Incidental Mutation 'IGL02331:St7l'
ID 288685
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol St7l
Ensembl Gene ENSMUSG00000045576
Gene Name suppression of tumorigenicity 7-like
Synonyms St7r
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL02331
Quality Score
Status
Chromosome 3
Chromosomal Location 104864005-104930064 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 104926588 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 522 (T522A)
Ref Sequence ENSEMBL: ENSMUSP00000102380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059271] [ENSMUST00000106769] [ENSMUST00000183914] [ENSMUST00000200132]
AlphaFold Q8K4P7
Predicted Effect possibly damaging
Transcript: ENSMUST00000059271
AA Change: T554A

PolyPhen 2 Score 0.462 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058455
Gene: ENSMUSG00000045576
AA Change: T554A

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 559 1.6e-292 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106769
AA Change: T522A

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000102380
Gene: ENSMUSG00000045576
AA Change: T522A

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 420 8.2e-209 PFAM
Pfam:ST7 419 527 1.4e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000183914
SMART Domains Protein: ENSMUSP00000139266
Gene: ENSMUSG00000045576

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
low complexity region 107 120 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000200132
AA Change: T476A

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000143759
Gene: ENSMUSG00000045576
AA Change: T476A

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 212 2.7e-81 PFAM
Pfam:ST7 209 481 1.3e-167 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace T G 11: 105,971,344 F241L possibly damaging Het
Alx1 A G 10: 103,022,299 F180L possibly damaging Het
Apaf1 T C 10: 91,059,619 D428G probably damaging Het
Arap2 G T 5: 62,649,682 probably benign Het
Arnt2 A G 7: 84,265,624 Y511H probably damaging Het
Bmp7 A T 2: 172,872,931 C362S probably damaging Het
Bpifb9a A G 2: 154,262,387 D250G possibly damaging Het
Ccnk T A 12: 108,189,084 L100H probably damaging Het
Cdh23 T C 10: 60,465,543 I451V probably damaging Het
Cemip A G 7: 83,963,984 probably null Het
Cep78 T A 19: 15,974,415 Q342L probably benign Het
Clca3b T C 3: 144,841,406 probably benign Het
Cpb2 A G 14: 75,283,404 R420G possibly damaging Het
Cyp2c50 A T 19: 40,090,943 probably null Het
Dbnl T C 11: 5,799,997 *433R probably null Het
Elovl5 T C 9: 77,979,899 S191P possibly damaging Het
Fbxo42 A G 4: 141,167,846 E40G probably benign Het
Fpgt T C 3: 155,087,862 D176G possibly damaging Het
Gm1110 C A 9: 26,913,287 probably null Het
Grik4 A T 9: 42,541,988 S700R probably damaging Het
Herc4 T C 10: 63,264,160 S121P probably benign Het
Hps4 T C 5: 112,369,536 V263A probably benign Het
Hsd11b1 A C 1: 193,240,616 L81R probably damaging Het
Ift122 T C 6: 115,887,324 M310T probably damaging Het
Isg20l2 G T 3: 87,932,087 V202L probably damaging Het
Klf3 A G 5: 64,829,072 K111E probably damaging Het
Kxd1 T C 8: 70,515,440 T128A probably benign Het
Lgals7 A G 7: 28,865,718 T94A probably benign Het
Lrp5 T C 19: 3,591,816 H1382R possibly damaging Het
Muc6 T C 7: 141,640,459 T1434A possibly damaging Het
Mybl2 C T 2: 163,074,685 R419W probably damaging Het
Myo5b A T 18: 74,638,040 probably null Het
Myo7a A G 7: 98,053,182 V2138A possibly damaging Het
Naip1 T A 13: 100,426,796 K620N probably benign Het
Ntrk2 T C 13: 58,846,856 probably null Het
Olfr935 A G 9: 38,995,106 S110P probably damaging Het
Osbpl5 A G 7: 143,709,795 V105A probably benign Het
Pfkp A C 13: 6,597,960 F527V probably benign Het
Pilra C A 5: 137,835,655 G47* probably null Het
Pkdrej C A 15: 85,821,327 C136F probably damaging Het
Ppp1r16a T A 15: 76,691,000 M36K probably benign Het
Rita1 C T 5: 120,609,793 A147T probably damaging Het
Rnf40 T C 7: 127,589,827 V124A probably benign Het
Stox2 G A 8: 47,191,944 P891L probably damaging Het
Trbv12-1 T C 6: 41,114,038 S115P probably damaging Het
Trpm1 A G 7: 64,235,052 D827G probably benign Het
Ttll6 T A 11: 96,135,747 M119K probably damaging Het
Ufl1 C A 4: 25,251,971 C568F probably damaging Het
Usp29 A T 7: 6,962,156 I333F probably benign Het
Vta1 G A 10: 14,705,394 T23M probably damaging Het
Zswim8 A G 14: 20,723,257 D1771G probably damaging Het
Other mutations in St7l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00785:St7l APN 3 104873579 splice site probably benign
IGL00919:St7l APN 3 104926466 missense probably damaging 1.00
IGL00945:St7l APN 3 104926482 missense probably damaging 0.96
IGL01644:St7l APN 3 104919456 nonsense probably null
IGL02158:St7l APN 3 104874832 missense possibly damaging 0.48
IGL02164:St7l APN 3 104922281 critical splice donor site probably null
IGL03220:St7l APN 3 104874823 splice site probably benign
R0118:St7l UTSW 3 104889303 missense probably damaging 0.97
R0320:St7l UTSW 3 104870913 nonsense probably null
R0345:St7l UTSW 3 104895809 splice site probably benign
R0714:St7l UTSW 3 104874928 missense probably benign 0.06
R0784:St7l UTSW 3 104870924 missense probably benign 0.13
R1664:St7l UTSW 3 104870898 missense probably damaging 1.00
R1719:St7l UTSW 3 104870987 missense probably benign 0.00
R1800:St7l UTSW 3 104919496 missense probably damaging 1.00
R1882:St7l UTSW 3 104868047 missense probably damaging 1.00
R3692:St7l UTSW 3 104891554 missense probably benign 0.27
R3879:St7l UTSW 3 104926447 missense probably damaging 1.00
R5130:St7l UTSW 3 104895764 missense probably damaging 1.00
R5271:St7l UTSW 3 104868060 missense probably damaging 1.00
R5887:St7l UTSW 3 104874928 missense probably benign 0.06
R6191:St7l UTSW 3 104868033 missense probably damaging 1.00
R6252:St7l UTSW 3 104919503 critical splice donor site probably null
R7307:St7l UTSW 3 104889353 missense probably benign 0.03
R7442:St7l UTSW 3 104889329 missense possibly damaging 0.93
R7860:St7l UTSW 3 104926577 missense probably benign 0.05
R8523:St7l UTSW 3 104868057 missense probably damaging 1.00
R8934:St7l UTSW 3 104889318 missense probably damaging 1.00
R8935:St7l UTSW 3 104870888 missense probably damaging 1.00
Z1177:St7l UTSW 3 104865309 critical splice donor site probably null
Posted On 2015-04-16