Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02314:Scly'

287957

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scly

Ensembl Gene

ENSMUSG00000026307

Gene Name

selenocysteine lyase

Synonyms

SCL, A930015N15Rik, Selenocysteine reductase, Scly2, Scly1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL02314

Quality Score

Status

Chromosome

Chromosomal Location

91226060-91248797 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 91246763 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 358 (Y358C)

Ref Sequence

ENSEMBL: ENSMUSP00000027532 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027532] [ENSMUST00000088904] [ENSMUST00000176156]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000027532
AA Change: Y358C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000027532
Gene: ENSMUSG00000026307
AA Change: Y358C

Domain	Start	End	E-Value	Type
Pfam:Aminotran_5	20	417	1.7e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000088904

SMART Domains

Protein: ENSMUSP00000086294
Gene: ENSMUSG00000049515

Domain	Start	End	E-Value	Type
Blast:ANK	1	33	4e-7	BLAST
ANK	35	64	5.21e1	SMART
ANK	69	102	2.88e2	SMART
ANK	103	132	3.85e-2	SMART
ANK	136	166	7.08e-1	SMART
ANK	170	200	1.02e-1	SMART
ANK	204	232	3.04e0	SMART
ANK	238	267	5.01e-1	SMART
ANK	270	299	1.96e-3	SMART
ANK	303	332	3.21e1	SMART
low complexity region	336	345	N/A	INTRINSIC
coiled coil region	509	538	N/A	INTRINSIC
low complexity region	820	833	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000171768

Predicted Effect

probably benign
Transcript: ENSMUST00000176156

SMART Domains

Protein: ENSMUSP00000135828
Gene: ENSMUSG00000049515

Domain	Start	End	E-Value	Type
Blast:ANK	1	33	5e-7	BLAST
ANK	35	64	5.21e1	SMART
ANK	69	102	2.88e2	SMART
ANK	103	132	3.85e-2	SMART
ANK	136	166	7.08e-1	SMART
ANK	170	200	1.02e-1	SMART
ANK	204	232	3.04e0	SMART
ANK	238	267	5.01e-1	SMART
low complexity region	292	301	N/A	INTRINSIC
coiled coil region	465	494	N/A	INTRINSIC
low complexity region	776	789	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice fed a selenium-deficient diet exhibit mild learning impairment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alg2	T	A	4: 47,472,143 (GRCm39)	K94*	probably null	Het
Axl	A	G	7: 25,486,345 (GRCm39)	F120L	possibly damaging	Het
Baz2b	A	G	2: 59,792,571 (GRCm39)	V519A	probably benign	Het
Cdk2	A	T	10: 128,539,595 (GRCm39)	I99N	probably damaging	Het
Ces1b	C	A	8: 93,791,524 (GRCm39)	W358C	possibly damaging	Het
Cimap1b	T	G	15: 89,262,372 (GRCm39)	K82N	probably damaging	Het
Clca3b	A	G	3: 144,533,903 (GRCm39)		probably benign	Het
Col6a4	T	G	9: 105,874,355 (GRCm39)	T2211P	probably damaging	Het
Cyp4f14	C	T	17: 33,125,265 (GRCm39)	E438K	probably benign	Het
Dpy19l4	T	A	4: 11,267,720 (GRCm39)	T407S	possibly damaging	Het
Dtx3	G	A	10: 127,026,828 (GRCm39)		probably benign	Het
Eif1ad14	T	A	12: 87,886,377 (GRCm39)	Y84F	probably benign	Het
Fat3	A	T	9: 15,881,134 (GRCm39)	L3246H	possibly damaging	Het
Fat4	A	T	3: 38,941,779 (GRCm39)	D224V	probably damaging	Het
Fndc9	A	T	11: 46,129,122 (GRCm39)	I214F	probably benign	Het
Foxred1	A	T	9: 35,117,264 (GRCm39)	I22N	probably damaging	Het
Gkn1	T	C	6: 87,326,103 (GRCm39)	D29G	probably benign	Het
Gng11	T	A	6: 4,004,317 (GRCm39)	M1K	probably null	Het
Hdac7	T	C	15: 97,706,885 (GRCm39)	D237G	probably damaging	Het
Hgf	A	G	5: 16,777,600 (GRCm39)	Y199C	probably damaging	Het
Hgfac	A	T	5: 35,198,941 (GRCm39)	M1L	probably benign	Het
Hsd17b6	T	C	10: 127,833,777 (GRCm39)	T35A	probably damaging	Het
Htr3a	G	A	9: 48,815,927 (GRCm39)	P170L	probably damaging	Het
Ighv12-3	A	G	12: 114,330,421 (GRCm39)	S25P	probably damaging	Het
Jph2	A	T	2: 163,239,273 (GRCm39)	N58K	probably damaging	Het
Lama5	A	G	2: 179,836,275 (GRCm39)		probably benign	Het
Lpin3	T	A	2: 160,740,638 (GRCm39)	Y394*	probably null	Het
Macf1	G	T	4: 123,338,630 (GRCm39)	T2248K	probably damaging	Het
Map3k2	A	G	18: 32,351,553 (GRCm39)		probably benign	Het
Map4k5	G	A	12: 69,865,213 (GRCm39)	P524S	probably benign	Het
Mcf2l	C	T	8: 13,051,851 (GRCm39)	S359L	probably damaging	Het
Mdh1b	C	T	1: 63,750,273 (GRCm39)		probably null	Het
Mfhas1	G	A	8: 36,055,927 (GRCm39)	R134H	probably damaging	Het
Mogs	A	G	6: 83,095,036 (GRCm39)	T618A	probably benign	Het
Mybpc2	T	A	7: 44,171,812 (GRCm39)	Q39H	possibly damaging	Het
Myoc	C	T	1: 162,466,917 (GRCm39)	R29W	probably damaging	Het
Nae1	A	G	8: 105,252,938 (GRCm39)	M162T	probably damaging	Het
Nfatc3	A	G	8: 106,805,532 (GRCm39)	I126V	probably benign	Het
Nxnl2	C	A	13: 51,325,565 (GRCm39)	F69L	probably benign	Het
Oca2	T	A	7: 56,006,899 (GRCm39)	I662N	probably benign	Het
Or52b3	A	T	7: 102,204,318 (GRCm39)	I276F	probably damaging	Het
Or5w8	A	G	2: 87,688,400 (GRCm39)	N294D	probably damaging	Het
Or7c70	A	T	10: 78,683,099 (GRCm39)	S217T	probably damaging	Het
Or7e176	A	T	9: 20,171,774 (GRCm39)	I213L	probably benign	Het
Pcdhb14	G	A	18: 37,583,248 (GRCm39)	E785K	probably benign	Het
Plb1	A	C	5: 32,438,492 (GRCm39)	Y209S	possibly damaging	Het
Pramel24	T	C	4: 143,455,012 (GRCm39)	S437P	probably benign	Het
Rab44	C	A	17: 29,358,327 (GRCm39)	Q172K	probably benign	Het
Rnf214	A	T	9: 45,811,105 (GRCm39)	V186E	probably benign	Het
Rps6ka1	C	A	4: 133,578,065 (GRCm39)	G522W	probably damaging	Het
Samhd1	G	T	2: 156,976,948 (GRCm39)	T21K	probably damaging	Het
Sfxn2	A	G	19: 46,571,026 (GRCm39)	N29D	possibly damaging	Het
Shank2	A	G	7: 143,965,008 (GRCm39)	D1451G	probably benign	Het
Slc44a5	G	A	3: 153,962,156 (GRCm39)	S363N	probably damaging	Het
Smg1	A	G	7: 117,753,932 (GRCm39)		probably benign	Het
Tas1r3	A	T	4: 155,945,119 (GRCm39)	C701S	probably damaging	Het
Tmem87a	A	G	2: 120,234,502 (GRCm39)	S14P	possibly damaging	Het
Trmt6	G	A	2: 132,647,378 (GRCm39)	A486V	probably benign	Het
Ttn	G	A	2: 76,727,091 (GRCm39)	R1602*	probably null	Het
Ush2a	A	G	1: 188,365,826 (GRCm39)	M2227V	probably benign	Het
Vmn2r96	A	T	17: 18,804,221 (GRCm39)	Q490H	probably benign	Het
Wdr19	G	T	5: 65,414,463 (GRCm39)	A1279S	probably benign	Het
Zbtb7c	G	A	18: 76,278,937 (GRCm39)	R465H	probably damaging	Het
Zfp473	T	C	7: 44,383,353 (GRCm39)	S326G	probably benign	Het

