Incidental Mutation 'IGL00914:Shc3'
ID28837
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Shc3
Ensembl Gene ENSMUSG00000021448
Gene Namesrc homology 2 domain-containing transforming protein C3
SynonymsRai, ShcC, N-Shc
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL00914
Quality Score
Status
Chromosome13
Chromosomal Location51431041-51569419 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 51480227 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152080 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021898] [ENSMUST00000223543]
Predicted Effect probably benign
Transcript: ENSMUST00000021898
SMART Domains Protein: ENSMUSP00000021898
Gene: ENSMUSG00000021448

DomainStartEndE-ValueType
PTB 30 194 5.36e-41 SMART
SH2 377 456 6.38e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223543
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 T G 10: 20,984,299 probably null Het
Aipl1 T C 11: 72,031,547 D112G probably damaging Het
Casz1 G A 4: 148,929,371 E131K probably damaging Het
Chrna4 A G 2: 181,029,031 Y311H probably damaging Het
Cyp2d34 G T 15: 82,620,714 N48K probably damaging Het
Dnajc13 T A 9: 104,212,882 K696I possibly damaging Het
Fbxo30 T C 10: 11,290,539 V335A probably benign Het
Itga5 A G 15: 103,350,372 probably null Het
Morc2a G A 11: 3,668,844 probably null Het
Nek8 T C 11: 78,173,075 I35V possibly damaging Het
Olfr1453 A G 19: 13,027,591 V246A probably damaging Het
Olfr893 A G 9: 38,209,799 probably null Het
Pcyt2 A G 11: 120,614,325 probably benign Het
Sec23b T G 2: 144,566,864 S156R probably damaging Het
Sntg2 A G 12: 30,257,957 probably benign Het
Srms T A 2: 181,207,772 M280L probably benign Het
Wdr60 A G 12: 116,232,603 V508A probably damaging Het
Other mutations in Shc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00555:Shc3 APN 13 51461343 missense probably damaging 0.98
IGL01417:Shc3 APN 13 51431164 missense probably benign 0.10
IGL01536:Shc3 APN 13 51516559 missense probably damaging 1.00
Massless UTSW 13 51442973 missense possibly damaging 0.92
Singularity UTSW 13 51442820 intron probably null
R0499:Shc3 UTSW 13 51480228 splice site probably benign
R0941:Shc3 UTSW 13 51480206 missense probably benign
R1652:Shc3 UTSW 13 51472839 missense probably damaging 0.99
R1739:Shc3 UTSW 13 51482916 missense probably damaging 0.97
R1750:Shc3 UTSW 13 51449292 missense probably damaging 1.00
R1817:Shc3 UTSW 13 51472852 missense possibly damaging 0.93
R1848:Shc3 UTSW 13 51461388 missense probably damaging 1.00
R1991:Shc3 UTSW 13 51442836 missense probably benign 0.01
R2103:Shc3 UTSW 13 51442836 missense probably benign 0.01
R4426:Shc3 UTSW 13 51480094 splice site probably null
R4434:Shc3 UTSW 13 51449266 missense probably benign 0.00
R4823:Shc3 UTSW 13 51451570 missense probably benign
R4933:Shc3 UTSW 13 51442769 missense probably benign 0.03
R4998:Shc3 UTSW 13 51442820 intron probably null
R5153:Shc3 UTSW 13 51461377 missense probably damaging 1.00
R5200:Shc3 UTSW 13 51516565 missense probably damaging 1.00
R5659:Shc3 UTSW 13 51516594 missense probably damaging 1.00
R6035:Shc3 UTSW 13 51461432 missense probably damaging 1.00
R6035:Shc3 UTSW 13 51461432 missense probably damaging 1.00
R6346:Shc3 UTSW 13 51451615 missense possibly damaging 0.93
R6434:Shc3 UTSW 13 51449290 missense probably damaging 1.00
R6457:Shc3 UTSW 13 51482879 splice site probably null
R6580:Shc3 UTSW 13 51442773 missense probably benign
R6597:Shc3 UTSW 13 51442973 missense possibly damaging 0.92
R6906:Shc3 UTSW 13 51466559 missense probably damaging 0.97
R7003:Shc3 UTSW 13 51466552 missense probably benign 0.14
R7104:Shc3 UTSW 13 51431205 missense possibly damaging 0.89
R7420:Shc3 UTSW 13 51431235 missense probably benign 0.02
R7476:Shc3 UTSW 13 51448006 missense probably benign
Z1177:Shc3 UTSW 13 51442928 missense probably benign 0.00
Posted On2013-04-17