Incidental Mutation 'IGL02326:Olfr1106'
ID288484
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1106
Ensembl Gene ENSMUSG00000075164
Gene Nameolfactory receptor 1106
SynonymsMOR172-6, MOR172-8_p, GA_x6K02T2Q125-48541463-48540525
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL02326
Quality Score
Status
Chromosome2
Chromosomal Location87046811-87052273 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 87049011 bp
ZygosityHeterozygous
Amino Acid Change Serine to Leucine at position 75 (S75L)
Ref Sequence ENSEMBL: ENSMUSP00000149092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099867] [ENSMUST00000213781] [ENSMUST00000217650]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099867
AA Change: S75L

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097452
Gene: ENSMUSG00000075164
AA Change: S75L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.2e-53 PFAM
Pfam:7tm_1 41 290 1e-16 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213781
AA Change: S75L

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217650
AA Change: S75L

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432M17Rik T C 3: 121,671,402 V29A unknown Het
Abcc8 C A 7: 46,122,857 probably null Het
Ankar A T 1: 72,666,355 I614N probably damaging Het
Ash1l G A 3: 88,966,057 R49H probably benign Het
Atp8b1 T C 18: 64,538,583 H1123R probably damaging Het
Casp12 T C 9: 5,358,317 Y375H possibly damaging Het
Cbl A G 9: 44,151,473 I861T possibly damaging Het
Cdh20 T C 1: 104,975,039 L485P probably damaging Het
Cobl A T 11: 12,386,712 N25K possibly damaging Het
Col14a1 T C 15: 55,418,797 V818A unknown Het
Csmd3 G A 15: 47,755,963 probably benign Het
Dpp6 A G 5: 27,664,757 Y509C probably damaging Het
Fabp2 C T 3: 122,898,746 R96C probably damaging Het
Fam53a T C 5: 33,600,594 D395G probably damaging Het
Gabrb1 T A 5: 71,700,847 I72K probably damaging Het
Hmcn2 G A 2: 31,450,952 S4479N probably damaging Het
Hrnr C T 3: 93,323,745 T430I unknown Het
Ighv1-53 T A 12: 115,158,615 T47S probably benign Het
Ilk C A 7: 105,741,633 P261Q probably damaging Het
Ints10 T G 8: 68,804,833 D228E probably damaging Het
Kcnq5 A T 1: 21,402,592 S782R probably benign Het
Map3k4 A G 17: 12,249,010 S1046P probably damaging Het
Musk C T 4: 58,354,113 P374S probably benign Het
Olfr1152 T A 2: 87,868,675 I228N probably damaging Het
Olfr1462 C A 19: 13,191,415 Y249* probably null Het
Olfr670 T A 7: 104,960,646 I29F probably benign Het
Pkd2 T C 5: 104,477,075 Y246H probably benign Het
Plekha5 G T 6: 140,583,850 G340* probably null Het
Plxna4 T A 6: 32,152,905 M1828L probably damaging Het
Prex1 A G 2: 166,621,185 I252T probably benign Het
Pura A G 18: 36,287,778 D206G probably damaging Het
Rad54b T A 4: 11,612,713 F782I probably damaging Het
Rbp4 T C 19: 38,124,115 D90G probably damaging Het
Rita1 C T 5: 120,609,793 A147T probably damaging Het
Scn7a C A 2: 66,700,048 R651L probably benign Het
Sh2d3c A T 2: 32,749,151 probably null Het
Slc43a1 T G 2: 84,849,771 L87R probably damaging Het
Sppl2c A G 11: 104,187,273 T300A probably benign Het
Srgap2 T A 1: 131,356,907 probably null Het
Tkt G A 14: 30,572,225 V531M probably damaging Het
Twsg1 T C 17: 65,926,436 D173G possibly damaging Het
Ugt2b37 G T 5: 87,241,002 H451N probably benign Het
Ugt2b38 C T 5: 87,423,733 D147N probably damaging Het
Vmn1r15 T C 6: 57,258,270 I41T probably benign Het
Vwa5a A T 9: 38,737,956 T667S probably benign Het
Xrn2 A G 2: 147,047,713 E672G probably benign Het
Zfp235 T A 7: 24,135,302 M1K probably null Het
Zmym1 T C 4: 127,047,760 E847G probably damaging Het
Other mutations in Olfr1106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01610:Olfr1106 APN 2 87048288 utr 3 prime probably benign
IGL03087:Olfr1106 APN 2 87049012 missense possibly damaging 0.90
R0040:Olfr1106 UTSW 2 87049204 missense probably damaging 1.00
R0256:Olfr1106 UTSW 2 87049056 missense probably damaging 1.00
R0487:Olfr1106 UTSW 2 87048493 missense probably damaging 0.96
R0730:Olfr1106 UTSW 2 87049148 missense probably benign 0.00
R1978:Olfr1106 UTSW 2 87048835 missense possibly damaging 0.83
R5335:Olfr1106 UTSW 2 87049165 missense probably damaging 1.00
R6611:Olfr1106 UTSW 2 87049233 start codon destroyed probably null 1.00
R6681:Olfr1106 UTSW 2 87048598 missense probably benign 0.22
R7322:Olfr1106 UTSW 2 87048479 nonsense probably null
R7584:Olfr1106 UTSW 2 87049134 missense probably benign 0.19
R7731:Olfr1106 UTSW 2 87049234 start codon destroyed probably null 0.99
R8011:Olfr1106 UTSW 2 87048846 missense probably damaging 1.00
Z1088:Olfr1106 UTSW 2 87048433 missense probably benign 0.00
Posted On2015-04-16