Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02322:Olfm5'

288302

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfm5

Ensembl Gene

ENSMUSG00000044265

Gene Name

olfactomedin 5

Synonyms

E030002O03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02322

Quality Score

Status

Chromosome

Chromosomal Location

103802220-103814023 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 103803608 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 210 (G210D)

Ref Sequence

ENSEMBL: ENSMUSP00000117893 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051137] [ENSMUST00000059121] [ENSMUST00000154555]

AlphaFold

Q8BU90

Predicted Effect

probably damaging
Transcript: ENSMUST00000051137
AA Change: G285D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052174
Gene: ENSMUSG00000044265
AA Change: G285D

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
coiled coil region	47	85	N/A	INTRINSIC
coiled coil region	157	198	N/A	INTRINSIC
OLF	211	468	3.13e-70	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000059121

SMART Domains

Protein: ENSMUSP00000056365
Gene: ENSMUSG00000051437

Domain	Start	End	E-Value	Type
UBQ	31	101	5.13e-16	SMART
Blast:STI1	199	237	8e-11	BLAST
low complexity region	339	350	N/A	INTRINSIC
low complexity region	402	419	N/A	INTRINSIC
PDB:2DNA\|A	561	610	3e-26	PDB
Blast:UBA	568	604	1e-10	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000154555
AA Change: G210D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000117893
Gene: ENSMUSG00000044265
AA Change: G210D

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
coiled coil region	47	123	N/A	INTRINSIC
OLF	136	304	3.65e-10	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acd	G	A	8: 106,425,268 (GRCm39)	A355V	probably benign	Het
Adam9	A	G	8: 25,445,990 (GRCm39)	V801A	probably damaging	Het
Ankrd36	T	A	11: 5,564,619 (GRCm39)	V479D	possibly damaging	Het
Arid5a	C	T	1: 36,358,497 (GRCm39)	P423L	probably benign	Het
Atp13a4	T	C	16: 29,258,920 (GRCm39)	I650V	probably benign	Het
B4gat1	C	A	19: 5,089,155 (GRCm39)	P51T	possibly damaging	Het
Caskin2	G	A	11: 115,695,303 (GRCm39)	T310M	probably damaging	Het
Ccdc121rt1	A	G	1: 181,337,999 (GRCm39)	S318P	possibly damaging	Het
Ccdc159	G	T	9: 21,840,669 (GRCm39)	V79L	possibly damaging	Het
Ccser2	A	T	14: 36,631,086 (GRCm39)	V18E	probably damaging	Het
Cct8l1	T	C	5: 25,722,581 (GRCm39)	V432A	probably benign	Het
Cdh11	A	T	8: 103,374,151 (GRCm39)	F529Y	probably benign	Het
Cep250	A	G	2: 155,832,248 (GRCm39)	E1370G	probably damaging	Het
Col22a1	C	A	15: 71,694,502 (GRCm39)	G717C	unknown	Het
Csmd2	T	C	4: 128,357,520 (GRCm39)		probably benign	Het
Ctrb1	A	C	8: 112,415,951 (GRCm39)		probably null	Het
Cyp2b19	T	C	7: 26,461,803 (GRCm39)	S208P	possibly damaging	Het
Dnmt3l	T	A	10: 77,888,572 (GRCm39)	I158N	possibly damaging	Het
Evi5l	T	C	8: 4,237,236 (GRCm39)		probably benign	Het
Fkbpl	A	G	17: 34,864,298 (GRCm39)	E22G	probably benign	Het
Flnb	T	A	14: 7,894,676 (GRCm38)	F825I	probably damaging	Het
Gjb6	A	T	14: 57,361,732 (GRCm39)	N176K	probably damaging	Het
Gpc2	G	T	5: 138,274,499 (GRCm39)		probably null	Het
H1f7	T	C	15: 98,154,757 (GRCm39)	T131A	possibly damaging	Het
Il20	C	T	1: 130,837,313 (GRCm39)	C104Y	probably damaging	Het
Mgat5	A	G	1: 127,310,722 (GRCm39)	N212S	probably benign	Het
Olig2	T	C	16: 91,023,546 (GRCm39)	S87P	probably benign	Het
Or2y15	A	G	11: 49,350,784 (GRCm39)	S93G	probably benign	Het
Or4c121	T	A	2: 89,023,806 (GRCm39)	T191S	probably damaging	Het
Osbpl7	G	T	11: 96,946,950 (GRCm39)	A418S	probably benign	Het
Otog	G	T	7: 45,950,881 (GRCm39)	R2551L	probably benign	Het
Oxt	A	T	2: 130,418,200 (GRCm39)	N24I	probably damaging	Het
Pibf1	A	G	14: 99,448,419 (GRCm39)	Y626C	probably damaging	Het
Plekhh2	A	T	17: 84,896,894 (GRCm39)	K934*	probably null	Het
Pramel14	G	A	4: 143,718,591 (GRCm39)		probably benign	Het
Prdm9	A	T	17: 15,783,110 (GRCm39)	N57K	probably damaging	Het
Rapsn	A	G	2: 90,872,251 (GRCm39)	D195G	possibly damaging	Het
Rimbp3	T	G	16: 17,029,479 (GRCm39)	F968V	probably benign	Het
Rpgrip1	A	G	14: 52,387,499 (GRCm39)	N1047S	possibly damaging	Het
Slc35g1	C	T	19: 38,389,013 (GRCm39)	R107*	probably null	Het
Ssh2	A	C	11: 77,307,239 (GRCm39)		probably null	Het
Tiparp	C	A	3: 65,439,441 (GRCm39)	C70*	probably null	Het
Vmn2r110	A	G	17: 20,794,197 (GRCm39)	I824T	probably damaging	Het
Vmn2r78	T	C	7: 86,570,687 (GRCm39)	S402P	probably damaging	Het
Vps13c	A	G	9: 67,845,183 (GRCm39)	E2089G	probably benign	Het
Xirp2	A	T	2: 67,339,082 (GRCm39)	H441L	probably benign	Het
Zdhhc3	C	T	9: 122,929,542 (GRCm39)	G31D	probably benign	Het
Zfp330	A	G	8: 83,497,450 (GRCm39)	L64S	probably damaging	Het

