Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02318:Olfr134'

288097

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr134

Ensembl Gene

ENSMUSG00000096009

Gene Name

olfactory receptor 134

Synonyms

MOR256-5, GA_x6K02T2PSCP-2623613-2624551

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.335) question?

Stock #

IGL02318

Quality Score

Status

Chromosome

Chromosomal Location

38171388-38176578 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 38175686 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 201 (V201L)

Ref Sequence

ENSEMBL: ENSMUSP00000151069 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074883] [ENSMUST00000215900]

AlphaFold

Q8VG95

Predicted Effect

probably benign
Transcript: ENSMUST00000074883
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000074423
Gene: ENSMUSG00000096009
AA Change: V201L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.4e-50	PFAM
Pfam:7tm_1	41	290	2e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215900
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	A	G	5: 138,563,576	F116S	probably damaging	Het
2410089E03Rik	A	G	15: 8,175,025	K96E	probably damaging	Het
4930467E23Rik	T	C	8: 19,747,799		probably null	Het
Abhd18	G	A	3: 40,930,227		probably null	Het
Akr1c6	G	T	13: 4,438,497	C34F	probably benign	Het
Ankef1	T	A	2: 136,544,775	I180N	possibly damaging	Het
Ap1b1	G	A	11: 5,019,294	V217I	probably benign	Het
Arhgap27	T	C	11: 103,333,163	Q608R	probably benign	Het
Arhgap32	A	G	9: 32,259,331	T1136A	probably benign	Het
Ascc3	T	A	10: 50,728,154	Y1323*	probably null	Het
Bsx	A	C	9: 40,874,221	Q15P	probably benign	Het
Cdh20	A	G	1: 104,954,039	I410V	probably null	Het
Col20a1	A	G	2: 181,007,159	D945G	probably damaging	Het
Cox20	A	G	1: 178,322,478		probably null	Het
Cpne9	A	G	6: 113,293,738	D305G	possibly damaging	Het
Cyp2d12	A	G	15: 82,555,243	T33A	probably benign	Het
Dvl3	A	G	16: 20,523,743	R149G	possibly damaging	Het
Dysf	A	G	6: 84,186,464	I1624V	possibly damaging	Het
Echs1	A	T	7: 140,111,710	L167Q	probably damaging	Het
Ect2	A	T	3: 27,138,719	N358K	probably benign	Het
Eml4	A	G	17: 83,441,366	I230V	probably benign	Het
Fut10	A	G	8: 31,236,258	Y347C	probably damaging	Het
Gfm2	C	A	13: 97,162,975	N401K	probably damaging	Het
Gm4788	T	A	1: 139,781,097	E24D	probably benign	Het
Gm4795	C	T	10: 45,006,639		noncoding transcript	Het
Gm5592	C	A	7: 41,286,788	T238N	probably benign	Het
Gm9892	T	C	8: 52,196,225		noncoding transcript	Het
Greb1l	G	T	18: 10,469,388	M134I	possibly damaging	Het
Grk3	A	G	5: 112,937,803	Y314H	probably damaging	Het
Hrh2	T	C	13: 54,214,650	I215T	probably damaging	Het
Ilkap	A	G	1: 91,385,238		probably null	Het
Inpp4a	T	C	1: 37,368,303	Y233H	probably damaging	Het
Itgb4	G	A	11: 115,988,926	V635I	probably damaging	Het
Lmo7	C	T	14: 101,900,066		probably benign	Het
Luc7l3	C	T	11: 94,292,993	R440Q	probably benign	Het
Mis18bp1	A	C	12: 65,158,741	I219S	probably benign	Het
Myo9b	G	A	8: 71,354,124	E1581K	probably damaging	Het
Nfs1	T	A	2: 156,124,271	Q458L	probably damaging	Het
Numb	A	T	12: 83,831,918		probably null	Het
Nxf1	G	A	19: 8,764,150		probably null	Het
Olfr67	A	G	7: 103,788,268	V3A	probably benign	Het
Pde2a	A	T	7: 101,503,343	Y371F	possibly damaging	Het
Phlpp2	G	T	8: 109,939,873	L1011F	probably benign	Het
Prss27	G	T	17: 24,045,597	V245L	probably benign	Het
Rbm7	T	C	9: 48,494,111	N56S	probably damaging	Het
Rftn1	T	C	17: 50,036,970	I97V	possibly damaging	Het
Ric3	T	C	7: 109,048,080	T178A	probably damaging	Het
Rock1	A	G	18: 10,104,323		probably benign	Het
Sall2	T	C	14: 52,315,565	T56A	probably damaging	Het
Sgk1	T	C	10: 21,995,541	S60P	probably damaging	Het
Smarcad1	G	A	6: 65,073,239	A281T	probably damaging	Het
Spta1	A	G	1: 174,174,463	H53R	possibly damaging	Het
Thbs4	T	C	13: 92,763,584	D468G	probably damaging	Het
Tmem108	A	T	9: 103,499,782	V156E	probably benign	Het
Tmem206	A	G	1: 191,348,408	E275G	possibly damaging	Het
Tnfaip3	T	G	10: 19,004,467	R617S	probably benign	Het
Traf3	A	G	12: 111,237,597	M7V	probably benign	Het
Ubr3	T	A	2: 69,979,397	I1237N	probably damaging	Het
Vmn2r23	T	C	6: 123,741,836	V716A	probably benign	Het

