Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02321:Zbtb25'

288248

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zbtb25

Ensembl Gene

ENSMUSG00000056459

Gene Name

zinc finger and BTB domain containing 25

Synonyms

Kup, 2810462M08Rik, Zfp50, Zfp-50, 2900064P18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02321

Quality Score

Status

Chromosome

Chromosomal Location

76394556-76416376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 76396907 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 105 (D105G)

Ref Sequence

ENSEMBL: ENSMUSP00000134748 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167011] [ENSMUST00000176102] [ENSMUST00000176187] [ENSMUST00000176278] [ENSMUST00000176509] [ENSMUST00000176967]

AlphaFold

G3UW50

Predicted Effect

probably damaging
Transcript: ENSMUST00000167011
AA Change: D105G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000128471
Gene: ENSMUSG00000056459
AA Change: D105G

Domain	Start	End	E-Value	Type
BTB	24	119	4.59e-15	SMART
low complexity region	213	224	N/A	INTRINSIC
ZnF_C2H2	239	261	4.4e-2	SMART
ZnF_C2H2	353	375	3.63e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000176102
AA Change: D105G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000135853
Gene: ENSMUSG00000056459
AA Change: D105G

Domain	Start	End	E-Value	Type
BTB	24	119	4.59e-15	SMART
low complexity region	213	224	N/A	INTRINSIC
ZnF_C2H2	239	261	4.4e-2	SMART
ZnF_C2H2	353	375	3.63e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176187
AA Change: D105G

PolyPhen 2 Score 0.188 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000135458
Gene: ENSMUSG00000056459
AA Change: D105G

Domain	Start	End	E-Value	Type
BTB	24	119	4.59e-15	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000176278
AA Change: D105G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000134748
Gene: ENSMUSG00000056459
AA Change: D105G

Domain	Start	End	E-Value	Type
BTB	24	119	4.59e-15	SMART
low complexity region	213	224	N/A	INTRINSIC
ZnF_C2H2	239	261	4.4e-2	SMART
ZnF_C2H2	353	375	3.63e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176509

SMART Domains

Protein: ENSMUSP00000135817
Gene: ENSMUSG00000056459

Domain	Start	End	E-Value	Type
Pfam:BTB	14	65	1e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176967

SMART Domains

Protein: ENSMUSP00000135434
Gene: ENSMUSG00000056459

Domain	Start	End	E-Value	Type
BTB	24	99	1.06e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220077

