Incidental Mutation 'IGL00896:Txndc15'
ID28818
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Txndc15
Ensembl Gene ENSMUSG00000021497
Gene Namethioredoxin domain containing 15
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL00896
Quality Score
Status
Chromosome13
Chromosomal Location55714650-55726227 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 55725675 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 283 (A283T)
Ref Sequence ENSEMBL: ENSMUSP00000021959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021958] [ENSMUST00000021959] [ENSMUST00000124968]
Predicted Effect probably benign
Transcript: ENSMUST00000021958
SMART Domains Protein: ENSMUSP00000021958
Gene: ENSMUSG00000021496

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:Pterin_4a 39 132 1.5e-33 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000021959
AA Change: A283T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000021959
Gene: ENSMUSG00000021497
AA Change: A283T

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:Thioredoxin 174 278 8.6e-11 PFAM
transmembrane domain 305 324 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124968
SMART Domains Protein: ENSMUSP00000115392
Gene: ENSMUSG00000021496

DomainStartEndE-ValueType
Pfam:Pterin_4a 3 101 5.7e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223649
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 37,039,462 T4352A probably benign Het
Adam6a A G 12: 113,545,410 T468A possibly damaging Het
Ankrd35 A G 3: 96,684,276 E626G probably damaging Het
Arhgef4 A G 1: 34,811,696 Y1812C possibly damaging Het
Aurkc T C 7: 7,002,514 Y260H possibly damaging Het
Cpb1 A G 3: 20,252,029 V329A probably benign Het
Cyp2d11 G T 15: 82,391,074 probably benign Het
Dnase1 G A 16: 4,039,212 S28N probably benign Het
Evpl C A 11: 116,222,584 E1427* probably null Het
Gimap6 T C 6: 48,702,460 N214S probably benign Het
Htr1f A T 16: 64,926,106 H274Q probably benign Het
Ipo9 A T 1: 135,400,059 V538E probably damaging Het
Lmf2 T C 15: 89,353,336 K308E probably benign Het
Mog T A 17: 37,017,485 probably null Het
Myo19 T C 11: 84,909,498 V903A probably benign Het
Myt1l A G 12: 29,826,886 T179A unknown Het
Nckap1 C T 2: 80,580,953 V5M possibly damaging Het
Olfr382 T C 11: 73,516,341 N286S probably damaging Het
Olfr459 A T 6: 41,772,113 L62Q probably damaging Het
Olfr630 T C 7: 103,755,006 D193G probably damaging Het
Pcdhb5 T G 18: 37,322,785 probably null Het
Pcm1 C A 8: 41,276,123 Q711K possibly damaging Het
Pde6a A G 18: 61,220,792 D63G possibly damaging Het
Piezo1 T C 8: 122,497,870 M711V possibly damaging Het
Prrxl1 C T 14: 32,605,214 probably benign Het
Rev1 G A 1: 38,098,940 T88I probably damaging Het
Sntg1 A T 1: 8,595,410 probably null Het
Sult2a1 T A 7: 13,832,640 T137S probably benign Het
Zswim8 A G 14: 20,716,001 E785G probably damaging Het
Other mutations in Txndc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01634:Txndc15 APN 13 55721625 missense probably damaging 0.99
PIT4791001:Txndc15 UTSW 13 55721694 missense probably benign 0.39
R0309:Txndc15 UTSW 13 55724582 missense probably damaging 1.00
R0480:Txndc15 UTSW 13 55724623 missense possibly damaging 0.91
R1473:Txndc15 UTSW 13 55721574 splice site probably benign
R1856:Txndc15 UTSW 13 55718062 missense possibly damaging 0.80
R4456:Txndc15 UTSW 13 55718164 missense possibly damaging 0.82
R4945:Txndc15 UTSW 13 55718165 missense probably benign 0.01
R5159:Txndc15 UTSW 13 55717921 missense probably benign
R5376:Txndc15 UTSW 13 55718219 missense probably damaging 1.00
R5776:Txndc15 UTSW 13 55718107 missense probably benign 0.01
R7365:Txndc15 UTSW 13 55714788 missense unknown
R7392:Txndc15 UTSW 13 55721586 missense probably damaging 1.00
R7557:Txndc15 UTSW 13 55717954 missense probably benign 0.05
R7679:Txndc15 UTSW 13 55725808 missense probably damaging 0.98
Posted On2013-04-17