Other mutations in Scly

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02690:Scly	APN	1	91,233,047 (GRCm39)	missense	probably benign
R0597:Scly	UTSW	1	91,237,555 (GRCm39)	missense	probably damaging	1.00
R1782:Scly	UTSW	1	91,236,102 (GRCm39)	missense	probably damaging	1.00
R1950:Scly	UTSW	1	91,233,116 (GRCm39)	missense	probably benign	0.08
R1978:Scly	UTSW	1	91,247,891 (GRCm39)	missense	probably damaging	0.98
R2290:Scly	UTSW	1	91,226,172 (GRCm39)	critical splice donor site	probably null
R3861:Scly	UTSW	1	91,230,573 (GRCm39)	utr 3 prime	probably benign
R4508:Scly	UTSW	1	91,236,047 (GRCm39)	missense	possibly damaging	0.95
R4876:Scly	UTSW	1	91,247,850 (GRCm39)	missense	probably damaging	0.98
R7035:Scly	UTSW	1	91,236,125 (GRCm39)	missense	probably damaging	0.98
R7701:Scly	UTSW	1	91,236,030 (GRCm39)	missense
R7887:Scly	UTSW	1	91,228,363 (GRCm39)	critical splice donor site	probably null
R8079:Scly	UTSW	1	91,236,089 (GRCm39)	missense	probably damaging	0.99
R8501:Scly	UTSW	1	91,246,798 (GRCm39)	missense	probably damaging	1.00
R8828:Scly	UTSW	1	91,244,830 (GRCm39)	missense	possibly damaging	0.83
R9533:Scly	UTSW	1	91,228,413 (GRCm39)	intron	probably benign
X0021:Scly	UTSW	1	91,247,828 (GRCm39)	missense	probably damaging	0.98
Z1176:Scly	UTSW	1	91,233,035 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16