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsf3	C	T	8: 123,506,853 (GRCm39)	R49C	possibly damaging	Het
Alg2	T	C	4: 47,474,249 (GRCm39)	Y13C	probably benign	Het
Apoa4	A	G	9: 46,154,218 (GRCm39)	D273G	probably damaging	Het
Axl	C	T	7: 25,458,194 (GRCm39)	V854I	probably damaging	Het
Bicral	A	G	17: 47,122,873 (GRCm39)	S673P	probably benign	Het
Camkk2	A	G	5: 122,902,190 (GRCm39)	S40P	probably damaging	Het
Ccdc39	A	G	3: 33,871,107 (GRCm39)		probably benign	Het
Ccdc87	A	G	19: 4,891,059 (GRCm39)	E517G	probably damaging	Het
Cd22	A	G	7: 30,569,308 (GRCm39)	S603P	probably damaging	Het
Cdk5rap3	A	T	11: 96,804,291 (GRCm39)	C21S	probably damaging	Het
Chml	G	A	1: 175,519,900 (GRCm39)	P68L	possibly damaging	Het
Cplane1	A	G	15: 8,246,056 (GRCm39)	E1476G	probably benign	Het
Cstdc6	A	G	16: 36,143,388 (GRCm39)		probably benign	Het
Ephb3	T	C	16: 21,033,139 (GRCm39)	V41A	probably damaging	Het
Gm4781	T	A	10: 100,232,752 (GRCm39)		noncoding transcript	Het
Hip1r	A	T	5: 124,137,953 (GRCm39)	I760F	probably damaging	Het
Hyal5	T	C	6: 24,891,614 (GRCm39)	L476P	probably benign	Het
Isyna1	A	G	8: 71,048,920 (GRCm39)	N333S	probably damaging	Het
Kcnmb1	A	T	11: 33,920,091 (GRCm39)		probably benign	Het
Mark4	T	C	7: 19,160,314 (GRCm39)	T649A	probably benign	Het
Mgat1	T	C	11: 49,152,536 (GRCm39)	F340L	probably benign	Het
Mical1	G	A	10: 41,362,660 (GRCm39)	E932K	possibly damaging	Het
Mmaa	T	G	8: 80,000,759 (GRCm39)	Y233S	probably damaging	Het
Ntsr1	G	T	2: 180,180,627 (GRCm39)		probably null	Het
Or2o1	T	G	11: 49,051,602 (GRCm39)	Y254D	probably damaging	Het
Orm2	T	C	4: 63,281,229 (GRCm39)	Y56H	probably damaging	Het
Pex26	C	T	6: 121,170,468 (GRCm39)		probably benign	Het
Pik3r4	C	T	9: 105,521,677 (GRCm39)	A81V	probably benign	Het
Pramel32	A	G	4: 88,548,340 (GRCm39)	S22P	probably benign	Het
Prr14l	G	T	5: 32,985,151 (GRCm39)	T1448K	probably benign	Het
Ralgapa2	A	T	2: 146,254,736 (GRCm39)	Y799*	probably null	Het
Ryr1	A	C	7: 28,778,121 (GRCm39)	L2132R	probably damaging	Het
Sec23b	T	C	2: 144,421,325 (GRCm39)		probably null	Het
Sirt5	C	T	13: 43,533,164 (GRCm39)	T164I	probably damaging	Het
Slc9c1	T	C	16: 45,376,977 (GRCm39)	V429A	probably benign	Het
Spen	T	C	4: 141,244,441 (GRCm39)	D198G	unknown	Het
Syne2	A	G	12: 75,965,773 (GRCm39)	N832D	possibly damaging	Het
Traf7	C	A	17: 24,732,020 (GRCm39)	C193F	possibly damaging	Het
Vmn1r191	T	A	13: 22,363,068 (GRCm39)	R229*	probably null	Het
Vps53	C	T	11: 75,939,364 (GRCm39)	D680N	possibly damaging	Het
Wbp1l	G	T	19: 46,642,749 (GRCm39)	G234V	probably benign	Het
Wdfy3	A	T	5: 102,070,475 (GRCm39)	S1098T	probably damaging	Het
Yod1	T	A	1: 130,646,688 (GRCm39)	D188E	probably damaging	Het

Other mutations in Zbtb25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02993:Zbtb25	APN	12	76,396,191 (GRCm39)	missense	probably damaging	1.00
R1298:Zbtb25	UTSW	12	76,396,775 (GRCm39)	missense	probably benign	0.01
R1851:Zbtb25	UTSW	12	76,396,488 (GRCm39)	missense	probably damaging	1.00
R1918:Zbtb25	UTSW	12	76,396,075 (GRCm39)	nonsense	probably null
R2108:Zbtb25	UTSW	12	76,396,880 (GRCm39)	missense	probably benign	0.29
R2209:Zbtb25	UTSW	12	76,395,903 (GRCm39)	makesense	probably null
R5400:Zbtb25	UTSW	12	76,396,476 (GRCm39)	nonsense	probably null
R5579:Zbtb25	UTSW	12	76,395,938 (GRCm39)	missense	possibly damaging	0.94
R7570:Zbtb25	UTSW	12	76,416,366 (GRCm39)	unclassified	probably benign
R8086:Zbtb25	UTSW	12	76,395,923 (GRCm39)	missense	probably benign	0.27
R8910:Zbtb25	UTSW	12	76,395,908 (GRCm39)	missense	probably damaging	1.00
R8965:Zbtb25	UTSW	12	76,396,577 (GRCm39)	missense	probably benign	0.04
U24488:Zbtb25	UTSW	12	76,396,014 (GRCm39)	missense	probably benign	0.05
Z1176:Zbtb25	UTSW	12	76,396,139 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16