Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02313:Zfp579'

287912

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp579

Ensembl Gene

ENSMUSG00000051550

Gene Name

zinc finger protein 579

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02313

Quality Score

Status

Chromosome

Chromosomal Location

4983483-4996158 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 4994433 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 160 (V160M)

Ref Sequence

ENSEMBL: ENSMUSP00000124074 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108572] [ENSMUST00000162502] [ENSMUST00000162731]

AlphaFold

Q80VM4

Predicted Effect

probably benign
Transcript: ENSMUST00000108572
AA Change: V160M

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000104212
Gene: ENSMUSG00000051550
AA Change: V160M

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
low complexity region	189	216	N/A	INTRINSIC
low complexity region	250	262	N/A	INTRINSIC
ZnF_C2H2	267	289	1.36e-2	SMART
ZnF_C2H2	295	317	5.14e-3	SMART
low complexity region	318	368	N/A	INTRINSIC
ZnF_C2H2	382	404	4.34e0	SMART
ZnF_C2H2	410	432	5.06e-2	SMART
ZnF_C2H2	439	461	1.92e-2	SMART
low complexity region	462	492	N/A	INTRINSIC
low complexity region	511	525	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159754

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160225

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160808

Predicted Effect

probably benign
Transcript: ENSMUST00000162502
AA Change: V160M

PolyPhen 2 Score 0.230 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000124074
Gene: ENSMUSG00000051550
AA Change: V160M

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
coiled coil region	190	213	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162731
AA Change: V160M

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000123963
Gene: ENSMUSG00000051550
AA Change: V160M