Other mutations in Olfr134

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01677:Olfr134	APN	17	38175875	missense	probably damaging	1.00
IGL01749:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01750:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01751:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01753:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01757:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01765:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01766:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01767:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL01822:Olfr134	APN	17	38175448	missense	probably damaging	1.00
IGL02256:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02257:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02258:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02259:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02275:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02293:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02295:Olfr134	APN	17	38175686	missense	probably benign	0.04
IGL02317:Olfr134	APN	17	38175686	missense	probably benign	0.04
R0230:Olfr134	UTSW	17	38175950	missense	probably damaging	1.00
R0363:Olfr134	UTSW	17	38175447	missense	probably damaging	1.00
R1074:Olfr134	UTSW	17	38175440	missense	probably damaging	1.00
R1506:Olfr134	UTSW	17	38175200	missense	probably benign
R2300:Olfr134	UTSW	17	38175550	nonsense	probably null
R3743:Olfr134	UTSW	17	38175902	missense	probably damaging	1.00
R3975:Olfr134	UTSW	17	38175495	missense	probably benign	0.03
R4230:Olfr134	UTSW	17	38175881	missense	possibly damaging	0.67
R5158:Olfr134	UTSW	17	38175454	nonsense	probably null
R5439:Olfr134	UTSW	17	38176026	splice site	probably null
R6144:Olfr134	UTSW	17	38175225	missense	probably damaging	1.00
R6309:Olfr134	UTSW	17	38175519	missense	probably benign	0.00
R6675:Olfr134	UTSW	17	38176014	missense	probably benign
R6800:Olfr134	UTSW	17	38175122	missense	probably benign	0.01
R6873:Olfr134	UTSW	17	38175368	missense	probably benign
R7193:Olfr134	UTSW	17	38175096	missense	probably benign	0.44
R7534:Olfr134	UTSW	17	38175297	missense	probably benign	0.22
R7869:Olfr134	UTSW	17	38175939	missense	possibly damaging	0.94
R7912:Olfr134	UTSW	17	38175267	missense	probably damaging	0.99
R8048:Olfr134	UTSW	17	38175528	missense	probably benign	0.11
R8305:Olfr134	UTSW	17	38175573	missense	probably damaging	1.00
R9396:Olfr134	UTSW	17	38175530	missense	probably damaging	1.00
R9445:Olfr134	UTSW	17	38175803	missense	probably damaging	1.00
X0011:Olfr134	UTSW	17	38175851	missense	probably damaging	1.00

Posted On

2015-04-16