Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00914:Shc3'

28837

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Shc3

Ensembl Gene

ENSMUSG00000021448

Gene Name

src homology 2 domain-containing transforming protein C3

Synonyms

ShcC, Rai, N-Shc

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL00914

Quality Score

Status

Chromosome

Chromosomal Location

51585077-51723523 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 51634263 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152080 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021898] [ENSMUST00000223543]

AlphaFold

Q61120

Predicted Effect

probably benign
Transcript: ENSMUST00000021898

SMART Domains

Protein: ENSMUSP00000021898
Gene: ENSMUSG00000021448

Domain	Start	End	E-Value	Type
PTB	30	194	5.36e-41	SMART
SH2	377	456	6.38e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000223543

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahi1	T	G	10: 20,860,198 (GRCm39)		probably null	Het
Aipl1	T	C	11: 71,922,373 (GRCm39)	D112G	probably damaging	Het
Casz1	G	A	4: 149,013,828 (GRCm39)	E131K	probably damaging	Het
Chrna4	A	G	2: 180,670,824 (GRCm39)	Y311H	probably damaging	Het
Cyp2d34	G	T	15: 82,504,915 (GRCm39)	N48K	probably damaging	Het
Dnajc13	T	A	9: 104,090,081 (GRCm39)	K696I	possibly damaging	Het
Dync2i1	A	G	12: 116,196,223 (GRCm39)	V508A	probably damaging	Het
Fbxo30	T	C	10: 11,166,283 (GRCm39)	V335A	probably benign	Het
Itga5	A	G	15: 103,258,799 (GRCm39)		probably null	Het
Morc2a	G	A	11: 3,618,844 (GRCm39)		probably null	Het
Nek8	T	C	11: 78,063,901 (GRCm39)	I35V	possibly damaging	Het
Or5b101	A	G	19: 13,004,955 (GRCm39)	V246A	probably damaging	Het
Or8c15	A	G	9: 38,121,095 (GRCm39)		probably null	Het
Pcyt2	A	G	11: 120,505,151 (GRCm39)		probably benign	Het
Sec23b	T	G	2: 144,408,784 (GRCm39)	S156R	probably damaging	Het
Sntg2	A	G	12: 30,307,956 (GRCm39)		probably benign	Het
Srms	T	A	2: 180,849,565 (GRCm39)	M280L	probably benign	Het

Other mutations in Shc3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00555:Shc3	APN	13	51,615,379 (GRCm39)	missense	probably damaging	0.98
IGL01417:Shc3	APN	13	51,585,200 (GRCm39)	missense	probably benign	0.10
IGL01536:Shc3	APN	13	51,670,595 (GRCm39)	missense	probably damaging	1.00
Massless	UTSW	13	51,597,009 (GRCm39)	missense	possibly damaging	0.92
Singularity	UTSW	13	51,596,856 (GRCm39)	splice site	probably null
R0499:Shc3	UTSW	13	51,634,264 (GRCm39)	splice site	probably benign
R0941:Shc3	UTSW	13	51,634,242 (GRCm39)	missense	probably benign
R1652:Shc3	UTSW	13	51,626,875 (GRCm39)	missense	probably damaging	0.99
R1739:Shc3	UTSW	13	51,636,952 (GRCm39)	missense	probably damaging	0.97
R1750:Shc3	UTSW	13	51,603,328 (GRCm39)	missense	probably damaging	1.00
R1817:Shc3	UTSW	13	51,626,888 (GRCm39)	missense	possibly damaging	0.93
R1848:Shc3	UTSW	13	51,615,424 (GRCm39)	missense	probably damaging	1.00
R1991:Shc3	UTSW	13	51,596,872 (GRCm39)	missense	probably benign	0.01
R2103:Shc3	UTSW	13	51,596,872 (GRCm39)	missense	probably benign	0.01
R4426:Shc3	UTSW	13	51,634,130 (GRCm39)	splice site	probably null
R4434:Shc3	UTSW	13	51,603,302 (GRCm39)	missense	probably benign	0.00
R4823:Shc3	UTSW	13	51,605,606 (GRCm39)	missense	probably benign
R4933:Shc3	UTSW	13	51,596,805 (GRCm39)	missense	probably benign	0.03
R4998:Shc3	UTSW	13	51,596,856 (GRCm39)	splice site	probably null
R5153:Shc3	UTSW	13	51,615,413 (GRCm39)	missense	probably damaging	1.00
R5200:Shc3	UTSW	13	51,670,601 (GRCm39)	missense	probably damaging	1.00
R5659:Shc3	UTSW	13	51,670,630 (GRCm39)	missense	probably damaging	1.00
R6035:Shc3	UTSW	13	51,615,468 (GRCm39)	missense	probably damaging	1.00
R6035:Shc3	UTSW	13	51,615,468 (GRCm39)	missense	probably damaging	1.00
R6346:Shc3	UTSW	13	51,605,651 (GRCm39)	missense	possibly damaging	0.93
R6434:Shc3	UTSW	13	51,603,326 (GRCm39)	missense	probably damaging	1.00
R6457:Shc3	UTSW	13	51,636,915 (GRCm39)	splice site	probably null
R6580:Shc3	UTSW	13	51,596,809 (GRCm39)	missense	probably benign
R6597:Shc3	UTSW	13	51,597,009 (GRCm39)	missense	possibly damaging	0.92
R6906:Shc3	UTSW	13	51,620,595 (GRCm39)	missense	probably damaging	0.97
R7003:Shc3	UTSW	13	51,620,588 (GRCm39)	missense	probably benign	0.14
R7104:Shc3	UTSW	13	51,585,241 (GRCm39)	missense	possibly damaging	0.89
R7420:Shc3	UTSW	13	51,585,271 (GRCm39)	missense	probably benign	0.02
R7476:Shc3	UTSW	13	51,602,042 (GRCm39)	missense	probably benign
R8312:Shc3	UTSW	13	51,596,754 (GRCm39)	missense	probably damaging	1.00
R8774:Shc3	UTSW	13	51,615,475 (GRCm39)	missense	probably damaging	1.00
R8774-TAIL:Shc3	UTSW	13	51,615,475 (GRCm39)	missense	probably damaging	1.00
R8850:Shc3	UTSW	13	51,634,248 (GRCm39)	missense	probably benign	0.04
Z1177:Shc3	UTSW	13	51,596,964 (GRCm39)	missense	probably benign	0.00

Posted On

2013-04-17