Incidental Mutation 'IGL00949:Or2w4'
ID 28875
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2w4
Ensembl Gene ENSMUSG00000051258
Gene Name olfactory receptor family 2 subfamily W member 4
Synonyms Olfr1363-ps1, Olfr1362, GA_x6K02T2QHY8-11617756-11618682, GA_x6K02T2QHY8-11628399-11628868, MOR256-8
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # IGL00949
Quality Score
Status
Chromosome 13
Chromosomal Location 21795190-21796174 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21795521 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 206 (I206N)
Ref Sequence ENSEMBL: ENSMUSP00000061660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051874]
AlphaFold Q5SZZ8
Predicted Effect probably damaging
Transcript: ENSMUST00000051874
AA Change: I206N

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000061660
Gene: ENSMUSG00000051258
AA Change: I206N

DomainStartEndE-ValueType
Pfam:7tm_4 32 307 3.5e-51 PFAM
Pfam:7tm_1 41 290 9e-24 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl4 A G X: 141,126,325 (GRCm39) C303R probably damaging Het
Als2 C T 1: 59,254,731 (GRCm39) G209S probably damaging Het
Ankrd11 T C 8: 123,635,467 (GRCm39) T56A possibly damaging Het
Arnt T A 3: 95,394,579 (GRCm39) I381N probably damaging Het
Atp13a1 T C 8: 70,252,653 (GRCm39) probably benign Het
Cd180 A T 13: 102,830,268 (GRCm39) T21S possibly damaging Het
Cdc27 T C 11: 104,420,229 (GRCm39) Y138C probably damaging Het
Dhx16 A G 17: 36,198,826 (GRCm39) T753A probably benign Het
Dnah1 A G 14: 31,029,047 (GRCm39) M561T probably benign Het
Dsc3 C A 18: 20,118,688 (GRCm39) G259C probably null Het
Enox2 A T X: 48,129,484 (GRCm39) D346E probably benign Het
Exoc3l T C 8: 106,017,130 (GRCm39) E619G probably benign Het
Exosc9 T C 3: 36,617,415 (GRCm39) probably benign Het
Gmpr2 C T 14: 55,914,207 (GRCm39) probably benign Het
Golga1 T C 2: 38,931,267 (GRCm39) E289G probably damaging Het
H3c1 G A 13: 23,946,014 (GRCm39) T108I probably damaging Het
Jmy A G 13: 93,590,510 (GRCm39) V531A probably damaging Het
Lamp2 T C X: 37,524,350 (GRCm39) N156S probably benign Het
Lrrn1 C A 6: 107,546,261 (GRCm39) N686K probably benign Het
Lyst T C 13: 13,810,070 (GRCm39) V580A possibly damaging Het
Ms4a8a C A 19: 11,056,808 (GRCm39) L91F probably benign Het
Naip2 A G 13: 100,298,099 (GRCm39) F646L probably damaging Het
Npat T C 9: 53,474,662 (GRCm39) V818A probably benign Het
Padi3 C A 4: 140,516,254 (GRCm39) R542L possibly damaging Het
Pid1 A G 1: 84,016,227 (GRCm39) V46A probably damaging Het
Pld5 A T 1: 175,803,039 (GRCm39) C409S probably damaging Het
Plet1 A G 9: 50,410,523 (GRCm39) T105A possibly damaging Het
Polrmt T C 10: 79,573,431 (GRCm39) probably null Het
Pp2d1 T C 17: 53,822,667 (GRCm39) N133S probably benign Het
Prpf40b G T 15: 99,204,419 (GRCm39) V228L probably benign Het
Ptgfrn A T 3: 100,980,161 (GRCm39) M393K probably benign Het
Slc9a1 C T 4: 133,143,762 (GRCm39) T416I probably benign Het
Slc9c1 T C 16: 45,413,721 (GRCm39) S950P probably benign Het
Slitrk1 A T 14: 109,149,241 (GRCm39) V490D probably damaging Het
Th T C 7: 142,450,763 (GRCm39) Y131C probably benign Het
Tlr6 A G 5: 65,110,855 (GRCm39) L684P probably damaging Het
Tpm3 A G 3: 89,997,165 (GRCm39) E234G probably damaging Het
Tti1 A G 2: 157,824,319 (GRCm39) Y1045H probably benign Het
Txnl4b T A 8: 110,295,707 (GRCm39) V37D probably benign Het
Ufl1 A T 4: 25,275,822 (GRCm39) F194I probably damaging Het
Usp13 G A 3: 32,940,726 (GRCm39) E412K possibly damaging Het
Usp46 A T 5: 74,163,903 (GRCm39) L251Q possibly damaging Het
Other mutations in Or2w4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R1458:Or2w4 UTSW 13 21,795,992 (GRCm39) missense probably benign 0.37
R1587:Or2w4 UTSW 13 21,796,083 (GRCm39) missense probably benign 0.01
R1588:Or2w4 UTSW 13 21,796,083 (GRCm39) missense probably benign 0.01
R1607:Or2w4 UTSW 13 21,795,934 (GRCm39) missense probably benign 0.04
R1708:Or2w4 UTSW 13 21,795,240 (GRCm39) missense probably damaging 0.98
R4633:Or2w4 UTSW 13 21,795,398 (GRCm39) missense probably damaging 0.99
R6223:Or2w4 UTSW 13 21,795,536 (GRCm39) missense probably benign
R6229:Or2w4 UTSW 13 21,795,819 (GRCm39) missense probably benign
R7140:Or2w4 UTSW 13 21,795,297 (GRCm39) missense possibly damaging 0.87
R8385:Or2w4 UTSW 13 21,795,522 (GRCm39) missense probably benign 0.12
R9433:Or2w4 UTSW 13 21,795,224 (GRCm39) missense probably benign 0.04
R9654:Or2w4 UTSW 13 21,795,915 (GRCm39) missense possibly damaging 0.93
R9744:Or2w4 UTSW 13 21,795,827 (GRCm39) missense possibly damaging 0.87
Posted On 2013-04-17