Incidental Mutation 'IGL02326:Zfp235'
ID 288458
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp235
Ensembl Gene ENSMUSG00000047603
Gene Name zinc finger protein 235
Synonyms 0610030O19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02326
Quality Score
Status
Chromosome 7
Chromosomal Location 23833594-23842666 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 23834727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000050803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056549] [ENSMUST00000205680]
AlphaFold Q499D5
Predicted Effect probably null
Transcript: ENSMUST00000056549
AA Change: M1K

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000050803
Gene: ENSMUSG00000047603
AA Change: M1K

DomainStartEndE-ValueType
KRAB 8 71 1.09e-15 SMART
ZnF_C2H2 283 305 1.79e-2 SMART
ZnF_C2H2 311 333 3.16e-3 SMART
ZnF_C2H2 339 361 1.18e-2 SMART
ZnF_C2H2 367 389 6.99e-5 SMART
ZnF_C2H2 395 417 1.33e-1 SMART
ZnF_C2H2 423 445 3.16e-3 SMART
ZnF_C2H2 451 473 2.84e-5 SMART
ZnF_C2H2 479 501 6.32e-3 SMART
ZnF_C2H2 507 529 3.44e-4 SMART
ZnF_C2H2 535 557 2.12e-4 SMART
ZnF_C2H2 563 585 1.38e-3 SMART
ZnF_C2H2 591 613 2.27e-4 SMART
ZnF_C2H2 619 641 5.99e-4 SMART
ZnF_C2H2 647 669 5.9e-3 SMART
ZnF_C2H2 675 697 4.87e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000205680
AA Change: M1K

