Incidental Mutation 'IGL02327:Or1e25'
ID 288512
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1e25
Ensembl Gene ENSMUSG00000060335
Gene Name olfactory receptor family 1 subfamily E member 25
Synonyms GA_x6K02T2P1NL-3739520-3740032, Olfr384, Olfr386, GA_x6K02T2P1NL-3773152-3774090, MOR135-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # IGL02327
Quality Score
Status
Chromosome 11
Chromosomal Location 73493408-73494346 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73493981 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 192 (T192S)
Ref Sequence ENSEMBL: ENSMUSP00000148997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072993] [ENSMUST00000214228]
AlphaFold Q7TRX8
Predicted Effect probably damaging
Transcript: ENSMUST00000072993
AA Change: T192S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000072758
Gene: ENSMUSG00000060335
AA Change: T192S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.6e-9 PFAM
Pfam:7tm_1 41 290 1.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214228
AA Change: T192S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd9 A T 12: 110,943,849 (GRCm39) C29S probably damaging Het
Ccdc66 G A 14: 27,215,343 (GRCm39) A399V probably damaging Het
Ccl12 A G 11: 81,993,948 (GRCm39) I68M possibly damaging Het
Cd244a T C 1: 171,386,909 (GRCm39) V6A probably benign Het
Cfap97 T A 8: 46,623,179 (GRCm39) S190T probably damaging Het
Chic2 G T 5: 75,187,741 (GRCm39) C106* probably null Het
Ctdsp2 G A 10: 126,832,251 (GRCm39) D237N probably benign Het
Cyp2a22 A T 7: 26,634,206 (GRCm39) M316K probably damaging Het
Cyp3a25 A G 5: 145,923,731 (GRCm39) F304S possibly damaging Het
Ddc A T 11: 11,813,739 (GRCm39) V209D probably damaging Het
Dhx16 A G 17: 36,194,717 (GRCm39) K446R probably benign Het
Fgd3 T C 13: 49,439,274 (GRCm39) K241E probably damaging Het
Hps1 G T 19: 42,744,784 (GRCm39) probably benign Het
Inpp4b C T 8: 82,768,591 (GRCm39) T700I probably benign Het
Kremen2 T A 17: 23,962,543 (GRCm39) M157L probably benign Het
Lrwd1 T C 5: 136,152,318 (GRCm39) Y582C probably damaging Het
Macf1 T A 4: 123,365,523 (GRCm39) R1514S probably benign Het
Mex3c T A 18: 73,723,781 (GRCm39) C625S probably damaging Het
Mical1 G A 10: 41,362,660 (GRCm39) E932K possibly damaging Het
Ncf2 A T 1: 152,692,744 (GRCm39) Y87F possibly damaging Het
Neo1 T C 9: 58,810,371 (GRCm39) T1027A probably benign Het
Nfkbib G T 7: 28,458,568 (GRCm39) P347Q probably benign Het
Nr1h2 G A 7: 44,200,924 (GRCm39) probably benign Het
Or2t43 T A 11: 58,457,761 (GRCm39) R137W probably damaging Het
Or9m2 A T 2: 87,820,601 (GRCm39) I49F probably damaging Het
Oxct1 A G 15: 4,066,571 (GRCm39) probably null Het
Pak1ip1 T G 13: 41,165,893 (GRCm39) N308K probably benign Het
Prpf38a T C 4: 108,425,607 (GRCm39) R224G unknown Het
Scfd1 T C 12: 51,436,100 (GRCm39) V83A possibly damaging Het
Tmem131 C T 1: 36,838,103 (GRCm39) G1545D probably damaging Het
Trav13n-4 A T 14: 53,601,567 (GRCm39) probably benign Het
Ttc3 A G 16: 94,248,967 (GRCm39) D1155G probably damaging Het
Unc80 G A 1: 66,680,832 (GRCm39) V2143I probably benign Het
Vmn2r16 T C 5: 109,487,987 (GRCm39) Y287H probably benign Het
Vmn2r59 A G 7: 41,661,655 (GRCm39) V720A probably benign Het
Wars1 T A 12: 108,832,227 (GRCm39) probably null Het
Wdcp A G 12: 4,901,115 (GRCm39) K324E possibly damaging Het
Wdfy3 A T 5: 102,036,058 (GRCm39) L2105H probably damaging Het
Xirp2 A T 2: 67,340,444 (GRCm39) D895V probably damaging Het
Zscan10 A T 17: 23,826,546 (GRCm39) probably benign Het
Other mutations in Or1e25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or1e25 APN 11 73,494,056 (GRCm39) missense probably damaging 1.00
IGL01767:Or1e25 APN 11 73,493,858 (GRCm39) missense probably benign
IGL02296:Or1e25 APN 11 73,493,532 (GRCm39) missense probably damaging 1.00
IGL02740:Or1e25 APN 11 73,493,657 (GRCm39) missense probably benign 0.41
H8562:Or1e25 UTSW 11 73,494,273 (GRCm39) missense probably damaging 1.00
R0594:Or1e25 UTSW 11 73,494,218 (GRCm39) missense probably benign 0.03
R2038:Or1e25 UTSW 11 73,494,239 (GRCm39) missense probably damaging 1.00
R2127:Or1e25 UTSW 11 73,493,631 (GRCm39) missense possibly damaging 0.78
R2844:Or1e25 UTSW 11 73,494,209 (GRCm39) missense probably benign 0.12
R2846:Or1e25 UTSW 11 73,494,209 (GRCm39) missense probably benign 0.12
R3877:Or1e25 UTSW 11 73,493,979 (GRCm39) missense probably damaging 1.00
R4193:Or1e25 UTSW 11 73,494,243 (GRCm39) missense probably damaging 1.00
R4433:Or1e25 UTSW 11 73,493,712 (GRCm39) missense probably damaging 1.00
R4824:Or1e25 UTSW 11 73,493,426 (GRCm39) missense possibly damaging 0.61
R4851:Or1e25 UTSW 11 73,493,883 (GRCm39) missense probably damaging 1.00
R5285:Or1e25 UTSW 11 73,493,767 (GRCm39) nonsense probably null
R5326:Or1e25 UTSW 11 73,494,030 (GRCm39) missense possibly damaging 0.94
R5542:Or1e25 UTSW 11 73,494,030 (GRCm39) missense possibly damaging 0.94
R5662:Or1e25 UTSW 11 73,494,005 (GRCm39) missense probably benign 0.03
R6489:Or1e25 UTSW 11 73,494,265 (GRCm39) missense probably damaging 1.00
R6770:Or1e25 UTSW 11 73,493,804 (GRCm39) missense probably benign 0.04
R7131:Or1e25 UTSW 11 73,493,562 (GRCm39) missense possibly damaging 0.78
R7313:Or1e25 UTSW 11 73,493,810 (GRCm39) missense probably damaging 0.99
R7754:Or1e25 UTSW 11 73,494,332 (GRCm39) nonsense probably null
R8393:Or1e25 UTSW 11 73,494,261 (GRCm39) missense probably damaging 1.00
R9190:Or1e25 UTSW 11 73,493,877 (GRCm39) missense probably benign 0.36
R9628:Or1e25 UTSW 11 73,493,864 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16