Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02318:Itgb4'

288125

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Itgb4

Ensembl Gene

ENSMUSG00000020758

Gene Name

integrin beta 4

Synonyms

CD104

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02318

Quality Score

Status

Chromosome

Chromosomal Location

115974709-116008412 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 115988926 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 635 (V635I)

Ref Sequence

ENSEMBL: ENSMUSP00000102069 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021107] [ENSMUST00000068981] [ENSMUST00000106458] [ENSMUST00000106460] [ENSMUST00000106461] [ENSMUST00000169928]

AlphaFold

A2A863

Predicted Effect

probably benign
Transcript: ENSMUST00000021107
AA Change: V635I

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000021107
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	712	1.32e-28	SMART
low complexity region	715	732	N/A	INTRINSIC
transmembrane domain	737	756	N/A	INTRINSIC
Calx_beta	980	1085	3.13e-35	SMART
FN3	1125	1203	3.15e-8	SMART
FN3	1218	1305	6.29e-8	SMART
low complexity region	1324	1332	N/A	INTRINSIC
FN3	1508	1589	1.79e-12	SMART
FN3	1621	1705	1.7e-13	SMART
low complexity region	1738	1751	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000068981
AA Change: V635I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000070811
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	713	7.06e-29	SMART
low complexity region	716	733	N/A	INTRINSIC
transmembrane domain	738	757	N/A	INTRINSIC
Calx_beta	981	1086	3.13e-35	SMART
FN3	1129	1207	3.15e-8	SMART
FN3	1222	1309	6.29e-8	SMART
low complexity region	1328	1336	N/A	INTRINSIC
FN3	1459	1540	1.79e-12	SMART
FN3	1572	1656	1.7e-13	SMART
low complexity region	1689	1702	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000106458
AA Change: V635I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000102066
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	713	7.06e-29	SMART
low complexity region	716	733	N/A	INTRINSIC
transmembrane domain	738	757	N/A	INTRINSIC
Calx_beta	981	1086	3.13e-35	SMART
FN3	1129	1207	3.15e-8	SMART
FN3	1222	1309	6.29e-8	SMART
low complexity region	1328	1336	N/A	INTRINSIC
low complexity region	1413	1425	N/A	INTRINSIC
FN3	1524	1605	1.79e-12	SMART
FN3	1637	1721	1.7e-13	SMART
low complexity region	1754	1767	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000106460
AA Change: V635I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000102068
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	713	7.06e-29	SMART
low complexity region	716	733	N/A	INTRINSIC
transmembrane domain	738	757	N/A	INTRINSIC
Calx_beta	981	1086	3.13e-35	SMART
FN3	1129	1207	3.15e-8	SMART
FN3	1222	1309	6.29e-8	SMART
low complexity region	1328	1336	N/A	INTRINSIC
FN3	1512	1593	1.79e-12	SMART
FN3	1625	1709	1.7e-13	SMART
low complexity region	1742	1755	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000106461
AA Change: V635I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000102069
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	713	7.06e-29	SMART
low complexity region	716	733	N/A	INTRINSIC
transmembrane domain	738	757	N/A	INTRINSIC
Calx_beta	981	1086	3.13e-35	SMART
FN3	1129	1207	3.15e-8	SMART
FN3	1222	1309	6.29e-8	SMART
low complexity region	1328	1336	N/A	INTRINSIC
low complexity region	1413	1425	N/A	INTRINSIC
FN3	1524	1605	1.79e-12	SMART
FN3	1637	1721	1.7e-13	SMART
low complexity region	1754	1767	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127523

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130286

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150129

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151691

Predicted Effect

probably benign
Transcript: ENSMUST00000169928
AA Change: V635I

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000127604
Gene: ENSMUSG00000020758
AA Change: V635I

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PSI	30	74	3.89e-1	SMART
INB	38	457	4.23e-213	SMART
VWA	130	361	8.29e-1	SMART
EGF_like	544	576	3.23e1	SMART
Integrin_B_tail	628	712	1.32e-28	SMART
low complexity region	715	732	N/A	INTRINSIC
transmembrane domain	737	756	N/A	INTRINSIC
Calx_beta	980	1085	3.13e-35	SMART
FN3	1125	1203	3.15e-8	SMART
FN3	1218	1305	6.29e-8	SMART
low complexity region	1324	1332	N/A	INTRINSIC
FN3	1508	1589	1.79e-12	SMART
FN3	1621	1705	1.7e-13	SMART
low complexity region	1738	1751	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180782

