Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02324:Dpp10'

288376

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dpp10

Ensembl Gene

ENSMUSG00000036815

Gene Name

dipeptidylpeptidase 10

Synonyms

6430601K09Rik, DPRP3

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02324

Quality Score

Status

Chromosome

Chromosomal Location

123321471-124045559 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123367802 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 539 (T539S)

Ref Sequence

ENSEMBL: ENSMUSP00000108225 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000112603] [ENSMUST00000112606]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000112603
AA Change: T528S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000108222
Gene: ENSMUSG00000036815
AA Change: T528S

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
Pfam:DPPIV_N	83	450	4.9e-118	PFAM
Pfam:Peptidase_S9	530	734	6.4e-47	PFAM
Pfam:DLH	556	711	1.4e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000112606
AA Change: T539S

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000108225
Gene: ENSMUSG00000036815
AA Change: T539S

Domain	Start	End	E-Value	Type
transmembrane domain	38	60	N/A	INTRINSIC
low complexity region	64	79	N/A	INTRINSIC
Pfam:DPPIV_N	137	504	4.4e-115	PFAM
Pfam:Peptidase_S9	584	788	8.6e-48	PFAM
Pfam:DLH	604	774	1.1e-7	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193624

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194472

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	T	A	3: 151,497,874	C124S	probably damaging	Het
Aldh1a7	T	C	19: 20,727,004	N42S	probably damaging	Het
Arhgef1	T	C	7: 24,923,815	L667P	probably damaging	Het
C1qb	C	A	4: 136,880,500	R184L	possibly damaging	Het
Cacna1s	A	G	1: 136,075,176		probably benign	Het
Cdk20	A	G	13: 64,437,920	E244G	probably benign	Het
Copg2	C	A	6: 30,863,534		probably null	Het
Cyp2d40	A	T	15: 82,760,948		probably benign	Het
Cyp2j6	A	G	4: 96,525,933	I365T	probably damaging	Het
Dhx29	A	G	13: 112,927,808	K6E	probably damaging	Het
Ehbp1	A	T	11: 22,096,048	I542K	probably damaging	Het
Fat1	A	G	8: 45,040,556	Y3913C	probably damaging	Het
Flt4	C	T	11: 49,645,995	T1264I	probably benign	Het
Fmnl1	A	G	11: 103,179,538	D51G	probably damaging	Het
Gm17093	A	G	14: 44,518,350	T25A	unknown	Het
Gpatch2	A	G	1: 187,225,739	E97G	probably damaging	Het
Hcn1	T	C	13: 117,902,886	L446P	unknown	Het
Hpse2	A	T	19: 42,931,599	L354I	probably damaging	Het
Hspa4	A	G	11: 53,300,058		probably null	Het
Krtap16-1	C	T	11: 99,986,303	V92M	probably damaging	Het
Med23	A	T	10: 24,897,341	Q281L	probably damaging	Het
Megf8	T	C	7: 25,340,448	S963P	probably benign	Het
Mical1	G	A	10: 41,486,664	E932K	possibly damaging	Het
Mycbp2	A	G	14: 103,242,207	S1217P	probably damaging	Het
Myocd	C	A	11: 65,178,658	L785F	probably benign	Het
Nell2	T	C	15: 95,229,101	T798A	probably damaging	Het
Nfat5	T	C	8: 107,366,176		probably benign	Het
Olfm5	T	C	7: 104,154,095		probably null	Het
Olfr385	A	G	11: 73,589,255	V161A	probably benign	Het
P2ry1	A	T	3: 61,003,778	N113Y	possibly damaging	Het
Pan3	A	G	5: 147,530,123		probably null	Het
Pappa	A	G	4: 65,196,808	R714G	probably damaging	Het
Plcd1	A	G	9: 119,072,642	F579L	probably damaging	Het
Ptprb	T	C	10: 116,319,333	V664A	probably benign	Het
Slc27a5	T	A	7: 12,997,560	Q168L	probably benign	Het
Spag8	T	C	4: 43,651,781	E395G	probably damaging	Het
Stfa2l1	T	C	16: 36,161,768	Y70H	probably damaging	Het
Taf2	T	C	15: 55,028,376	N1017S	probably benign	Het
Tnfrsf25	C	A	4: 152,119,322	Q296K	probably damaging	Het
Trpm3	T	A	19: 22,698,779	I103N	probably benign	Het

