Incidental Mutation 'IGL00910:Prl2c5'
ID28834
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl2c5
Ensembl Gene ENSMUSG00000055360
Gene Nameprolactin family 2, subfamily c, member 5
SynonymsMRP-4, PLF-4, Mrpplf4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL00910
Quality Score
Status
Chromosome13
Chromosomal Location13182715-13191923 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 13189476 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021778] [ENSMUST00000126540] [ENSMUST00000151144]
Predicted Effect probably null
Transcript: ENSMUST00000021778
SMART Domains Protein: ENSMUSP00000021778
Gene: ENSMUSG00000055360

DomainStartEndE-ValueType
Pfam:Hormone_1 16 222 2.7e-70 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000126540
SMART Domains Protein: ENSMUSP00000115024
Gene: ENSMUSG00000055360

DomainStartEndE-ValueType
Pfam:Hormone_1 19 225 1.5e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143335
Predicted Effect probably null
Transcript: ENSMUST00000151144
SMART Domains Protein: ENSMUSP00000117522
Gene: ENSMUSG00000055360

DomainStartEndE-ValueType
Pfam:Hormone_1 16 172 3.5e-51 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A G 15: 84,955,819 L109P probably damaging Het
Aacs T A 5: 125,508,708 M316K probably benign Het
Adarb2 T C 13: 8,672,433 V375A probably damaging Het
Adgra2 C A 8: 27,085,983 A13E possibly damaging Het
Ankrd34c A T 9: 89,729,026 S421T probably benign Het
Bpifa6 A T 2: 153,990,466 M298L probably benign Het
Casq2 T C 3: 102,110,231 probably benign Het
Ckap5 A G 2: 91,576,050 T762A probably benign Het
Dhx38 A G 8: 109,559,034 V389A probably benign Het
Dnah7b A T 1: 46,066,729 probably benign Het
Dnajc7 A T 11: 100,599,191 F79L possibly damaging Het
Dyrk3 A G 1: 131,136,336 I3T possibly damaging Het
Fam84a T C 12: 14,150,526 S67G probably benign Het
Fchsd2 T C 7: 101,277,626 I641T probably benign Het
Furin A G 7: 80,390,996 V698A probably benign Het
Ryr3 A T 2: 112,728,934 probably benign Het
Serpina6 G T 12: 103,651,965 probably benign Het
Slc6a2 A G 8: 92,996,100 Y575C probably damaging Het
Trim9 T C 12: 70,347,113 E19G probably damaging Het
Tsfm G T 10: 127,028,359 probably benign Het
Other mutations in Prl2c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01874:Prl2c5 APN 13 13190777 missense probably benign
IGL01878:Prl2c5 APN 13 13185817 missense probably benign 0.00
R0178:Prl2c5 UTSW 13 13191805 missense probably damaging 0.98
R0276:Prl2c5 UTSW 13 13183049 intron probably benign
R0373:Prl2c5 UTSW 13 13183024 intron probably benign
R0539:Prl2c5 UTSW 13 13189321 splice site probably null
R1037:Prl2c5 UTSW 13 13185907 nonsense probably null
R1296:Prl2c5 UTSW 13 13189424 missense probably damaging 1.00
R1458:Prl2c5 UTSW 13 13190725 missense probably benign 0.40
R1557:Prl2c5 UTSW 13 13190680 missense possibly damaging 0.52
R1850:Prl2c5 UTSW 13 13185792 missense probably benign 0.40
R1866:Prl2c5 UTSW 13 13190773 splice site probably null
R1894:Prl2c5 UTSW 13 13191678 missense probably benign 0.04
R2060:Prl2c5 UTSW 13 13190653 missense probably damaging 0.99
R2330:Prl2c5 UTSW 13 13191793 missense possibly damaging 0.67
R4755:Prl2c5 UTSW 13 13189385 missense probably benign
R5229:Prl2c5 UTSW 13 13185856 missense probably damaging 1.00
R5364:Prl2c5 UTSW 13 13183042 missense probably benign 0.01
R6307:Prl2c5 UTSW 13 13190590 missense probably benign 0.01
R6350:Prl2c5 UTSW 13 13183046 critical splice donor site probably null
R6927:Prl2c5 UTSW 13 13182918 splice site probably null
R7397:Prl2c5 UTSW 13 13191742 missense probably benign 0.01
R7965:Prl2c5 UTSW 13 13185884 missense probably benign 0.01
R8084:Prl2c5 UTSW 13 13185954 missense probably benign 0.20
RF020:Prl2c5 UTSW 13 13185912 missense probably benign 0.28
X0025:Prl2c5 UTSW 13 13191754 missense probably benign 0.03
Posted On2013-04-17