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	A	G	5: 138,563,576 (GRCm38)	F116S	probably damaging	Het
2410089E03Rik	A	G	15: 8,175,025 (GRCm38)	K96E	probably damaging	Het
4930467E23Rik	T	C	8: 19,747,799 (GRCm38)		probably null	Het
Abhd18	G	A	3: 40,930,227 (GRCm38)		probably null	Het
Akr1c6	G	T	13: 4,438,497 (GRCm38)	C34F	probably benign	Het
Ankef1	T	A	2: 136,544,775 (GRCm38)	I180N	possibly damaging	Het
Ap1b1	G	A	11: 5,019,294 (GRCm38)	V217I	probably benign	Het
Arhgap27	T	C	11: 103,333,163 (GRCm38)	Q608R	probably benign	Het
Arhgap32	A	G	9: 32,259,331 (GRCm38)	T1136A	probably benign	Het
Ascc3	T	A	10: 50,728,154 (GRCm38)	Y1323*	probably null	Het
Bsx	A	C	9: 40,874,221 (GRCm38)	Q15P	probably benign	Het
Cdh20	A	G	1: 104,954,039 (GRCm38)	I410V	probably null	Het
Col20a1	A	G	2: 181,007,159 (GRCm38)	D945G	probably damaging	Het
Cox20	A	G	1: 178,322,478 (GRCm38)		probably null	Het
Cpne9	A	G	6: 113,293,738 (GRCm38)	D305G	possibly damaging	Het
Cyp2d12	A	G	15: 82,555,243 (GRCm38)	T33A	probably benign	Het
Dvl3	A	G	16: 20,523,743 (GRCm38)	R149G	possibly damaging	Het
Dysf	A	G	6: 84,186,464 (GRCm38)	I1624V	possibly damaging	Het
Echs1	A	T	7: 140,111,710 (GRCm38)	L167Q	probably damaging	Het
Ect2	A	T	3: 27,138,719 (GRCm38)	N358K	probably benign	Het
Eml4	A	G	17: 83,441,366 (GRCm38)	I230V	probably benign	Het
Fut10	A	G	8: 31,236,258 (GRCm38)	Y347C	probably damaging	Het
Gfm2	C	A	13: 97,162,975 (GRCm38)	N401K	probably damaging	Het
Gm4788	T	A	1: 139,781,097 (GRCm38)	E24D	probably benign	Het
Gm4795	C	T	10: 45,006,639 (GRCm38)		noncoding transcript	Het
Gm5592	C	A	7: 41,286,788 (GRCm38)	T238N	probably benign	Het
Gm9892	T	C	8: 52,196,225 (GRCm38)		noncoding transcript	Het
Greb1l	G	T	18: 10,469,388 (GRCm38)	M134I	possibly damaging	Het
Grk3	A	G	5: 112,937,803 (GRCm38)	Y314H	probably damaging	Het
Hrh2	T	C	13: 54,214,650 (GRCm38)	I215T	probably damaging	Het
Ilkap	A	G	1: 91,385,238 (GRCm38)		probably null	Het
Inpp4a	T	C	1: 37,368,303 (GRCm38)	Y233H	probably damaging	Het
Lmo7	C	T	14: 101,900,066 (GRCm38)		probably benign	Het
Luc7l3	C	T	11: 94,292,993 (GRCm38)	R440Q	probably benign	Het
Mis18bp1	A	C	12: 65,158,741 (GRCm38)	I219S	probably benign	Het
Myo9b	G	A	8: 71,354,124 (GRCm38)	E1581K	probably damaging	Het
Nfs1	T	A	2: 156,124,271 (GRCm38)	Q458L	probably damaging	Het
Numb	A	T	12: 83,831,918 (GRCm38)		probably null	Het
Nxf1	G	A	19: 8,764,150 (GRCm38)		probably null	Het
Olfr134	G	T	17: 38,175,686 (GRCm38)	V201L	probably benign	Het
Olfr67	A	G	7: 103,788,268 (GRCm38)	V3A	probably benign	Het
Pde2a	A	T	7: 101,503,343 (GRCm38)	Y371F	possibly damaging	Het
Phlpp2	G	T	8: 109,939,873 (GRCm38)	L1011F	probably benign	Het
Prss27	G	T	17: 24,045,597 (GRCm38)	V245L	probably benign	Het
Rbm7	T	C	9: 48,494,111 (GRCm38)	N56S	probably damaging	Het
Rftn1	T	C	17: 50,036,970 (GRCm38)	I97V	possibly damaging	Het
Ric3	T	C	7: 109,048,080 (GRCm38)	T178A	probably damaging	Het
Rock1	A	G	18: 10,104,323 (GRCm38)		probably benign	Het
Sall2	T	C	14: 52,315,565 (GRCm38)	T56A	probably damaging	Het
Sgk1	T	C	10: 21,995,541 (GRCm38)	S60P	probably damaging	Het
Smarcad1	G	A	6: 65,073,239 (GRCm38)	A281T	probably damaging	Het
Spta1	A	G	1: 174,174,463 (GRCm38)	H53R	possibly damaging	Het
Thbs4	T	C	13: 92,763,584 (GRCm38)	D468G	probably damaging	Het
Tmem108	A	T	9: 103,499,782 (GRCm38)	V156E	probably benign	Het
Tmem206	A	G	1: 191,348,408 (GRCm38)	E275G	possibly damaging	Het
Tnfaip3	T	G	10: 19,004,467 (GRCm38)	R617S	probably benign	Het
Traf3	A	G	12: 111,237,597 (GRCm38)	M7V	probably benign	Het
Ubr3	T	A	2: 69,979,397 (GRCm38)	I1237N	probably damaging	Het
Vmn2r23	T	C	6: 123,741,836 (GRCm38)	V716A	probably benign	Het

