Incidental Mutation 'IGL00930:Vmn1r199'
ID28855
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r199
Ensembl Gene ENSMUSG00000069292
Gene Namevomeronasal 1 receptor 199
SynonymsV1rh4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.099) question?
Stock #IGL00930
Quality Score
Status
Chromosome13
Chromosomal Location22379818-22388102 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22382859 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 108 (T108A)
Ref Sequence ENSEMBL: ENSMUSP00000153918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091732] [ENSMUST00000227685] [ENSMUST00000227689] [ENSMUST00000227846]
Predicted Effect possibly damaging
Transcript: ENSMUST00000091732
AA Change: T108A

PolyPhen 2 Score 0.636 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000089326
Gene: ENSMUSG00000069292
AA Change: T108A

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
Pfam:TAS2R 43 338 3.3e-7 PFAM
Pfam:V1R 75 340 1.6e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120663
Predicted Effect possibly damaging
Transcript: ENSMUST00000227685
AA Change: T108A

PolyPhen 2 Score 0.636 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227689
AA Change: T65A

PolyPhen 2 Score 0.552 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227846
AA Change: T65A

PolyPhen 2 Score 0.552 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 T C 7: 119,592,310 S534P possibly damaging Het
Adamts15 G A 9: 30,902,053 P939S probably damaging Het
Alms1 T C 6: 85,601,310 S207P probably damaging Het
Chd7 A G 4: 8,805,181 K747E probably damaging Het
Dock5 G T 14: 67,771,077 N1457K probably damaging Het
Donson T C 16: 91,682,591 E323G possibly damaging Het
Epc1 T A 18: 6,449,196 M434L probably benign Het
Fcer1a A G 1: 173,222,533 probably benign Het
Hemgn A T 4: 46,396,383 C284* probably null Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Olfr854 A G 9: 19,567,175 S67P probably damaging Het
Pcdh15 G A 10: 74,630,698 E1450K probably benign Het
Pfpl A T 19: 12,429,645 H420L probably benign Het
Pitpnm2 A G 5: 124,121,663 probably benign Het
Pole2 A G 12: 69,226,445 probably benign Het
Prmt3 T A 7: 49,792,009 Y245N probably damaging Het
Rpl10a T C 17: 28,329,007 Y41H probably damaging Het
Tpst1 A T 5: 130,102,134 K148N probably benign Het
Wdr7 T A 18: 63,740,244 C525* probably null Het
Zfp646 A G 7: 127,879,130 T160A possibly damaging Het
Other mutations in Vmn1r199
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01959:Vmn1r199 APN 13 22383120 missense probably benign 0.07
IGL02270:Vmn1r199 APN 13 22383006 missense probably damaging 1.00
IGL02687:Vmn1r199 APN 13 22382791 missense possibly damaging 0.91
IGL03143:Vmn1r199 APN 13 22383129 missense probably damaging 1.00
R0528:Vmn1r199 UTSW 13 22382566 missense probably benign
R1411:Vmn1r199 UTSW 13 22383501 missense probably benign 0.01
R2075:Vmn1r199 UTSW 13 22383265 missense probably damaging 1.00
R5057:Vmn1r199 UTSW 13 22383405 missense possibly damaging 0.93
R5824:Vmn1r199 UTSW 13 22383578 missense probably benign
R5977:Vmn1r199 UTSW 13 22383246 missense probably benign 0.08
R6019:Vmn1r199 UTSW 13 22382599 missense possibly damaging 0.85
R6419:Vmn1r199 UTSW 13 22383607 missense possibly damaging 0.66
R7624:Vmn1r199 UTSW 13 22382736 missense probably benign 0.00
R7637:Vmn1r199 UTSW 13 22382675 missense probably benign 0.05
R8505:Vmn1r199 UTSW 13 22383147 missense probably benign 0.01
Posted On2013-04-17