Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02332:Myo1g'

288743

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myo1g

Ensembl Gene

ENSMUSG00000020437

Gene Name

myosin IG

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02332

Quality Score

Status

Chromosome

Chromosomal Location

6506548-6520965 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 6520766 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 30 (D30G)

Ref Sequence

ENSEMBL: ENSMUSP00000003459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003459] [ENSMUST00000134489] [ENSMUST00000144725] [ENSMUST00000146536]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000003459
AA Change: D30G

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000003459
Gene: ENSMUSG00000020437
AA Change: D30G

Domain	Start	End	E-Value	Type
MYSc	9	714	N/A	SMART
IQ	715	737	2.79e0	SMART
Pfam:Myosin_TH1	821	1024	2.8e-42	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124818

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129570

Predicted Effect

probably benign
Transcript: ENSMUST00000134489

SMART Domains

Protein: ENSMUSP00000122356
Gene: ENSMUSG00000020437

Domain	Start	End	E-Value	Type
Pfam:Myosin_head	51	99	5.9e-15	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000144725
AA Change: D30G

SMART Domains

Protein: ENSMUSP00000120975
Gene: ENSMUSG00000020437
AA Change: D30G

Domain	Start	End	E-Value	Type
Blast:MYSc	9	43	8e-14	BLAST
low complexity region	48	60	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000146536
AA Change: D30G

SMART Domains

Protein: ENSMUSP00000122438
Gene: ENSMUSG00000020437
AA Change: D30G

Domain	Start	End	E-Value	Type
Blast:MYSc	9	38	2e-13	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147762

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156878

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018B24Rik	A	G	3: 48,608,888		noncoding transcript	Het
Abca13	A	T	11: 9,291,482	Y1115F	probably damaging	Het
Adam29	T	A	8: 55,871,740	I560F	probably damaging	Het
Bivm	T	C	1: 44,128,720		probably benign	Het
Brinp1	C	A	4: 68,904,884	R24L	probably benign	Het
Cnga1	A	G	5: 72,604,486	Y562H	probably damaging	Het
Cr2	C	A	1: 195,160,322	Q256H	probably benign	Het
Dhcr7	A	T	7: 143,843,128	N119I	probably damaging	Het
Dio1	A	T	4: 107,293,781	Y169N	probably damaging	Het
Dmbt1	C	T	7: 131,066,613		probably benign	Het
Eogt	T	G	6: 97,125,605	H249P	probably damaging	Het
Ermard	A	C	17: 14,990,545		probably null	Het
Exoc4	T	C	6: 33,249,240		probably null	Het
Fxr2	G	T	11: 69,649,838		probably null	Het
Glyr1	G	T	16: 5,018,953	T443N	probably damaging	Het
Gm14137	T	G	2: 119,175,326	L122R	probably damaging	Het
Gm4845	C	A	1: 141,256,597		noncoding transcript	Het
Gm8258	A	G	5: 104,775,902		noncoding transcript	Het
Gmps	G	A	3: 63,990,569	R258H	probably benign	Het
Itga6	T	G	2: 71,838,373	L552R	possibly damaging	Het
Itgam	T	A	7: 128,085,674		probably null	Het
Itgb5	G	T	16: 33,920,130	E224*	probably null	Het
Itih4	C	A	14: 30,887,860	A49D	probably damaging	Het
Itpr2	A	T	6: 146,426,542	N64K	probably damaging	Het
Moap1	T	C	12: 102,742,807	Y161C	probably benign	Het
Mst1r	G	T	9: 107,907,826	G228*	probably null	Het
Ndn	T	A	7: 62,348,825	C140S	probably damaging	Het
Nek5	G	T	8: 22,095,261	Q367K	probably benign	Het
Nrd1	A	T	4: 109,000,988	R52S	probably damaging	Het
Nup133	A	T	8: 123,907,832	L1007Q	probably damaging	Het
Olfr1105	T	C	2: 87,034,212	D3G	probably benign	Het
Olfr633	T	C	7: 103,946,920	M118T	probably damaging	Het
Olfr74	A	T	2: 87,974,065	L200Q	probably damaging	Het
P2rx2	T	C	5: 110,341,805	S116G	probably benign	Het
Pcdhb13	G	A	18: 37,443,582	V338M	probably benign	Het
Pdcl2	A	T	5: 76,319,135	Y70*	probably null	Het
Ppm1e	T	C	11: 87,231,742	H463R	probably benign	Het
Ppm1f	T	A	16: 16,914,087	C134S	possibly damaging	Het
Ppp2r3a	A	G	9: 101,180,403	F180L	possibly damaging	Het
Pxn	A	G	5: 115,544,926	S96G	probably benign	Het
Rasa4	G	T	5: 136,095,599	Q167H	probably benign	Het
Rfx8	T	C	1: 39,718,480	I43V	possibly damaging	Het
Sez6	C	T	11: 77,954,742		probably benign	Het
Slc39a6	A	T	18: 24,589,823	D473E	probably benign	Het
Spocd1	A	G	4: 129,949,092	D68G	probably damaging	Het
Syt13	T	C	2: 92,940,804	F79L	probably benign	Het
Tas2r103	A	T	6: 133,036,512	M197K	probably benign	Het
Tbrg4	A	G	11: 6,618,492	V429A	probably damaging	Het
Tuft1	A	C	3: 94,615,768		probably null	Het
Uqcrc1	A	G	9: 108,947,869	T80A	probably damaging	Het
Vps18	A	G	2: 119,293,810	N406S	probably benign	Het
Xrn2	T	A	2: 147,026,590	W188R	probably damaging	Het
Zzef1	T	G	11: 72,916,509	S2738A	probably benign	Het

