Incidental Mutation 'IGL02323:Trim12c'
ID 288314
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim12c
Ensembl Gene ENSMUSG00000057143
Gene Name tripartite motif-containing 12C
Synonyms Trim12-2, 9230105E10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL02323
Quality Score
Status
Chromosome 7
Chromosomal Location 103987961-104002569 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 103997473 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 28 (A28T)
Ref Sequence ENSEMBL: ENSMUSP00000116775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059037] [ENSMUST00000130139]
AlphaFold D3Z3L3
Predicted Effect probably benign
Transcript: ENSMUST00000059037
AA Change: A28T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000060100
Gene: ENSMUSG00000057143
AA Change: A28T

DomainStartEndE-ValueType
RING 15 58 5.51e-7 SMART
BBOX 91 132 4.83e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Pfam:SPRY 351 493 8.7e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130139
AA Change: A28T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000116775
Gene: ENSMUSG00000057143
AA Change: A28T

DomainStartEndE-ValueType
RING 15 58 5.51e-7 SMART
BBOX 91 132 4.83e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ache A G 5: 137,289,326 (GRCm39) E344G probably damaging Het
Actrt2 T C 4: 154,751,255 (GRCm39) T294A probably benign Het
Afg1l C A 10: 42,330,506 (GRCm39) E54* probably null Het
Ahi1 T C 10: 20,847,933 (GRCm39) I447T probably damaging Het
Akap6 T C 12: 53,187,212 (GRCm39) I1542T probably benign Het
Ankrd34c A C 9: 89,612,033 (GRCm39) S103A possibly damaging Het
Apc C T 18: 34,448,863 (GRCm39) Q1886* probably null Het
Bcas3 A G 11: 85,386,671 (GRCm39) T148A probably damaging Het
Bud13 A G 9: 46,194,350 (GRCm39) T8A probably benign Het
Casr A T 16: 36,330,072 (GRCm39) Y421N probably damaging Het
Ccdc121rt2 A G 5: 112,597,600 (GRCm39) Y49C probably benign Het
Clasp2 T C 9: 113,697,794 (GRCm39) probably benign Het
Clca4b T C 3: 144,619,082 (GRCm39) T686A probably benign Het
Cntln T A 4: 84,968,026 (GRCm39) H748Q probably benign Het
Dmtf1 A T 5: 9,170,056 (GRCm39) D683E possibly damaging Het
Dnmt3l A G 10: 77,899,152 (GRCm39) K117R probably damaging Het
Eif2a T C 3: 58,456,024 (GRCm39) M341T possibly damaging Het
Epg5 T A 18: 78,056,047 (GRCm39) Y1740* probably null Het
Fam149b C T 14: 20,413,369 (GRCm39) T157I possibly damaging Het
Fam89b A G 19: 5,778,899 (GRCm39) probably null Het
Fbxo3 T A 2: 103,878,296 (GRCm39) N232K probably benign Het
Gnl3 A C 14: 30,739,359 (GRCm39) H16Q probably damaging Het
Gpld1 T G 13: 25,166,757 (GRCm39) V669G probably damaging Het
Grik3 A G 4: 125,579,783 (GRCm39) probably benign Het
Gzmg A C 14: 56,394,729 (GRCm39) Y180D probably benign Het
H2-M9 A T 17: 36,951,633 (GRCm39) Y281N probably damaging Het
Katnip T A 7: 125,442,001 (GRCm39) S637T probably benign Het
Mical1 G A 10: 41,362,660 (GRCm39) E932K possibly damaging Het
Mrs2 T A 13: 25,188,940 (GRCm39) I125F probably damaging Het
Nfam1 T A 15: 82,907,152 (GRCm39) N15I probably benign Het
Nol8 T A 13: 49,808,721 (GRCm39) probably benign Het
Obscn A G 11: 58,899,348 (GRCm39) V6483A possibly damaging Het
Or2a56 A T 6: 42,932,917 (GRCm39) I162F probably benign Het
Osbpl3 A G 6: 50,323,306 (GRCm39) probably null Het
Plaat3 G A 19: 7,552,357 (GRCm39) W24* probably null Het
Ppfibp2 A T 7: 107,337,836 (GRCm39) Q652H probably damaging Het
