699	5.5e-3	SMART
ZnF_C2H2	705	727	2.37e2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000129341
AA Change: T90A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709
AA Change: T90A

Domain	Start	End	E-Value	Type
KRAB	14	75	7.5e-37	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd13c	T	A	3: 157,947,934	N136K	probably damaging	Het
Aph1b	A	T	9: 66,790,673		probably benign	Het
Atf7ip	A	G	6: 136,606,720	K1250E	probably damaging	Het
Atp8b2	T	C	3: 89,949,853	N400S	probably damaging	Het
Brca2	C	A	5: 150,538,661	S630Y	probably damaging	Het
Chd6	T	A	2: 160,965,675	E1873V	probably damaging	Het
Chrna10	T	C	7: 102,112,029		probably benign	Het
Col6a3	A	G	1: 90,811,606	L907P	probably damaging	Het
Cxcr6	A	G	9: 123,810,705	N264S	probably damaging	Het
Dgkg	A	G	16: 22,570,230		probably benign	Het
Dpysl2	T	G	14: 66,824,390	M256L	probably benign	Het
Dsp	G	T	13: 38,196,523	E1816*	probably null	Het
Fam129c	A	G	8: 71,602,860	R305G	possibly damaging	Het
Fam13b	T	C	18: 34,454,656	K530E	probably damaging	Het
Fam49a	A	G	12: 12,364,751	T248A	possibly damaging	Het
Fastk	T	C	5: 24,443,092	H242R	probably damaging	Het
Fbxw28	A	T	9: 109,337,352	H145Q	possibly damaging	Het
Heatr6	T	C	11: 83,778,892	L910P	probably damaging	Het
Hmcn2	A	G	2: 31,453,605	T4642A	possibly damaging	Het
Hspg2	A	G	4: 137,508,389	T167A	probably benign	Het
Igsf10	A	G	3: 59,330,690	L690P	probably benign	Het
Klhdc10	G	A	6: 30,439,866		probably null	Het
Krt31	A	G	11: 100,048,396	Y232H	probably damaging	Het
Lsm3	A	G	6: 91,516,088		probably benign	Het
Mfn2	T	A	4: 147,885,490	I375F	probably damaging	Het
Mfrp	A	T	9: 44,102,874	I180F	probably damaging	Het
Msh3	T	C	13: 92,349,312	E168G	possibly damaging	Het
Naa16	A	T	14: 79,384,668	V77D	probably damaging	Het
Nav2	T	C	7: 49,558,773	S1570P	probably damaging	Het
Numa1	C	T	7: 102,000,232	R1057*	probably null	Het
Nup210l	G	A	3: 90,122,792	A271T	probably damaging	Het
Ogdh	T	C	11: 6,355,400	V965A	probably damaging	Het
Olfr63	C	A	17: 33,269,665	Q314K	probably benign	Het
Olfr734	A	T	14: 50,320,016	V273E	probably damaging	Het
Olfr818	A	G	10: 129,945,903	L53P	probably damaging	Het
Olfr836	A	T	9: 19,121,375	N140I	probably damaging	Het
Olfr916	T	A	9: 38,658,066	I109F	probably damaging	Het
Pdp2	A	T	8: 104,594,899	Q460L	probably benign	Het
Pex5l	T	C	3: 32,992,992	T270A	probably benign	Het
Pkp4	C	T	2: 59,310,254	Q435*	probably null	Het
Prss32	G	A	17: 23,856,122	V149M	probably benign	Het
Riox2	C	A	16: 59,489,417	P378Q	probably benign	Het
Rita1	C	T	5: 120,609,793	A147T	probably damaging	Het
Rsph4a	T	A	10: 33,905,525	S124T	possibly damaging	Het
Sdccag8	G	A	1: 176,824,755	R24H	possibly damaging	Het
Slc22a1	C	A	17: 12,675,500	G54*	probably null	Het
Slc24a5	C	T	2: 125,085,647		probably benign	Het
Tex101	C	T	7: 24,668,325	V201M	probably damaging	Het
Tmprss7	T	C	16: 45,681,593	Y223C	probably damaging	Het
Trpc4ap	T	C	2: 155,650,468	E382G	probably damaging	Het
Uggt1	A	T	1: 36,184,484	Y575N	probably damaging	Het
Vmn2r70	T	C	7: 85,565,168	I259V	probably damaging	Het
Xpo1	T	A	11: 23,277,065	N131K	probably damaging	Het
Zfp579	C	T	7: 4,994,433	V160M	probably benign	Het
Zfp697	A	G	3: 98,425,450	D64G	probably benign	Het

Other mutations in Zfp974

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00836:Zfp974	APN	7	27910890	missense	possibly damaging	0.83
IGL01805:Zfp974	APN	7	27912264	splice site	probably benign
IGL02449:Zfp974	APN	7	27911727	missense	probably benign
R0362:Zfp974	UTSW	7	27927394	splice site	probably benign
R0372:Zfp974	UTSW	7	27920695	critical splice donor site	probably null
R0379:Zfp974	UTSW	7	27910932	missense	probably damaging	0.98
R0699:Zfp974	UTSW	7	27911991	missense	possibly damaging	0.56
R0791:Zfp974	UTSW	7	27910085	nonsense	probably null
R1411:Zfp974	UTSW	7	27911209	missense	probably benign	0.00
R1567:Zfp974	UTSW	7	27910723	missense	probably damaging	0.99
R1747:Zfp974	UTSW	7	27911081	missense	possibly damaging	0.61
R1837:Zfp974	UTSW	7	27910356	missense	possibly damaging	0.93
R1838:Zfp974	UTSW	7	27910356	missense	possibly damaging	0.93
R1839:Zfp974	UTSW	7	27910356	missense	possibly damaging	0.93
R2311:Zfp974	UTSW	7	27910441	missense	possibly damaging	0.73
R4006:Zfp974	UTSW	7	27912252	missense	possibly damaging	0.86
R4303:Zfp974	UTSW	7	27910232	missense	possibly damaging	0.85
R4541:Zfp974	UTSW	7	27926404	missense	probably damaging	0.99
R4771:Zfp974	UTSW	7	27926308	missense	probably damaging	0.96
R4889:Zfp974	UTSW	7	27910819	missense	possibly damaging	0.86
R5332:Zfp974	UTSW	7	27926290	missense	probably benign	0.01
R5537:Zfp974	UTSW	7	27912246	critical splice acceptor site	probably benign
R5906:Zfp974	UTSW	7	27910805	missense	possibly damaging	0.72
R5908:Zfp974	UTSW	7	27910957	missense	probably benign	0.01
R6419:Zfp974	UTSW	7	27911515	missense	possibly damaging	0.72
R6654:Zfp974	UTSW	7	27926403	missense	probably damaging	1.00
R6731:Zfp974	UTSW	7	27911649	missense	possibly damaging	0.93
R7162:Zfp974	UTSW	7	27911519	missense	possibly damaging	0.71
R7316:Zfp974	UTSW	7	27910438	missense	possibly damaging	0.93
R7484:Zfp974	UTSW	7	27912134	missense	possibly damaging	0.72
R7663:Zfp974	UTSW	7	27911685	missense	possibly damaging	0.74
R7664:Zfp974	UTSW	7	27910712	missense	possibly damaging	0.86
R8052:Zfp974	UTSW	7	27911272	missense	probably damaging	1.00

Posted On

2015-04-16