Incidental Mutation 'IGL02327:Olfr224'
ID288510
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr224
Ensembl Gene ENSMUSG00000059279
Gene Nameolfactory receptor 224
SynonymsGA_x6K02T2NKPP-858022-858862, Olfr327-ps1, MOR275-10_p, GA_x6K02T00261-652-347, MOR275-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL02327
Quality Score
Status
Chromosome11
Chromosomal Location58565856-58570553 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 58566935 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Tryptophan at position 137 (R137W)
Ref Sequence ENSEMBL: ENSMUSP00000150268 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081102] [ENSMUST00000215322] [ENSMUST00000216758] [ENSMUST00000217009]
Predicted Effect probably damaging
Transcript: ENSMUST00000081102
AA Change: R137W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079881
Gene: ENSMUSG00000059279
AA Change: R137W

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.4e-35 PFAM
Pfam:7tm_4 137 281 5.8e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215322
AA Change: R137W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216758
AA Change: R137W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217009
AA Change: R137W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd9 A T 12: 110,977,415 C29S probably damaging Het
Ccdc66 G A 14: 27,493,386 A399V probably damaging Het
Ccl12 A G 11: 82,103,122 I68M possibly damaging Het
Cd244 T C 1: 171,559,341 V6A probably benign Het
Cfap97 T A 8: 46,170,142 S190T probably damaging Het
Chic2 G T 5: 75,027,080 C106* probably null Het
Ctdsp2 G A 10: 126,996,382 D237N probably benign Het
Cyp2a22 A T 7: 26,934,781 M316K probably damaging Het
Cyp3a25 A G 5: 145,986,921 F304S possibly damaging Het
Ddc A T 11: 11,863,739 V209D probably damaging Het
Dhx16 A G 17: 35,883,825 K446R probably benign Het
Fgd3 T C 13: 49,285,798 K241E probably damaging Het
Hps1 G T 19: 42,756,345 probably benign Het
Inpp4b C T 8: 82,041,962 T700I probably benign Het
Kremen2 T A 17: 23,743,569 M157L probably benign Het
Lrwd1 T C 5: 136,123,464 Y582C probably damaging Het
Macf1 T A 4: 123,471,730 R1514S probably benign Het
Mex3c T A 18: 73,590,710 C625S probably damaging Het
Mical1 G A 10: 41,486,664 E932K possibly damaging Het
Ncf2 A T 1: 152,816,993 Y87F possibly damaging Het
Neo1 T C 9: 58,903,088 T1027A probably benign Het
Nfkbib G T 7: 28,759,143 P347Q probably benign Het
Nr1h2 G A 7: 44,551,500 probably benign Het
Olfr1158 A T 2: 87,990,257 I49F probably damaging Het
Olfr384 A T 11: 73,603,155 T192S probably damaging Het
Oxct1 A G 15: 4,037,089 probably null Het
Pak1ip1 T G 13: 41,012,417 N308K probably benign Het
Prpf38a T C 4: 108,568,410 R224G unknown Het
Scfd1 T C 12: 51,389,317 V83A possibly damaging Het
Tmem131 C T 1: 36,799,022 G1545D probably damaging Het
Trav13n-4 A T 14: 53,364,110 probably benign Het
Ttc3 A G 16: 94,448,108 D1155G probably damaging Het
Unc80 G A 1: 66,641,673 V2143I probably benign Het
Vmn2r16 T C 5: 109,340,121 Y287H probably benign Het
Vmn2r59 A G 7: 42,012,231 V720A probably benign Het
Wars T A 12: 108,866,301 probably null Het
Wdcp A G 12: 4,851,115 K324E possibly damaging Het
Wdfy3 A T 5: 101,888,192 L2105H probably damaging Het
Xirp2 A T 2: 67,510,100 D895V probably damaging Het
Zscan10 A T 17: 23,607,572 probably benign Het
Other mutations in Olfr224
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Olfr224 APN 11 58566767 missense probably damaging 1.00
IGL02904:Olfr224 APN 11 58566797 missense possibly damaging 0.61
IGL02968:Olfr224 APN 11 58567195 missense possibly damaging 0.90
R1704:Olfr224 UTSW 11 58566754 missense probably damaging 0.97
R2055:Olfr224 UTSW 11 58566847 missense probably damaging 0.99
R3925:Olfr224 UTSW 11 58566826 missense probably benign 0.34
R4093:Olfr224 UTSW 11 58566829 missense probably damaging 1.00
R4902:Olfr224 UTSW 11 58566625 missense possibly damaging 0.60
R4955:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R4956:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R4957:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R5436:Olfr224 UTSW 11 58566937 missense probably benign 0.34
R6699:Olfr224 UTSW 11 58567205 missense possibly damaging 0.69
R6825:Olfr224 UTSW 11 58566650 missense possibly damaging 0.89
R7467:Olfr224 UTSW 11 58566462 missense possibly damaging 0.82
R7590:Olfr224 UTSW 11 58567259 missense probably benign 0.09
R7600:Olfr224 UTSW 11 58567336 missense probably benign 0.17
R7725:Olfr224 UTSW 11 58566767 missense probably damaging 1.00
R8438:Olfr224 UTSW 11 58566839 missense possibly damaging 0.74
R8848:Olfr224 UTSW 11 58567076 missense probably damaging 1.00
R8867:Olfr224 UTSW 11 58566736 missense probably damaging 0.99
X0026:Olfr224 UTSW 11 58567174 missense possibly damaging 0.50
Z1186:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1186:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1186:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1187:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1187:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1187:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1188:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1188:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1188:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1189:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1189:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1189:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1190:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1190:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1190:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1191:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1191:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1191:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Z1192:Olfr224 UTSW 11 58566562 missense probably benign 0.02
Z1192:Olfr224 UTSW 11 58566695 missense probably benign 0.00
Z1192:Olfr224 UTSW 11 58567094 missense probably benign 0.02
Posted On2015-04-16