Rbm47 A G 5: 66,183,772 (GRCm39) V277A probably damaging Het
Robo3 G A 9: 37,333,497 (GRCm39) A716V probably benign Het
Scart1 G T 7: 139,808,572 (GRCm39) A828S probably benign Het
Semp2l1 A T 1: 32,584,785 (GRCm39) L375* probably null Het
Slc29a4 A G 5: 142,703,407 (GRCm39) E227G probably damaging Het
Slf1 T C 13: 77,199,413 (GRCm39) D656G possibly damaging Het
Sox1 A G 8: 12,446,692 (GRCm39) H111R possibly damaging Het
Spmip9 A G 6: 70,890,679 (GRCm39) probably benign Het
Svep1 G A 4: 58,070,236 (GRCm39) Q2517* probably null Het
Syndig1 G T 2: 149,741,707 (GRCm39) V98L probably benign Het
Synpo2 T C 3: 122,911,183 (GRCm39) E154G probably benign Het
Tkt G A 14: 30,292,992 (GRCm39) G490S possibly damaging Het
Tmem200a T C 10: 25,869,328 (GRCm39) N314D probably benign Het
Tnfaip8l1 A T 17: 56,479,009 (GRCm39) T100S probably damaging Het
Traf7 C A 17: 24,732,020 (GRCm39) C193F possibly damaging Het
Trpc7 C A 13: 56,931,564 (GRCm39) V595L possibly damaging Het
Ttc39c A G 18: 12,869,800 (GRCm39) R575G probably null Het
Ttn T G 2: 76,681,919 (GRCm39) probably benign Het
Ttn C T 2: 76,553,609 (GRCm39) V31003M probably damaging Het
Ugt2b37 A T 5: 87,398,423 (GRCm39) probably benign Het
Uqcrb A T 13: 67,050,874 (GRCm39) probably benign Het
Usp33 T A 3: 152,076,024 (GRCm39) W415R probably benign Het
Vmn2r110 A T 17: 20,816,399 (GRCm39) D41E probably damaging Het
Vmn2r98 A T 17: 19,286,113 (GRCm39) I204F probably damaging Het
Other mutations in Trim12c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01612:Trim12c APN 7 103,997,422 (GRCm39) missense possibly damaging 0.81
IGL01645:Trim12c APN 7 103,994,261 (GRCm39) nonsense probably null
IGL01737:Trim12c APN 7 103,997,269 (GRCm39) missense probably damaging 1.00
IGL02184:Trim12c APN 7 103,997,430 (GRCm39) missense probably benign 0.00
IGL02309:Trim12c APN 7 103,994,163 (GRCm39) missense possibly damaging 0.72
IGL02656:Trim12c APN 7 103,990,410 (GRCm39) missense probably damaging 1.00
R0127:Trim12c UTSW 7 103,990,113 (GRCm39) splice site probably null
R0554:Trim12c UTSW 7 103,994,169 (GRCm39) missense probably damaging 0.96
R1480:Trim12c UTSW 7 103,997,451 (GRCm39) missense probably damaging 1.00
R1501:Trim12c UTSW 7 103,990,095 (GRCm39) unclassified probably benign
R2058:Trim12c UTSW 7 103,997,398 (GRCm39) missense possibly damaging 0.81
R2059:Trim12c UTSW 7 103,997,398 (GRCm39) missense possibly damaging 0.81
R3838:Trim12c UTSW 7 103,990,075 (GRCm39) unclassified probably benign
R3870:Trim12c UTSW 7 103,997,544 (GRCm39) missense probably benign 0.00
R4896:Trim12c UTSW 7 103,990,155 (GRCm39) missense probably damaging 0.99
R6288:Trim12c UTSW 7 103,995,936 (GRCm39) missense probably benign 0.19
R6522:Trim12c UTSW 7 103,997,531 (GRCm39) missense probably benign 0.38
R6562:Trim12c UTSW 7 103,994,341 (GRCm39) splice site probably null
R6801:Trim12c UTSW 7 103,997,337 (GRCm39) missense probably damaging 1.00
R7016:Trim12c UTSW 7 103,997,413 (GRCm39) missense
R7811:Trim12c UTSW 7 103,990,469 (GRCm39) missense unknown
R8076:Trim12c UTSW 7 103,990,037 (GRCm39) missense unknown
R8147:Trim12c UTSW 7 103,991,165 (GRCm39) missense unknown
R8680:Trim12c UTSW 7 103,997,271 (GRCm39) missense
R9295:Trim12c UTSW 7 103,990,391 (GRCm39) missense unknown
R9296:Trim12c UTSW 7 103,994,185 (GRCm39) missense
X0062:Trim12c UTSW 7 103,995,887 (GRCm39) missense probably benign 0.13
Z1176:Trim12c UTSW 7 103,990,343 (GRCm39) missense unknown
Posted On 2015-04-16