Other mutations in Myo1g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Myo1g	APN	11	6515856	missense	possibly damaging	0.70
IGL01608:Myo1g	APN	11	6516780	missense	possibly damaging	0.61
IGL01679:Myo1g	APN	11	6518006	missense	possibly damaging	0.90
IGL01830:Myo1g	APN	11	6514522	nonsense	probably null
IGL02813:Myo1g	APN	11	6518743	makesense	probably null
IGL02988:Myo1g	APN	11	6508183	splice site	probably benign
IGL03178:Myo1g	APN	11	6512181	missense	probably damaging	1.00
R0004:Myo1g	UTSW	11	6515901	missense	probably damaging	1.00
R0334:Myo1g	UTSW	11	6511084	splice site	probably benign
R0513:Myo1g	UTSW	11	6510203	missense	probably benign	0.00
R0730:Myo1g	UTSW	11	6520794	missense	probably damaging	1.00
R1054:Myo1g	UTSW	11	6518987	missense	probably damaging	1.00
R1434:Myo1g	UTSW	11	6509372	missense	probably benign	0.00
R1500:Myo1g	UTSW	11	6520811	missense	probably benign
R1513:Myo1g	UTSW	11	6515140	missense	probably damaging	0.99
R1720:Myo1g	UTSW	11	6512490	missense	probably benign	0.44
R1774:Myo1g	UTSW	11	6515988	missense	probably damaging	1.00
R1809:Myo1g	UTSW	11	6512283	missense	probably benign	0.02
R1957:Myo1g	UTSW	11	6512159	critical splice donor site	probably null
R1978:Myo1g	UTSW	11	6520829	missense	possibly damaging	0.53
R2212:Myo1g	UTSW	11	6517870	missense	possibly damaging	0.88
R2438:Myo1g	UTSW	11	6511542	missense	probably damaging	1.00
R2566:Myo1g	UTSW	11	6512539	critical splice acceptor site	probably null
R3158:Myo1g	UTSW	11	6514527	missense	possibly damaging	0.62
R3159:Myo1g	UTSW	11	6514527	missense	possibly damaging	0.62
R3413:Myo1g	UTSW	11	6517870	missense	possibly damaging	0.88
R3816:Myo1g	UTSW	11	6510926	missense	probably benign	0.02
R3872:Myo1g	UTSW	11	6514886	missense	possibly damaging	0.94
R3946:Myo1g	UTSW	11	6520760	missense	possibly damaging	0.89
R4551:Myo1g	UTSW	11	6517874	missense	probably damaging	1.00
R4625:Myo1g	UTSW	11	6512240	missense	probably damaging	1.00
R4630:Myo1g	UTSW	11	6519047	missense	probably damaging	1.00
R4700:Myo1g	UTSW	11	6516785	unclassified	probably null
R4713:Myo1g	UTSW	11	6516080	missense	probably null	1.00
R4964:Myo1g	UTSW	11	6515976	missense	probably damaging	1.00
R5183:Myo1g	UTSW	11	6508243	missense	probably damaging	1.00
R5191:Myo1g	UTSW	11	6515105	missense	probably benign
R5192:Myo1g	UTSW	11	6514816	missense	probably damaging	1.00
R5726:Myo1g	UTSW	11	6509420	missense	probably benign	0.06
R5841:Myo1g	UTSW	11	6507000	missense	probably benign	0.05
R5942:Myo1g	UTSW	11	6514888	missense	probably damaging	1.00
R6225:Myo1g	UTSW	11	6519168	missense	probably damaging	1.00
R6517:Myo1g	UTSW	11	6512509	missense	probably damaging	0.99
R6563:Myo1g	UTSW	11	6517146	missense	possibly damaging	0.91
R7214:Myo1g	UTSW	11	6511055	missense	probably damaging	1.00
R7258:Myo1g	UTSW	11	6509416	missense	possibly damaging	0.92
R7265:Myo1g	UTSW	11	6510933	missense	possibly damaging	0.92
R7750:Myo1g	UTSW	11	6514849	missense	probably damaging	1.00
X0017:Myo1g	UTSW	11	6516077	critical splice donor site	probably null
X0061:Myo1g	UTSW	11	6517967	missense	probably damaging	1.00
Z1176:Myo1g	UTSW	11	6519045	missense	probably damaging	1.00
Z1177:Myo1g	UTSW	11	6517935	missense	probably damaging	1.00

Posted On

2015-04-16