Other mutations in Itgb4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01360:Itgb4	APN	11	115,990,940 (GRCm38)	missense	probably damaging	1.00
IGL01391:Itgb4	APN	11	115,990,920 (GRCm38)	missense	probably damaging	1.00
IGL01431:Itgb4	APN	11	116,006,457 (GRCm38)	splice site	probably benign
IGL01750:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL01752:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL01756:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL01766:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL01769:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL02188:Itgb4	APN	11	116,003,387 (GRCm38)	missense	probably benign	0.08
IGL02262:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL02293:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL02319:Itgb4	APN	11	115,988,926 (GRCm38)	missense	probably damaging	0.99
IGL02338:Itgb4	APN	11	116,007,969 (GRCm38)	missense	probably damaging	1.00
IGL02734:Itgb4	APN	11	116,005,966 (GRCm38)	missense	probably benign
IGL02879:Itgb4	APN	11	115,994,352 (GRCm38)	missense	probably benign	0.05
IGL02889:Itgb4	APN	11	115,988,905 (GRCm38)	missense	probably damaging	1.00
IGL03183:Itgb4	APN	11	115,988,724 (GRCm38)	missense	probably damaging	1.00
IGL03054:Itgb4	UTSW	11	116,000,340 (GRCm38)	nonsense	probably null
R0021:Itgb4	UTSW	11	115,979,627 (GRCm38)	missense	possibly damaging	0.95
R0092:Itgb4	UTSW	11	115,979,124 (GRCm38)	missense	probably damaging	1.00
R0305:Itgb4	UTSW	11	115,979,412 (GRCm38)	missense	probably damaging	1.00
R0408:Itgb4	UTSW	11	116,007,602 (GRCm38)	missense	probably damaging	0.99
R0465:Itgb4	UTSW	11	115,979,756 (GRCm38)	missense	probably damaging	1.00
R0499:Itgb4	UTSW	11	115,979,695 (GRCm38)	missense	probably benign	0.00
R0535:Itgb4	UTSW	11	115,991,009 (GRCm38)	missense	possibly damaging	0.86
R0571:Itgb4	UTSW	11	115,979,768 (GRCm38)	missense	possibly damaging	0.94
R0613:Itgb4	UTSW	11	115,993,342 (GRCm38)	missense	probably damaging	0.98
R0838:Itgb4	UTSW	11	115,998,162 (GRCm38)	intron	probably benign
R1381:Itgb4	UTSW	11	115,994,337 (GRCm38)	missense	probably benign	0.00
R1451:Itgb4	UTSW	11	115,990,884 (GRCm38)	missense	probably damaging	1.00
R1459:Itgb4	UTSW	11	115,979,111 (GRCm38)	missense	probably benign	0.42
R1460:Itgb4	UTSW	11	115,984,164 (GRCm38)	missense	probably damaging	0.96
R1473:Itgb4	UTSW	11	115,984,047 (GRCm38)	missense	probably benign	0.01
R1484:Itgb4	UTSW	11	115,999,799 (GRCm38)	missense	probably benign	0.01
R1593:Itgb4	UTSW	11	115,980,991 (GRCm38)	missense	probably damaging	1.00
R1623:Itgb4	UTSW	11	115,991,316 (GRCm38)	nonsense	probably null
R1633:Itgb4	UTSW	11	116,007,760 (GRCm38)	missense	probably damaging	1.00
R1642:Itgb4	UTSW	11	116,007,357 (GRCm38)	missense	probably damaging	1.00
R1669:Itgb4	UTSW	11	115,991,330 (GRCm38)	missense	probably benign	0.07
R1713:Itgb4	UTSW	11	116,003,489 (GRCm38)	missense	probably damaging	1.00
R1732:Itgb4	UTSW	11	115,988,918 (GRCm38)	missense	probably damaging	1.00
R1791:Itgb4	UTSW	11	115,988,520 (GRCm38)	missense	probably damaging	1.00
