Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02331:Clca3b'

288701

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clca3b

Ensembl Gene

ENSMUSG00000037033

Gene Name

chloride channel accessory 3B

Synonyms

Clca4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02331

Quality Score

Status

Chromosome

Chromosomal Location

144822623-144849357 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 144841406 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159989]

AlphaFold

E9PUL3

Predicted Effect

probably benign
Transcript: ENSMUST00000159989

SMART Domains

Protein: ENSMUSP00000124581
Gene: ENSMUSG00000037033

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
VWA	306	481	6.22e-19	SMART
FN3	762	861	4.93e0	SMART
low complexity region	880	1025	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace	T	G	11: 105,971,344	F241L	possibly damaging	Het
Alx1	A	G	10: 103,022,299	F180L	possibly damaging	Het
Apaf1	T	C	10: 91,059,619	D428G	probably damaging	Het
Arap2	G	T	5: 62,649,682		probably benign	Het
Arnt2	A	G	7: 84,265,624	Y511H	probably damaging	Het
Bmp7	A	T	2: 172,872,931	C362S	probably damaging	Het
Bpifb9a	A	G	2: 154,262,387	D250G	possibly damaging	Het
Ccnk	T	A	12: 108,189,084	L100H	probably damaging	Het
Cdh23	T	C	10: 60,465,543	I451V	probably damaging	Het
Cemip	A	G	7: 83,963,984		probably null	Het
Cep78	T	A	19: 15,974,415	Q342L	probably benign	Het
Cpb2	A	G	14: 75,283,404	R420G	possibly damaging	Het
Cyp2c50	A	T	19: 40,090,943		probably null	Het
Dbnl	T	C	11: 5,799,997	*433R	probably null	Het
Elovl5	T	C	9: 77,979,899	S191P	possibly damaging	Het
Fbxo42	A	G	4: 141,167,846	E40G	probably benign	Het
Fpgt	T	C	3: 155,087,862	D176G	possibly damaging	Het
Gm1110	C	A	9: 26,913,287		probably null	Het
Grik4	A	T	9: 42,541,988	S700R	probably damaging	Het
Herc4	T	C	10: 63,264,160	S121P	probably benign	Het
Hps4	T	C	5: 112,369,536	V263A	probably benign	Het
Hsd11b1	A	C	1: 193,240,616	L81R	probably damaging	Het
Ift122	T	C	6: 115,887,324	M310T	probably damaging	Het
Isg20l2	G	T	3: 87,932,087	V202L	probably damaging	Het
Klf3	A	G	5: 64,829,072	K111E	probably damaging	Het
Kxd1	T	C	8: 70,515,440	T128A	probably benign	Het
Lgals7	A	G	7: 28,865,718	T94A	probably benign	Het
Lrp5	T	C	19: 3,591,816	H1382R	possibly damaging	Het
Muc6	T	C	7: 141,640,459	T1434A	possibly damaging	Het
Mybl2	C	T	2: 163,074,685	R419W	probably damaging	Het
Myo5b	A	T	18: 74,638,040		probably null	Het
Myo7a	A	G	7: 98,053,182	V2138A	possibly damaging	Het
Naip1	T	A	13: 100,426,796	K620N	probably benign	Het
Ntrk2	T	C	13: 58,846,856		probably null	Het
Olfr935	A	G	9: 38,995,106	S110P	probably damaging	Het
Osbpl5	A	G	7: 143,709,795	V105A	probably benign	Het
Pfkp	A	C	13: 6,597,960	F527V	probably benign	Het
Pilra	C	A	5: 137,835,655	G47*	probably null	Het
Pkdrej	C	A	15: 85,821,327	C136F	probably damaging	Het
Ppp1r16a	T	A	15: 76,691,000	M36K	probably benign	Het
Rita1	C	T	5: 120,609,793	A147T	probably damaging	Het
Rnf40	T	C	7: 127,589,827	V124A	probably benign	Het
St7l	A	G	3: 104,926,588	T522A	probably damaging	Het
Stox2	G	A	8: 47,191,944	P891L	probably damaging	Het
Trbv12-1	T	C	6: 41,114,038	S115P	probably damaging	Het
Trpm1	A	G	7: 64,235,052	D827G	probably benign	Het
Ttll6	T	A	11: 96,135,747	M119K	probably damaging	Het
Ufl1	C	A	4: 25,251,971	C568F	probably damaging	Het
Usp29	A	T	7: 6,962,156	I333F	probably benign	Het
Vta1	G	A	10: 14,705,394	T23M	probably damaging	Het
Zswim8	A	G	14: 20,723,257	D1771G	probably damaging	Het