Other mutations in Olfm5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01843:Olfm5	APN	7	103,809,951 (GRCm39)	missense	possibly damaging	0.77
IGL02097:Olfm5	APN	7	103,803,438 (GRCm39)	missense	probably benign	0.20
IGL02324:Olfm5	APN	7	103,803,302 (GRCm39)	splice site	probably null
IGL02702:Olfm5	APN	7	103,803,564 (GRCm39)	missense	probably damaging	1.00
R0128:Olfm5	UTSW	7	103,810,133 (GRCm39)	missense	probably benign
R0400:Olfm5	UTSW	7	103,803,386 (GRCm39)	missense	probably damaging	1.00
R0600:Olfm5	UTSW	7	103,803,076 (GRCm39)	nonsense	probably null
R0610:Olfm5	UTSW	7	103,803,652 (GRCm39)	nonsense	probably null
R0699:Olfm5	UTSW	7	103,803,326 (GRCm39)	missense	probably damaging	1.00
R1960:Olfm5	UTSW	7	103,809,619 (GRCm39)	missense	possibly damaging	0.85
R1978:Olfm5	UTSW	7	103,813,948 (GRCm39)	missense	unknown
R2391:Olfm5	UTSW	7	103,810,041 (GRCm39)	missense	probably benign	0.00
R3774:Olfm5	UTSW	7	103,811,056 (GRCm39)	missense	possibly damaging	0.67
R4632:Olfm5	UTSW	7	103,810,100 (GRCm39)	missense	probably benign	0.00
R4770:Olfm5	UTSW	7	103,809,685 (GRCm39)	missense	probably benign	0.04
R4838:Olfm5	UTSW	7	103,803,572 (GRCm39)	missense	probably damaging	1.00
R5274:Olfm5	UTSW	7	103,809,190 (GRCm39)	missense	probably damaging	1.00
R5455:Olfm5	UTSW	7	103,803,669 (GRCm39)	missense	probably damaging	0.99
R5930:Olfm5	UTSW	7	103,803,362 (GRCm39)	missense	probably damaging	1.00
R6416:Olfm5	UTSW	7	103,803,260 (GRCm39)	missense	probably damaging	1.00
R7126:Olfm5	UTSW	7	103,809,187 (GRCm39)	missense	probably damaging	1.00
R7535:Olfm5	UTSW	7	103,803,444 (GRCm39)	missense	possibly damaging	0.92
R7682:Olfm5	UTSW	7	103,810,979 (GRCm39)	missense	probably null	0.49
R7835:Olfm5	UTSW	7	103,803,652 (GRCm39)	nonsense	probably null
R8308:Olfm5	UTSW	7	103,803,606 (GRCm39)	missense	probably damaging	1.00
R8531:Olfm5	UTSW	7	103,803,029 (GRCm39)	missense	probably benign	0.00
R9035:Olfm5	UTSW	7	103,803,099 (GRCm39)	missense	probably damaging	1.00
R9072:Olfm5	UTSW	7	103,802,984 (GRCm39)	missense	probably benign
R9185:Olfm5	UTSW	7	103,810,095 (GRCm39)	nonsense	probably null
X0011:Olfm5	UTSW	7	103,803,153 (GRCm39)	missense	possibly damaging	0.91
Z1088:Olfm5	UTSW	7	103,803,357 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16