R1847:Itgb4	UTSW	11	115,983,764 (GRCm38)	missense	probably benign	0.31
R1902:Itgb4	UTSW	11	115,980,738 (GRCm38)	missense	probably damaging	0.98
R1945:Itgb4	UTSW	11	115,993,453 (GRCm38)	nonsense	probably null
R2102:Itgb4	UTSW	11	116,005,735 (GRCm38)	missense	probably benign	0.23
R2184:Itgb4	UTSW	11	115,979,624 (GRCm38)	missense	probably damaging	0.96
R2334:Itgb4	UTSW	11	115,993,435 (GRCm38)	missense	probably damaging	1.00
R2401:Itgb4	UTSW	11	116,006,563 (GRCm38)	missense	possibly damaging	0.67
R3743:Itgb4	UTSW	11	116,003,670 (GRCm38)	missense	probably damaging	1.00
R3938:Itgb4	UTSW	11	116,005,926 (GRCm38)	missense	possibly damaging	0.92
R4134:Itgb4	UTSW	11	116,006,470 (GRCm38)	missense	probably benign	0.03
R4280:Itgb4	UTSW	11	115,990,935 (GRCm38)	missense	probably damaging	1.00
R4342:Itgb4	UTSW	11	115,988,729 (GRCm38)	missense	probably benign	0.01
R4434:Itgb4	UTSW	11	115,999,814 (GRCm38)	missense	probably benign	0.10
R4505:Itgb4	UTSW	11	115,983,261 (GRCm38)	splice site	silent
R4585:Itgb4	UTSW	11	115,993,325 (GRCm38)	missense	probably damaging	1.00
R4586:Itgb4	UTSW	11	115,993,325 (GRCm38)	missense	probably damaging	1.00
R4601:Itgb4	UTSW	11	116,005,722 (GRCm38)	missense	probably damaging	1.00
R4921:Itgb4	UTSW	11	116,006,605 (GRCm38)	missense	probably benign	0.12
R4962:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5027:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5029:Itgb4	UTSW	11	115,988,591 (GRCm38)	intron	probably benign
R5084:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5085:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5124:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5125:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5150:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5175:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5176:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5179:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5207:Itgb4	UTSW	11	116,006,539 (GRCm38)	missense	probably damaging	1.00
R5263:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5264:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5334:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5337:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5344:Itgb4	UTSW	11	115,989,749 (GRCm38)	missense	probably null	0.92
R5391:Itgb4	UTSW	11	115,985,068 (GRCm38)	missense	probably benign	0.05
R5437:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5440:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5653:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5654:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5655:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5772:Itgb4	UTSW	11	115,988,432 (GRCm38)	intron	probably benign
R5812:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5813:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5814:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5863:Itgb4	UTSW	11	115,990,922 (GRCm38)	missense	probably damaging	1.00
R5864:Itgb4	UTSW	11	115,990,922 (GRCm38)	missense	probably damaging	1.00
