Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02322:Slc35g1'

288272

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35g1

Ensembl Gene

ENSMUSG00000044026

Gene Name

solute carrier family 35, member G1

Synonyms

Tmem20, D330039I19Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02322

Quality Score

Status

Chromosome

Chromosomal Location

38384428-38394055 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 38389013 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 107 (R107*)

Ref Sequence

ENSEMBL: ENSMUSP00000061282 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054098]

AlphaFold

Q8BY79

Predicted Effect

probably null
Transcript: ENSMUST00000054098
AA Change: R107*

SMART Domains

Protein: ENSMUSP00000061282
Gene: ENSMUSG00000044026
AA Change: R107*

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
Pfam:EamA	72	205	2.3e-20	PFAM
Pfam:SLC35F	72	280	3.9e-7	PFAM
Pfam:EamA	225	360	3.3e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acd	G	A	8: 106,425,268 (GRCm39)	A355V	probably benign	Het
Adam9	A	G	8: 25,445,990 (GRCm39)	V801A	probably damaging	Het
Ankrd36	T	A	11: 5,564,619 (GRCm39)	V479D	possibly damaging	Het
Arid5a	C	T	1: 36,358,497 (GRCm39)	P423L	probably benign	Het
Atp13a4	T	C	16: 29,258,920 (GRCm39)	I650V	probably benign	Het
B4gat1	C	A	19: 5,089,155 (GRCm39)	P51T	possibly damaging	Het
Caskin2	G	A	11: 115,695,303 (GRCm39)	T310M	probably damaging	Het
Ccdc121rt1	A	G	1: 181,337,999 (GRCm39)	S318P	possibly damaging	Het
Ccdc159	G	T	9: 21,840,669 (GRCm39)	V79L	possibly damaging	Het
Ccser2	A	T	14: 36,631,086 (GRCm39)	V18E	probably damaging	Het
Cct8l1	T	C	5: 25,722,581 (GRCm39)	V432A	probably benign	Het
Cdh11	A	T	8: 103,374,151 (GRCm39)	F529Y	probably benign	Het
Cep250	A	G	2: 155,832,248 (GRCm39)	E1370G	probably damaging	Het
Col22a1	C	A	15: 71,694,502 (GRCm39)	G717C	unknown	Het
Csmd2	T	C	4: 128,357,520 (GRCm39)		probably benign	Het
Ctrb1	A	C	8: 112,415,951 (GRCm39)		probably null	Het
Cyp2b19	T	C	7: 26,461,803 (GRCm39)	S208P	possibly damaging	Het
Dnmt3l	T	A	10: 77,888,572 (GRCm39)	I158N	possibly damaging	Het
Evi5l	T	C	8: 4,237,236 (GRCm39)		probably benign	Het
Fkbpl	A	G	17: 34,864,298 (GRCm39)	E22G	probably benign	Het
Flnb	T	A	14: 7,894,676 (GRCm38)	F825I	probably damaging	Het
Gjb6	A	T	14: 57,361,732 (GRCm39)	N176K	probably damaging	Het
Gpc2	G	T	5: 138,274,499 (GRCm39)		probably null	Het
H1f7	T	C	15: 98,154,757 (GRCm39)	T131A	possibly damaging	Het
Il20	C	T	1: 130,837,313 (GRCm39)	C104Y	probably damaging	Het
Mgat5	A	G	1: 127,310,722 (GRCm39)	N212S	probably benign	Het
Olfm5	C	T	7: 103,803,608 (GRCm39)	G210D	probably damaging	Het
Olig2	T	C	16: 91,023,546 (GRCm39)	S87P	probably benign	Het
Or2y15	A	G	11: 49,350,784 (GRCm39)	S93G	probably benign	Het
Or4c121	T	A	2: 89,023,806 (GRCm39)	T191S	probably damaging	Het
Osbpl7	G	T	11: 96,946,950 (GRCm39)	A418S	probably benign	Het
Otog	G	T	7: 45,950,881 (GRCm39)	R2551L	probably benign	Het
Oxt	A	T	2: 130,418,200 (GRCm39)	N24I	probably damaging	Het
Pibf1	A	G	14: 99,448,419 (GRCm39)	Y626C	probably damaging	Het
Plekhh2	A	T	17: 84,896,894 (GRCm39)	K934*	probably null	Het
Pramel14	G	A	4: 143,718,591 (GRCm39)		probably benign	Het
Prdm9	A	T	17: 15,783,110 (GRCm39)	N57K	probably damaging	Het
Rapsn	A	G	2: 90,872,251 (GRCm39)	D195G	possibly damaging	Het
Rimbp3	T	G	16: 17,029,479 (GRCm39)	F968V	probably benign	Het
Rpgrip1	A	G	14: 52,387,499 (GRCm39)	N1047S	possibly damaging	Het
Ssh2	A	C	11: 77,307,239 (GRCm39)		probably null	Het
Tiparp	C	A	3: 65,439,441 (GRCm39)	C70*	probably null	Het
Vmn2r110	A	G	17: 20,794,197 (GRCm39)	I824T	probably damaging	Het
Vmn2r78	T	C	7: 86,570,687 (GRCm39)	S402P	probably damaging	Het
Vps13c	A	G	9: 67,845,183 (GRCm39)	E2089G	probably benign	Het
Xirp2	A	T	2: 67,339,082 (GRCm39)	H441L	probably benign	Het
Zdhhc3	C	T	9: 122,929,542 (GRCm39)	G31D	probably benign	Het
Zfp330	A	G	8: 83,497,450 (GRCm39)	L64S	probably damaging	Het

Other mutations in Slc35g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01866:Slc35g1	APN	19	38,391,642 (GRCm39)	missense	probably damaging	1.00
IGL02377:Slc35g1	APN	19	38,391,678 (GRCm39)	missense	possibly damaging	0.79
R1464:Slc35g1	UTSW	19	38,391,665 (GRCm39)	missense	probably benign	0.01
R1464:Slc35g1	UTSW	19	38,391,665 (GRCm39)	missense	probably benign	0.01
R2119:Slc35g1	UTSW	19	38,391,735 (GRCm39)	missense	probably benign	0.05
R4814:Slc35g1	UTSW	19	38,391,275 (GRCm39)	missense	possibly damaging	0.58
R5229:Slc35g1	UTSW	19	38,391,080 (GRCm39)	splice site	probably null
R7176:Slc35g1	UTSW	19	38,391,771 (GRCm39)	missense	probably damaging	1.00
R7707:Slc35g1	UTSW	19	38,391,571 (GRCm39)	nonsense	probably null
R8108:Slc35g1	UTSW	19	38,391,279 (GRCm39)	missense	probably damaging	1.00
R8108:Slc35g1	UTSW	19	38,391,277 (GRCm39)	missense	probably damaging	1.00
R8253:Slc35g1	UTSW	19	38,391,237 (GRCm39)	missense	probably damaging	1.00
R9300:Slc35g1	UTSW	19	38,384,633 (GRCm39)	missense	probably benign	0.23

Posted On

2015-04-16