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205736
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205740
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205834
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206809
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432M17Rik T C 3: 121,465,051 (GRCm39) V29A unknown Het
Abcc8 C A 7: 45,772,281 (GRCm39) probably null Het
Ankar A T 1: 72,705,514 (GRCm39) I614N probably damaging Het
Ash1l G A 3: 88,873,364 (GRCm39) R49H probably benign Het
Atp8b1 T C 18: 64,671,654 (GRCm39) H1123R probably damaging Het
Casp12 T C 9: 5,358,317 (GRCm39) Y375H possibly damaging Het
Cbl A G 9: 44,062,770 (GRCm39) I861T possibly damaging Het
Cdh20 T C 1: 104,902,764 (GRCm39) L485P probably damaging Het
Cobl A T 11: 12,336,712 (GRCm39) N25K possibly damaging Het
Col14a1 T C 15: 55,282,193 (GRCm39) V818A unknown Het
Csmd3 G A 15: 47,619,359 (GRCm39) probably benign Het
Dpp6 A G 5: 27,869,755 (GRCm39) Y509C probably damaging Het
Fabp2 C T 3: 122,692,395 (GRCm39) R96C probably damaging Het
Fam53a T C 5: 33,757,938 (GRCm39) D395G probably damaging Het
Gabrb1 T A 5: 71,858,190 (GRCm39) I72K probably damaging Het
Hmcn2 G A 2: 31,340,964 (GRCm39) S4479N probably damaging Het
Hrnr C T 3: 93,231,052 (GRCm39) T430I unknown Het
Ighv1-53 T A 12: 115,122,235 (GRCm39) T47S probably benign Het
Ilk C A 7: 105,390,840 (GRCm39) P261Q probably damaging Het
Ints10 T G 8: 69,257,485 (GRCm39) D228E probably damaging Het
Kcnq5 A T 1: 21,472,816 (GRCm39) S782R probably benign Het
Map3k4 A G 17: 12,467,897 (GRCm39) S1046P probably damaging Het
Musk C T 4: 58,354,113 (GRCm39) P374S probably benign Het
Or52e18 T A 7: 104,609,853 (GRCm39) I29F probably benign Het
Or5b108 C A 19: 13,168,779 (GRCm39) Y249* probably null Het
Or5j1 G A 2: 86,879,355 (GRCm39) S75L possibly damaging Het
Or5w19 T A 2: 87,699,019 (GRCm39) I228N probably damaging Het
Pkd2 T C 5: 104,624,941 (GRCm39) Y246H probably benign Het
Plekha5 G T 6: 140,529,576 (GRCm39) G340* probably null Het
Plxna4 T A 6: 32,129,840 (GRCm39) M1828L probably damaging Het
Prex1 A G 2: 166,463,105 (GRCm39) I252T probably benign Het
Pura A G 18: 36,420,831 (GRCm39) D206G probably damaging Het
Rad54b T A 4: 11,612,713 (GRCm39) F782I probably damaging Het
Rbp4 T C 19: 38,112,563 (GRCm39) D90G probably damaging Het
Rita1 C T 5: 120,747,858 (GRCm39) A147T probably damaging Het
Scn7a C A 2: 66,530,392 (GRCm39) R651L probably benign Het
Sh2d3c A T 2: 32,639,163 (GRCm39) probably null Het
Slc43a1 T G 2: 84,680,115 (GRCm39) L87R probably damaging Het
Sppl2c A G 11: 104,078,099 (GRCm39) T300A probably benign Het
Srgap2 T A 1: 131,284,645 (GRCm39) probably null Het
Tkt G A 14: 30,294,182 (GRCm39) V531M probably damaging Het
Twsg1 T C 17: 66,233,431 (GRCm39) D173G possibly damaging Het
Ugt2b37 G T 5: 87,388,861 (GRCm39) H451N probably benign Het
Ugt2b38 C T 5: 87,571,592 (GRCm39) D147N probably damaging Het
Vmn1r15 T C 6: 57,235,255 (GRCm39) I41T probably benign Het
Vwa5a A T 9: 38,649,252 (GRCm39) T667S probably benign Het
Xrn2 A G 2: 146,889,633 (GRCm39) E672G probably benign Het
Zmym1 T C 4: 126,941,553 (GRCm39) E847G probably damaging Het
Other mutations in Zfp235
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Zfp235 APN 7 23,836,505 (GRCm39) missense probably damaging 1.00
R0107:Zfp235 UTSW 7 23,836,541 (GRCm39) missense probably damaging 1.00
R0271:Zfp235 UTSW 7 23,836,556 (GRCm39) missense possibly damaging 0.93
R0513:Zfp235 UTSW 7 23,841,644 (GRCm39) missense probably damaging 1.00
R1004:Zfp235 UTSW 7 23,840,169 (GRCm39) missense probably damaging 1.00
R1928:Zfp235 UTSW 7 23,840,563 (GRCm39) nonsense probably null
R1958:Zfp235 UTSW 7 23,839,771 (GRCm39) missense probably damaging 0.98
R2167:Zfp235 UTSW 7 23,840,387 (GRCm39) missense possibly damaging 0.80
R2511:Zfp235 UTSW 7 23,841,549 (GRCm39) missense probably damaging 1.00
R3013:Zfp235 UTSW 7 23,840,157 (GRCm39) missense probably damaging 0.98
R3806:Zfp235 UTSW 7 23,840,046 (GRCm39) missense probably benign 0.01
R4613:Zfp235 UTSW 7 23,841,101 (GRCm39) missense probably damaging 1.00
R4876:Zfp235 UTSW 7 23,840,384 (GRCm39) missense probably benign 0.01
R4977:Zfp235 UTSW 7 23,841,609 (GRCm39) missense possibly damaging 0.94
R5085:Zfp235 UTSW 7 23,836,546 (GRCm39) missense probably damaging 0.96
R5664:Zfp235 UTSW 7 23,841,576 (GRCm39) missense probably damaging 1.00
R6440:Zfp235 UTSW 7 23,840,040 (GRCm39) missense probably damaging 0.96
R6650:Zfp235 UTSW 7 23,836,463 (GRCm39) splice site probably null
R7694:Zfp235 UTSW 7 23,841,525 (GRCm39) missense probably benign 0.37
R8031:Zfp235 UTSW 7 23,841,114 (GRCm39) missense probably benign 0.19
R8188:Zfp235 UTSW 7 23,841,296 (GRCm39) missense probably damaging 1.00
R8744:Zfp235 UTSW 7 23,839,924 (GRCm39) missense possibly damaging 0.56
R9115:Zfp235 UTSW 7 23,841,453 (GRCm39) missense probably damaging 1.00
R9244:Zfp235 UTSW 7 23,839,919 (GRCm39) missense probably benign 0.00
R9401:Zfp235 UTSW 7 23,841,551 (GRCm39) missense probably damaging 1.00
R9404:Zfp235 UTSW 7 23,839,862 (GRCm39) missense possibly damaging 0.92
R9523:Zfp235 UTSW 7 23,840,381 (GRCm39) missense probably benign 0.00
R9563:Zfp235 UTSW 7 23,841,669 (GRCm39) missense possibly damaging 0.91
Posted On 2015-04-16