R5865:Itgb4	UTSW	11	115,990,922 (GRCm38)	missense	probably damaging	1.00
R5951:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5954:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R5982:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6043:Itgb4	UTSW	11	115,979,386 (GRCm38)	missense	probably benign	0.30
R6133:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6134:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6135:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6169:Itgb4	UTSW	11	115,994,276 (GRCm38)	missense	probably damaging	0.98
R6172:Itgb4	UTSW	11	116,000,411 (GRCm38)	missense	probably benign	0.23
R6255:Itgb4	UTSW	11	115,998,137 (GRCm38)	missense	possibly damaging	0.83
R6258:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6259:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6260:Itgb4	UTSW	11	115,984,157 (GRCm38)	missense	probably benign	0.00
R6612:Itgb4	UTSW	11	115,984,071 (GRCm38)	missense	probably benign	0.00
R7037:Itgb4	UTSW	11	116,005,565 (GRCm38)	nonsense	probably null
R7371:Itgb4	UTSW	11	115,998,080 (GRCm38)	missense	probably benign	0.29
R7605:Itgb4	UTSW	11	116,006,476 (GRCm38)	missense	probably benign	0.01
R7659:Itgb4	UTSW	11	115,979,731 (GRCm38)	missense	probably damaging	1.00
R7759:Itgb4	UTSW	11	116,003,710 (GRCm38)	missense	possibly damaging	0.92
R7804:Itgb4	UTSW	11	116,003,684 (GRCm38)	missense	probably damaging	1.00
R7832:Itgb4	UTSW	11	116,000,261 (GRCm38)	missense	probably damaging	1.00
R7842:Itgb4	UTSW	11	115,982,705 (GRCm38)	missense	probably benign	0.18
R7923:Itgb4	UTSW	11	115,982,699 (GRCm38)	critical splice acceptor site	probably null
R8004:Itgb4	UTSW	11	115,982,705 (GRCm38)	missense	probably benign	0.00
R8143:Itgb4	UTSW	11	115,993,429 (GRCm38)	missense	probably damaging	1.00
R8427:Itgb4	UTSW	11	115,991,718 (GRCm38)	critical splice donor site	probably null
R8857:Itgb4	UTSW	11	115,981,027 (GRCm38)	missense	probably benign	0.04
R8863:Itgb4	UTSW	11	115,985,072 (GRCm38)	nonsense	probably null
R8932:Itgb4	UTSW	11	115,988,469 (GRCm38)	missense	probably benign	0.01
R9153:Itgb4	UTSW	11	115,984,053 (GRCm38)	missense	probably benign	0.00
R9207:Itgb4	UTSW	11	116,007,097 (GRCm38)	missense	probably damaging	1.00
R9239:Itgb4	UTSW	11	116,007,304 (GRCm38)	missense	probably damaging	1.00
R9267:Itgb4	UTSW	11	115,979,639 (GRCm38)	missense	probably benign
R9289:Itgb4	UTSW	11	115,994,361 (GRCm38)	missense	probably benign	0.01
R9328:Itgb4	UTSW	11	115,989,799 (GRCm38)	missense	probably benign	0.00
R9435:Itgb4	UTSW	11	116,005,029 (GRCm38)	missense	probably benign	0.01
R9450:Itgb4	UTSW	11	115,983,271 (GRCm38)	missense	probably damaging	1.00
R9649:Itgb4	UTSW	11	115,994,345 (GRCm38)	missense	possibly damaging	0.78
R9779:Itgb4	UTSW	11	115,991,659 (GRCm38)	missense	probably damaging	1.00
X0062:Itgb4	UTSW	11	115,993,452 (GRCm38)	missense	probably damaging	1.00
Z1176:Itgb4	UTSW	11	116,006,520 (GRCm38)	missense	probably damaging	1.00
Z1177:Itgb4	UTSW	11	115,998,058 (GRCm38)	missense	probably benign	0.00
Z1177:Itgb4	UTSW	11	115,986,811 (GRCm38)	missense	probably damaging	0.99

Posted On

2015-04-16