Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00899:Prl3d2'

28821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl3d2

Ensembl Gene

ENSMUSG00000062737

Gene Name

prolactin family 3, subfamily d, member 1

Synonyms

Plib, PL-Ib

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL00899

Quality Score

Status

Chromosome

Chromosomal Location

27305681-27311538 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27306332 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 20 (S20P)

Ref Sequence

ENSEMBL: ENSMUSP00000130458 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080755] [ENSMUST00000164964]

AlphaFold

F6R3P9

Predicted Effect

unknown
Transcript: ENSMUST00000080755
AA Change: S19P

SMART Domains

Protein: ENSMUSP00000079579
Gene: ENSMUSG00000062737
AA Change: S19P

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	224	4.5e-72	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000164964
AA Change: S20P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000130458
Gene: ENSMUSG00000062737
AA Change: S20P

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	223	3e-69	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AU018091	A	G	7: 3,208,603 (GRCm39)	I442T	probably benign	Het
Bpifb9a	T	C	2: 154,106,647 (GRCm39)		probably null	Het
Ccp110	T	A	7: 118,321,907 (GRCm39)	C521S	probably benign	Het
Chd6	A	G	2: 160,871,218 (GRCm39)		probably benign	Het
Cndp2	A	T	18: 84,695,501 (GRCm39)	D133E	probably damaging	Het
Crygs	T	C	16: 22,625,312 (GRCm39)	E43G	possibly damaging	Het
Ednra	C	T	8: 78,401,700 (GRCm39)	G197R	probably damaging	Het
Esyt1	A	G	10: 128,352,932 (GRCm39)	L656P	probably damaging	Het
Ets1	C	T	9: 32,664,104 (GRCm39)	P118L	probably damaging	Het
Fam98c	A	G	7: 28,852,278 (GRCm39)		probably benign	Het
Foxi1	G	A	11: 34,155,772 (GRCm39)	T286I	probably benign	Het
Gimap5	G	A	6: 48,730,107 (GRCm39)	A226T	possibly damaging	Het
Heatr1	C	T	13: 12,450,057 (GRCm39)	A2017V	probably benign	Het
Ikbkb	T	C	8: 23,150,463 (GRCm39)	S740G	possibly damaging	Het
Inppl1	A	T	7: 101,478,365 (GRCm39)	I617N	probably damaging	Het
Itpkb	T	C	1: 180,160,558 (GRCm39)	L228P	probably benign	Het
Kcnc4	T	A	3: 107,365,779 (GRCm39)	D143V	possibly damaging	Het
Krtdap	T	A	7: 30,489,387 (GRCm39)		probably null	Het
Lilra6	T	A	7: 3,916,056 (GRCm39)	T268S	probably damaging	Het
M6pr	A	G	6: 122,292,354 (GRCm39)	E183G	possibly damaging	Het
Muc5ac	T	A	7: 141,366,440 (GRCm39)	V2168D	possibly damaging	Het
Nbea	A	G	3: 55,550,266 (GRCm39)	S2721P	probably benign	Het
Or1j20	A	T	2: 36,760,222 (GRCm39)	I215L	probably benign	Het
Pqbp1	T	C	X: 7,762,243 (GRCm39)	N94S	probably benign	Het
Psmb2	T	C	4: 126,601,350 (GRCm39)	I151T	probably benign	Het
Rapgef6	G	T	11: 54,510,844 (GRCm39)	E107*	probably null	Het
Slc2a13	T	C	15: 91,381,602 (GRCm39)	T296A	probably benign	Het
Tcl1b4	A	G	12: 105,170,916 (GRCm39)	T55A	probably damaging	Het
Tg	T	C	15: 66,545,922 (GRCm39)		probably null	Het
Trim80	T	G	11: 115,338,491 (GRCm39)	N440K	probably benign	Het
Ttc13	C	T	8: 125,415,586 (GRCm39)		probably benign	Het
Ttc38	T	A	15: 85,728,663 (GRCm39)	I205N	possibly damaging	Het
Ufl1	T	C	4: 25,262,238 (GRCm39)	D336G	probably damaging	Het
Vmn2r74	A	T	7: 85,606,338 (GRCm39)	I336K	probably benign	Het
Zbtb26	G	T	2: 37,326,270 (GRCm39)	Y255*	probably null	Het
Zfp462	T	A	4: 55,007,732 (GRCm39)	V57E	probably damaging	Het

Other mutations in Prl3d2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01362:Prl3d2	APN	13	27,306,438 (GRCm39)	nonsense	probably null
IGL02647:Prl3d2	APN	13	27,309,999 (GRCm39)	missense	probably benign	0.06
IGL02751:Prl3d2	APN	13	27,310,014 (GRCm39)	critical splice donor site	probably null
IGL02992:Prl3d2	APN	13	27,311,266 (GRCm39)	missense	probably benign	0.00
R1116:Prl3d2	UTSW	13	27,309,985 (GRCm39)	missense	probably damaging	1.00
R1500:Prl3d2	UTSW	13	27,305,689 (GRCm39)	unclassified	probably benign
R4713:Prl3d2	UTSW	13	27,306,379 (GRCm39)	missense	probably benign
R5193:Prl3d2	UTSW	13	27,306,312 (GRCm39)	missense	possibly damaging	0.87
R6386:Prl3d2	UTSW	13	27,311,286 (GRCm39)	missense	probably damaging	0.97
R7830:Prl3d2	UTSW	13	27,310,000 (GRCm39)	missense	probably benign	0.00
R7999:Prl3d2	UTSW	13	27,307,949 (GRCm39)	missense	probably benign	0.00
R8446:Prl3d2	UTSW	13	27,307,976 (GRCm39)	missense	probably benign	0.25
R8837:Prl3d2	UTSW	13	27,307,926 (GRCm39)	missense	probably benign	0.01

Posted On

2013-04-17