Other mutations in Clca3b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Clca3b	APN	3	144836632	missense	probably damaging	0.96
IGL00425:Clca3b	APN	3	144836581	missense	probably benign	0.14
IGL00725:Clca3b	APN	3	144839162	missense	probably benign	0.01
IGL00898:Clca3b	APN	3	144844628	splice site	probably benign
IGL00953:Clca3b	APN	3	144847211	nonsense	probably null
IGL01089:Clca3b	APN	3	144823522	missense	probably benign
IGL01376:Clca3b	APN	3	144826051	missense	possibly damaging	0.60
IGL01996:Clca3b	APN	3	144849163	missense	probably benign	0.04
IGL02022:Clca3b	APN	3	144841410	critical splice donor site	probably null
IGL02200:Clca3b	APN	3	144841429	missense	probably damaging	1.00
IGL02314:Clca3b	APN	3	144828142	splice site	probably benign
IGL02429:Clca3b	APN	3	144828135	missense	probably damaging	1.00
IGL02868:Clca3b	APN	3	144827564	missense	probably damaging	1.00
IGL03095:Clca3b	APN	3	144846910	nonsense	probably null
IGL03331:Clca3b	APN	3	144827963	missense	probably benign
R0242:Clca3b	UTSW	3	144841465	missense	probably benign	0.00
R0242:Clca3b	UTSW	3	144841465	missense	probably benign	0.00
R0506:Clca3b	UTSW	3	144822866	unclassified	probably benign
R0524:Clca3b	UTSW	3	144825321	missense	probably benign
R0637:Clca3b	UTSW	3	144827940	missense	probably benign	0.03
R1577:Clca3b	UTSW	3	144823519	missense	probably damaging	1.00
R1641:Clca3b	UTSW	3	144823513	missense	possibly damaging	0.53
R1680:Clca3b	UTSW	3	144837824	missense	probably damaging	1.00
R2240:Clca3b	UTSW	3	144825935	missense	probably benign	0.22
R2248:Clca3b	UTSW	3	144825219	missense	probably benign	0.01
R2259:Clca3b	UTSW	3	144846381	missense	possibly damaging	0.80
R2920:Clca3b	UTSW	3	144837853	missense	probably benign	0.31
R2920:Clca3b	UTSW	3	144846931	missense	probably benign	0.01
R4355:Clca3b	UTSW	3	144825458	splice site	probably null
R4691:Clca3b	UTSW	3	144839092	missense	probably benign	0.02
R4828:Clca3b	UTSW	3	144844512	missense	probably benign	0.02
R4845:Clca3b	UTSW	3	144825270	missense	probably benign
R5182:Clca3b	UTSW	3	144828015	missense	probably damaging	0.99
R5396:Clca3b	UTSW	3	144847171	missense	probably damaging	0.99
R5429:Clca3b	UTSW	3	144846459	missense	probably damaging	1.00
R5572:Clca3b	UTSW	3	144827309	missense	probably damaging	1.00
R5657:Clca3b	UTSW	3	144827383	missense	probably benign	0.25
R5845:Clca3b	UTSW	3	144825316	missense	possibly damaging	0.46
R6505:Clca3b	UTSW	3	144825259	missense	probably benign	0.18
R6677:Clca3b	UTSW	3	144823384	missense	probably benign	0.13
R6707:Clca3b	UTSW	3	144844527	missense	probably benign	0.00
R7001:Clca3b	UTSW	3	144827972	missense	possibly damaging	0.48
R7285:Clca3b	UTSW	3	144837758	missense	probably benign	0.00
R7323:Clca3b	UTSW	3	144825920	missense	possibly damaging	0.60
R7324:Clca3b	UTSW	3	144841420	missense	possibly damaging	0.81
R7334:Clca3b	UTSW	3	144836656	nonsense	probably null
R7403:Clca3b	UTSW	3	144823498	missense	probably benign	0.00
R7798:Clca3b	UTSW	3	144828130	missense	probably damaging	1.00
R8008:Clca3b	UTSW	3	144844609	missense	probably benign	0.44
R8132:Clca3b	UTSW	3	144847174	missense	probably benign	0.13
R8181:Clca3b	UTSW	3	144839137	missense	probably benign	0.00
R8305:Clca3b	UTSW	3	144825937	missense	probably damaging	1.00
R8546:Clca3b	UTSW	3	144827397	missense	probably damaging	0.99
R8716:Clca3b	UTSW	3	144844594	missense	probably benign	0.14
R8804:Clca3b	UTSW	3	144839137	missense	probably benign	0.00
R8966:Clca3b	UTSW	3	144839111	missense	probably benign	0.27
R9003:Clca3b	UTSW	3	144827311	nonsense	probably null
R9455:Clca3b	UTSW	3	144823262	missense	unknown
R9470:Clca3b	UTSW	3	144837695	missense	probably damaging	1.00
R9658:Clca3b	UTSW	3	144837814	missense	probably damaging	0.98
R9760:Clca3b	UTSW	3	144846849	missense	probably benign	0.01

Posted On

2015-04-16