Other mutations in Dpp10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01592:Dpp10	APN	1	123334370	missense	probably damaging	1.00
IGL01618:Dpp10	APN	1	123367867	missense	probably benign
IGL02101:Dpp10	APN	1	123411826	missense	probably damaging	1.00
IGL02284:Dpp10	APN	1	124045366	splice site	probably benign
IGL02391:Dpp10	APN	1	123650358	missense	probably damaging	0.98
IGL02458:Dpp10	APN	1	123341689	missense	probably benign	0.01
IGL02469:Dpp10	APN	1	123411803	missense	probably benign	0.01
IGL02501:Dpp10	APN	1	123686270	missense	possibly damaging	0.93
IGL02522:Dpp10	APN	1	123423652	missense	probably benign	0.24
IGL02672:Dpp10	APN	1	123376647	missense	probably benign	0.45
IGL03034:Dpp10	APN	1	123341619	missense	probably damaging	1.00
PIT1430001:Dpp10	UTSW	1	123341182	splice site	probably benign
R0104:Dpp10	UTSW	1	123367843	missense	probably benign	0.00
R0114:Dpp10	UTSW	1	123486092	missense	probably benign	0.07
R0242:Dpp10	UTSW	1	123398546	missense	possibly damaging	0.56
R0242:Dpp10	UTSW	1	123398546	missense	possibly damaging	0.56
R0682:Dpp10	UTSW	1	123905125	missense	probably damaging	0.98
R0815:Dpp10	UTSW	1	123432929	critical splice donor site	probably null
R1549:Dpp10	UTSW	1	123341380	critical splice acceptor site	probably null
R1742:Dpp10	UTSW	1	123445206	missense	probably damaging	1.00
R1859:Dpp10	UTSW	1	123353604	missense	possibly damaging	0.47
R1991:Dpp10	UTSW	1	123905106	missense	probably null	1.00
R1992:Dpp10	UTSW	1	123905106	missense	probably null	1.00
R2079:Dpp10	UTSW	1	123432992	missense	probably damaging	1.00
R2882:Dpp10	UTSW	1	123445203	missense	probably damaging	1.00
R2974:Dpp10	UTSW	1	123411705	splice site	probably benign
R3827:Dpp10	UTSW	1	123411790	missense	possibly damaging	0.56
R3852:Dpp10	UTSW	1	123485924	nonsense	probably null
R3876:Dpp10	UTSW	1	123353487	missense	probably damaging	0.98
R3899:Dpp10	UTSW	1	123353557	missense	probably damaging	1.00
R4735:Dpp10	UTSW	1	123398627	missense	probably benign	0.15
R4922:Dpp10	UTSW	1	123378153	missense	probably benign	0.44
R5457:Dpp10	UTSW	1	123411810	missense	possibly damaging	0.51
R5599:Dpp10	UTSW	1	123905076	missense	probably damaging	0.99
R5913:Dpp10	UTSW	1	123384289	missense	probably damaging	1.00
R5979:Dpp10	UTSW	1	123384283	critical splice donor site	probably null
R6378:Dpp10	UTSW	1	123411739	missense	probably damaging	1.00
R6429:Dpp10	UTSW	1	123367601	missense	possibly damaging	0.72
R6505:Dpp10	UTSW	1	123336851	missense	probably damaging	0.99
R6776:Dpp10	UTSW	1	123367656	nonsense	probably null
R6894:Dpp10	UTSW	1	123336864	missense	probably damaging	1.00
R6951:Dpp10	UTSW	1	123341650	missense	possibly damaging	0.93
R7182:Dpp10	UTSW	1	123341151	missense	probably benign	0.15
R7246:Dpp10	UTSW	1	123334377	missense	probably damaging	1.00
R7297:Dpp10	UTSW	1	123353428	nonsense	probably null
R7375:Dpp10	UTSW	1	123367795	missense	probably benign
R7387:Dpp10	UTSW	1	123341140	missense	probably benign	0.01
R7661:Dpp10	UTSW	1	123384952	missense	probably damaging	1.00
R8065:Dpp10	UTSW	1	123352660	missense	probably benign
R8067:Dpp10	UTSW	1	123352660	missense	probably benign
R8260:Dpp10	UTSW	1	123686295	missense	probably benign
R8324:Dpp10	UTSW	1	123854172	missense	probably benign	0.02
R8373:Dpp10	UTSW	1	123854229	missense	possibly damaging	0.94
R8434:Dpp10	UTSW	1	123433010	missense	probably damaging	1.00
R9068:Dpp10	UTSW	1	123432938	missense	probably damaging	1.00
R9104:Dpp10	UTSW	1	123411755	missense	probably damaging	1.00
R9477:Dpp10	UTSW	1	123376641	missense	possibly damaging	0.46
R9492:Dpp10	UTSW	1	123353430	missense	probably damaging	1.00
R9524:Dpp10	UTSW	1	123336882	missense	probably damaging	1.00
R9576:Dpp10	UTSW	1	123341680	missense	probably damaging	1.00
R9631:Dpp10	UTSW	1	123341703	missense	probably damaging	1.00
R9736:Dpp10	UTSW	1	123334359	missense	possibly damaging	0.64
X0019:Dpp10	UTSW	1	123398585	missense	possibly damaging	0.88
X0020:Dpp10	UTSW	1	123398582	missense	probably benign	0.36
X0021:Dpp10	UTSW	1	123432992	missense	probably damaging	1.00
X0024:Dpp10	UTSW	1	123384286	missense	probably damaging	1.00
Z1176:Dpp10	UTSW	1	123353440	nonsense	probably null

Posted On

2015-04-16