Incidental Mutation 'IGL00897:Ccnb1'
ID28820
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnb1
Ensembl Gene ENSMUSG00000041431
Gene Namecyclin B1
SynonymsCcnb1-rs13, Cycb-4
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL00897
Quality Score
Status
Chromosome13
Chromosomal Location100778650-100786570 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 100785911 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072119] [ENSMUST00000091295] [ENSMUST00000174038]
Predicted Effect probably benign
Transcript: ENSMUST00000072119
SMART Domains Protein: ENSMUSP00000071989
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
CYCLIN 204 288 3.88e-26 SMART
Cyclin_C 297 415 4.18e-37 SMART
CYCLIN 301 382 3.65e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091295
SMART Domains Protein: ENSMUSP00000088841
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
CYCLIN 143 227 3.88e-26 SMART
Cyclin_C 236 354 4.18e-37 SMART
CYCLIN 240 321 3.65e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128279
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134080
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147790
Predicted Effect probably benign
Transcript: ENSMUST00000174038
SMART Domains Protein: ENSMUSP00000133962
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
CYCLIN 204 288 3.88e-26 SMART
Cyclin_C 297 378 3.18e-10 SMART
CYCLIN 301 384 8.4e-13 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene is embryonic lethal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 T C 7: 120,216,125 probably benign Het
Arsi A G 18: 60,912,430 Y64C probably damaging Het
Ascc3 A T 10: 50,728,091 E1302D probably benign Het
Aspm T C 1: 139,477,407 I1344T probably damaging Het
Atp2b1 T C 10: 99,015,020 I924T possibly damaging Het
Cps1 A G 1: 67,215,564 D1304G probably benign Het
Ctsq C A 13: 61,037,725 V201F probably damaging Het
Epb41 T A 4: 132,000,197 probably null Het
Fam196b T C 11: 34,403,011 V351A probably benign Het
Fat2 T C 11: 55,289,252 E1421G probably damaging Het
Flt1 T A 5: 147,589,854 Y873F probably benign Het
Fos C T 12: 85,476,346 T344I probably damaging Het
Gm11639 G A 11: 105,100,021 D293N probably damaging Het
Gsdme A G 6: 50,229,284 probably null Het
Inpp5d A G 1: 87,712,114 T846A probably benign Het
Kdm4c T C 4: 74,373,684 M846T probably damaging Het
Lrp2 A G 2: 69,521,881 F604L possibly damaging Het
Mab21l3 C A 3: 101,823,455 R156L probably damaging Het
Mrps9 A G 1: 42,905,459 E379G probably damaging Het
Myo16 T C 8: 10,315,518 L119P probably damaging Het
Neurod2 C T 11: 98,327,769 V190M probably damaging Het
Nprl2 T G 9: 107,545,528 N371K probably benign Het
Nr1d2 A T 14: 18,214,993 C340S probably benign Het
Nsg1 A T 5: 38,144,716 V117D probably damaging Het
Olfr818 A T 10: 129,945,911 D50E possibly damaging Het
Olfr859 T G 9: 19,808,621 V101G probably damaging Het
Paqr4 T C 17: 23,737,570 D273G possibly damaging Het
Plcb4 A G 2: 135,971,798 T686A probably benign Het
Ppp1r8 G A 4: 132,827,902 A335V probably damaging Het
Slc4a2 T A 5: 24,429,559 Y65* probably null Het
Slco3a1 A T 7: 74,504,183 Y214N probably damaging Het
Tmem232 T C 17: 65,256,574 E608G possibly damaging Het
Vmn1r169 A T 7: 23,577,594 Y137F probably damaging Het
Vmn2r97 T C 17: 18,947,659 I725T probably benign Het
Vmn2r98 T A 17: 19,065,745 probably benign Het
Other mutations in Ccnb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01775:Ccnb1 APN 13 100783509 missense probably benign 0.36
IGL01874:Ccnb1 APN 13 100783493 missense probably damaging 1.00
IGL02108:Ccnb1 APN 13 100781157 critical splice donor site probably null
IGL02170:Ccnb1 APN 13 100783486 nonsense probably null
IGL02372:Ccnb1 APN 13 100781316 missense probably damaging 1.00
IGL02755:Ccnb1 APN 13 100781660 missense possibly damaging 0.89
IGL03142:Ccnb1 APN 13 100783531 missense probably damaging 1.00
R0025:Ccnb1 UTSW 13 100779781 missense probably damaging 1.00
R0499:Ccnb1 UTSW 13 100780134 critical splice acceptor site probably null
R2249:Ccnb1 UTSW 13 100781319 missense possibly damaging 0.79
R3108:Ccnb1 UTSW 13 100781624 critical splice donor site probably null
R4934:Ccnb1 UTSW 13 100781701 missense possibly damaging 0.49
R5126:Ccnb1 UTSW 13 100781775 missense possibly damaging 0.88
R5127:Ccnb1 UTSW 13 100781775 missense possibly damaging 0.88
R5180:Ccnb1 UTSW 13 100781775 missense possibly damaging 0.88
R5181:Ccnb1 UTSW 13 100781775 missense possibly damaging 0.88
R5325:Ccnb1 UTSW 13 100781775 missense possibly damaging 0.88
R7024:Ccnb1 UTSW 13 100786380 critical splice donor site probably null
R7583:Ccnb1 UTSW 13 100779754 missense probably benign 0.06
R7632:Ccnb1 UTSW 13 100781701 missense probably benign 0.32
R7833:Ccnb1 UTSW 13 100781351 missense probably damaging 1.00
Posted On2013-04-17