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
low complexity region	189	216	N/A	INTRINSIC
low complexity region	250	262	N/A	INTRINSIC
ZnF_C2H2	267	289	1.36e-2	SMART
ZnF_C2H2	295	317	5.14e-3	SMART
low complexity region	318	368	N/A	INTRINSIC
ZnF_C2H2	382	404	4.34e0	SMART
ZnF_C2H2	410	432	5.06e-2	SMART
ZnF_C2H2	439	461	1.92e-2	SMART
low complexity region	462	492	N/A	INTRINSIC
low complexity region	511	525	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd13c	T	A	3: 157,947,934	N136K	probably damaging	Het
Aph1b	A	T	9: 66,790,673		probably benign	Het
Atf7ip	A	G	6: 136,606,720	K1250E	probably damaging	Het
Atp8b2	T	C	3: 89,949,853	N400S	probably damaging	Het
Brca2	C	A	5: 150,538,661	S630Y	probably damaging	Het
Chd6	T	A	2: 160,965,675	E1873V	probably damaging	Het
Chrna10	T	C	7: 102,112,029		probably benign	Het
Col6a3	A	G	1: 90,811,606	L907P	probably damaging	Het
Cxcr6	A	G	9: 123,810,705	N264S	probably damaging	Het
Dgkg	A	G	16: 22,570,230		probably benign	Het
Dpysl2	T	G	14: 66,824,390	M256L	probably benign	Het
Dsp	G	T	13: 38,196,523	E1816*	probably null	Het
Fam129c	A	G	8: 71,602,860	R305G	possibly damaging	Het
Fam13b	T	C	18: 34,454,656	K530E	probably damaging	Het
Fam49a	A	G	12: 12,364,751	T248A	possibly damaging	Het
Fastk	T	C	5: 24,443,092	H242R	probably damaging	Het
Fbxw28	A	T	9: 109,337,352	H145Q	possibly damaging	Het
Heatr6	T	C	11: 83,778,892	L910P	probably damaging	Het
Hmcn2	A	G	2: 31,453,605	T4642A	possibly damaging	Het
Hspg2	A	G	4: 137,508,389	T167A	probably benign	Het
Igsf10	A	G	3: 59,330,690	L690P	probably benign	Het
Klhdc10	G	A	6: 30,439,866		probably null	Het
Krt31	A	G	11: 100,048,396	Y232H	probably damaging	Het
Lsm3	A	G	6: 91,516,088		probably benign	Het
Mfn2	T	A	4: 147,885,490	I375F	probably damaging	Het
Mfrp	A	T	9: 44,102,874	I180F	probably damaging	Het
Msh3	T	C	13: 92,349,312	E168G	possibly damaging	Het
Naa16	A	T	14: 79,384,668	V77D	probably damaging	Het
Nav2	T	C	7: 49,558,773	S1570P	probably damaging	Het
Numa1	C	T	7: 102,000,232	R1057*	probably null	Het
Nup210l	G	A	3: 90,122,792	A271T	probably damaging	Het
Ogdh	T	C	11: 6,355,400	V965A	probably damaging	Het
Olfr63	C	A	17: 33,269,665	Q314K	probably benign	Het
Olfr734	A	T	14: 50,320,016	V273E	probably damaging	Het
Olfr818	A	G	10: 129,945,903	L53P	probably damaging	Het
Olfr836	A	T	9: 19,121,375	N140I	probably damaging	Het
Olfr916	T	A	9: 38,658,066	I109F	probably damaging	Het
Pdp2	A	T	8: 104,594,899	Q460L	probably benign	Het
Pex5l	T	C	3: 32,992,992	T270A	probably benign	Het
Pkp4	C	T	2: 59,310,254	Q435*	probably null	Het
Prss32	G	A	17: 23,856,122	V149M	probably benign	Het
Riox2	C	A	16: 59,489,417	P378Q	probably benign	Het
Rita1	C	T	5: 120,609,793	A147T	probably damaging	Het
Rsph4a	T	A	10: 33,905,525	S124T	possibly damaging	Het
Sdccag8	G	A	1: 176,824,755	R24H	possibly damaging	Het
Slc22a1	C	A	17: 12,675,500	G54*	probably null	Het
Slc24a5	C	T	2: 125,085,647		probably benign	Het
Tex101	C	T	7: 24,668,325	V201M	probably damaging	Het
Tmprss7	T	C	16: 45,681,593	Y223C	probably damaging	Het
Trpc4ap	T	C	2: 155,650,468	E382G	probably damaging	Het
Uggt1	A	T	1: 36,184,484	Y575N	probably damaging	Het
Vmn2r70	T	C	7: 85,565,168	I259V	probably damaging	Het
Xpo1	T	A	11: 23,277,065	N131K	probably damaging	Het
Zfp697	A	G	3: 98,425,450	D64G	probably benign	Het
Zfp974	T	C	7: 27,912,253	T16A	possibly damaging	Het

Other mutations in Zfp579

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00971:Zfp579	APN	7	4993391	missense	probably damaging	0.97
IGL01121:Zfp579	APN	7	4993247	missense	possibly damaging	0.59
IGL01475:Zfp579	APN	7	4994744	missense	probably benign	0.32
IGL01866:Zfp579	APN	7	4994258	missense	possibly damaging	0.88
IGL02284:Zfp579	APN	7	4994168	missense	probably damaging	0.99
R1803:Zfp579	UTSW	7	4993770	missense	probably damaging	1.00
R2025:Zfp579	UTSW	7	4993521	nonsense	probably null
R2026:Zfp579	UTSW	7	4993521	nonsense	probably null
R2027:Zfp579	UTSW	7	4993521	nonsense	probably null
R3690:Zfp579	UTSW	7	4994720	missense	probably damaging	0.99
R4303:Zfp579	UTSW	7	4993073	utr 3 prime	probably benign
R6680:Zfp579	UTSW	7	4993502	missense	probably damaging	0.99
R6826:Zfp579	UTSW	7	4994426	missense	probably benign	0.01
R6869:Zfp579	UTSW	7	4994461	missense	probably benign	0.00
R7304:Zfp579	UTSW	7	4994583	missense	probably benign	0.22
R8220:Zfp579	UTSW	7	4993851	missense	probably benign	0.15
R8328:Zfp579	UTSW	7	4994867	missense	unknown
X0028:Zfp579	UTSW	7	4993933	missense	probably damaging	0.99

Posted On

2015-04-16