Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02313:Vmn2r70'

287876

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r70

Ensembl Gene

ENSMUSG00000090806

Gene Name

vomeronasal 2, receptor 70

Synonyms

EG620835

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

IGL02313

Quality Score

Status

Chromosome

Chromosomal Location

85558703-85569088 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85565168 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 259 (I259V)

Ref Sequence

ENSEMBL: ENSMUSP00000129703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168230]

AlphaFold

K7N702

Predicted Effect

probably damaging
Transcript: ENSMUST00000168230
AA Change: I259V

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: I259V

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.5e-28	PFAM
Pfam:NCD3G	510	562	1.5e-19	PFAM
Pfam:7tm_3	592	830	1.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd13c	T	A	3: 157,947,934	N136K	probably damaging	Het
Aph1b	A	T	9: 66,790,673		probably benign	Het
Atf7ip	A	G	6: 136,606,720	K1250E	probably damaging	Het
Atp8b2	T	C	3: 89,949,853	N400S	probably damaging	Het
Brca2	C	A	5: 150,538,661	S630Y	probably damaging	Het
Chd6	T	A	2: 160,965,675	E1873V	probably damaging	Het
Chrna10	T	C	7: 102,112,029		probably benign	Het
Col6a3	A	G	1: 90,811,606	L907P	probably damaging	Het
Cxcr6	A	G	9: 123,810,705	N264S	probably damaging	Het
Dgkg	A	G	16: 22,570,230		probably benign	Het
Dpysl2	T	G	14: 66,824,390	M256L	probably benign	Het
Dsp	G	T	13: 38,196,523	E1816*	probably null	Het
Fam129c	A	G	8: 71,602,860	R305G	possibly damaging	Het
Fam13b	T	C	18: 34,454,656	K530E	probably damaging	Het
Fam49a	A	G	12: 12,364,751	T248A	possibly damaging	Het
Fastk	T	C	5: 24,443,092	H242R	probably damaging	Het
Fbxw28	A	T	9: 109,337,352	H145Q	possibly damaging	Het
Heatr6	T	C	11: 83,778,892	L910P	probably damaging	Het
Hmcn2	A	G	2: 31,453,605	T4642A	possibly damaging	Het
Hspg2	A	G	4: 137,508,389	T167A	probably benign	Het
Igsf10	A	G	3: 59,330,690	L690P	probably benign	Het
Klhdc10	G	A	6: 30,439,866		probably null	Het
Krt31	A	G	11: 100,048,396	Y232H	probably damaging	Het
Lsm3	A	G	6: 91,516,088		probably benign	Het
Mfn2	T	A	4: 147,885,490	I375F	probably damaging	Het
Mfrp	A	T	9: 44,102,874	I180F	probably damaging	Het
Msh3	T	C	13: 92,349,312	E168G	possibly damaging	Het
Naa16	A	T	14: 79,384,668	V77D	probably damaging	Het
Nav2	T	C	7: 49,558,773	S1570P	probably damaging	Het
Numa1	C	T	7: 102,000,232	R1057*	probably null	Het
Nup210l	G	A	3: 90,122,792	A271T	probably damaging	Het
Ogdh	T	C	11: 6,355,400	V965A	probably damaging	Het
Olfr63	C	A	17: 33,269,665	Q314K	probably benign	Het
Olfr734	A	T	14: 50,320,016	V273E	probably damaging	Het
Olfr818	A	G	10: 129,945,903	L53P	probably damaging	Het
Olfr836	A	T	9: 19,121,375	N140I	probably damaging	Het
Olfr916	T	A	9: 38,658,066	I109F	probably damaging	Het
Pdp2	A	T	8: 104,594,899	Q460L	probably benign	Het
Pex5l	T	C	3: 32,992,992	T270A	probably benign	Het
Pkp4	C	T	2: 59,310,254	Q435*	probably null	Het
Prss32	G	A	17: 23,856,122	V149M	probably benign	Het
Riox2	C	A	16: 59,489,417	P378Q	probably benign	Het
Rita1	C	T	5: 120,609,793	A147T	probably damaging	Het
Rsph4a	T	A	10: 33,905,525	S124T	possibly damaging	Het
Sdccag8	G	A	1: 176,824,755	R24H	possibly damaging	Het
Slc22a1	C	A	17: 12,675,500	G54*	probably null	Het
Slc24a5	C	T	2: 125,085,647		probably benign	Het
Tex101	C	T	7: 24,668,325	V201M	probably damaging	Het
Tmprss7	T	C	16: 45,681,593	Y223C	probably damaging	Het
Trpc4ap	T	C	2: 155,650,468	E382G	probably damaging	Het
Uggt1	A	T	1: 36,184,484	Y575N	probably damaging	Het
Xpo1	T	A	11: 23,277,065	N131K	probably damaging	Het
Zfp579	C	T	7: 4,994,433	V160M	probably benign	Het
Zfp697	A	G	3: 98,425,450	D64G	probably benign	Het
Zfp974	T	C	7: 27,912,253	T16A	possibly damaging	Het

Other mutations in Vmn2r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Vmn2r70	APN	7	85563799	missense	probably benign	0.00
IGL01140:Vmn2r70	APN	7	85565171	nonsense	probably null
IGL01287:Vmn2r70	APN	7	85569019	nonsense	probably null
IGL01581:Vmn2r70	APN	7	85563914	splice site	probably null
IGL01632:Vmn2r70	APN	7	85566072	missense	probably benign	0.00
IGL01725:Vmn2r70	APN	7	85559386	missense	probably damaging	1.00
IGL02244:Vmn2r70	APN	7	85565003	missense	probably benign
IGL02288:Vmn2r70	APN	7	85565134	missense	probably benign	0.31
IGL02591:Vmn2r70	APN	7	85564945	missense	probably damaging	0.96
IGL02725:Vmn2r70	APN	7	85565345	missense	possibly damaging	0.46
IGL02797:Vmn2r70	APN	7	85559087	missense	probably benign	0.00
R0045:Vmn2r70	UTSW	7	85566044	missense	probably damaging	1.00
R0729:Vmn2r70	UTSW	7	85565904	missense	probably benign	0.00
R0967:Vmn2r70	UTSW	7	85559619	missense	probably damaging	0.99
R1217:Vmn2r70	UTSW	7	85559061	missense	probably damaging	1.00
R1351:Vmn2r70	UTSW	7	85565054	missense	probably damaging	1.00
R1387:Vmn2r70	UTSW	7	85558761	missense	probably benign	0.12
R1483:Vmn2r70	UTSW	7	85559167	missense	probably benign	0.04
R1796:Vmn2r70	UTSW	7	85563803	nonsense	probably null
R1809:Vmn2r70	UTSW	7	85565922	missense	probably benign	0.23
R2154:Vmn2r70	UTSW	7	85563715	missense	possibly damaging	0.67
R2173:Vmn2r70	UTSW	7	85565082	missense	probably benign
R2334:Vmn2r70	UTSW	7	85559592	missense	probably benign	0.05
R2871:Vmn2r70	UTSW	7	85559019	missense	probably damaging	1.00
R2871:Vmn2r70	UTSW	7	85559019	missense	probably damaging	1.00
R3975:Vmn2r70	UTSW	7	85559332	missense	probably benign	0.00
R4525:Vmn2r70	UTSW	7	85559579	missense	probably damaging	1.00
R4527:Vmn2r70	UTSW	7	85559579	missense	probably damaging	1.00
R4535:Vmn2r70	UTSW	7	85565333	missense	probably damaging	1.00
R5181:Vmn2r70	UTSW	7	85559179	missense	probably damaging	0.99
R5600:Vmn2r70	UTSW	7	85563727	missense	probably benign	0.07
R5641:Vmn2r70	UTSW	7	85559364	missense	probably damaging	0.99
R5726:Vmn2r70	UTSW	7	85559107	missense	probably damaging	1.00
R5943:Vmn2r70	UTSW	7	85565991	missense	probably benign	0.09
R6166:Vmn2r70	UTSW	7	85565981	missense	probably benign	0.25
R6272:Vmn2r70	UTSW	7	85558986	missense	probably damaging	1.00
R6324:Vmn2r70	UTSW	7	85558879	missense	probably benign	0.01
R6429:Vmn2r70	UTSW	7	85559068	missense	probably damaging	1.00
R6449:Vmn2r70	UTSW	7	85564949	missense	probably damaging	1.00
R6512:Vmn2r70	UTSW	7	85566097	missense	probably benign
R7000:Vmn2r70	UTSW	7	85559611	missense	probably damaging	0.99
R7141:Vmn2r70	UTSW	7	85558836	missense	probably benign
R7153:Vmn2r70	UTSW	7	85565054	missense	probably damaging	1.00
R7424:Vmn2r70	UTSW	7	85563868	missense	probably damaging	1.00
R7565:Vmn2r70	UTSW	7	85565291	missense	probably benign	0.35
R7567:Vmn2r70	UTSW	7	85565035	missense	probably benign	0.41
R7593:Vmn2r70	UTSW	7	85566104	nonsense	probably null
R7660:Vmn2r70	UTSW	7	85568922	missense	probably damaging	0.99
R7806:Vmn2r70	UTSW	7	85559193	missense	probably benign
R7892:Vmn2r70	UTSW	7	85559380	missense	possibly damaging	0.58
R7965:Vmn2r70	UTSW	7	85561863	missense	probably damaging	0.96
R8052:Vmn2r70	UTSW	7	85563715	missense	probably benign
R8251:Vmn2r70	UTSW	7	85565978	nonsense	probably null
R8814:Vmn2r70	UTSW	7	85565961	missense	probably benign	0.00
R8934:Vmn2r70	UTSW	7	85561980	missense	possibly damaging	0.87
R9225:Vmn2r70	UTSW	7	85559034	missense	probably damaging	1.00
R9322:Vmn2r70	UTSW	7	85559290	missense	possibly damaging	0.92
R9430:Vmn2r70	UTSW	7	85566032	missense	probably benign	0.10
R9477:Vmn2r70	UTSW	7	85569036	missense	possibly damaging	0.50
Z1088:Vmn2r70	UTSW	7	85564760	missense	possibly damaging	0.53
Z1176:Vmn2r70	UTSW	7	85569045	missense	probably benign	0.00

Posted On

2015-04-16