Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02334:Irf3'

288811

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Irf3

Ensembl Gene

ENSMUSG00000003184

Gene Name

interferon regulatory factor 3

Synonyms

IRF-3, C920001K05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02334

Quality Score

Status

Chromosome

Chromosomal Location

44647072-44652272 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 44648134 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148251 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003284] [ENSMUST00000003290] [ENSMUST00000085383] [ENSMUST00000107834] [ENSMUST00000207128] [ENSMUST00000209066] [ENSMUST00000207443] [ENSMUST00000207755] [ENSMUST00000207521] [ENSMUST00000207342] [ENSMUST00000211735]

AlphaFold

P70671

Predicted Effect

probably benign
Transcript: ENSMUST00000003284

SMART Domains

Protein: ENSMUSP00000003284
Gene: ENSMUSG00000003184

Domain	Start	End	E-Value	Type
IRF	1	112	6.92e-50	SMART
IRF-3	195	373	4.87e-73	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000003290

SMART Domains

Protein: ENSMUSP00000003290
Gene: ENSMUSG00000003190

Domain	Start	End	E-Value	Type
low complexity region	47	61	N/A	INTRINSIC
low complexity region	123	139	N/A	INTRINSIC
low complexity region	170	197	N/A	INTRINSIC
SCOP:d1maz__	227	243	4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000085383

SMART Domains

Protein: ENSMUSP00000082501
Gene: ENSMUSG00000038406

Domain	Start	End	E-Value	Type
low complexity region	12	27	N/A	INTRINSIC
low complexity region	59	78	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
low complexity region	185	224	N/A	INTRINSIC
coiled coil region	269	295	N/A	INTRINSIC
low complexity region	367	379	N/A	INTRINSIC
low complexity region	382	396	N/A	INTRINSIC
low complexity region	411	435	N/A	INTRINSIC
low complexity region	488	511	N/A	INTRINSIC
low complexity region	534	618	N/A	INTRINSIC
low complexity region	631	641	N/A	INTRINSIC
low complexity region	669	685	N/A	INTRINSIC
low complexity region	703	726	N/A	INTRINSIC
low complexity region	730	739	N/A	INTRINSIC
low complexity region	752	775	N/A	INTRINSIC
Blast:IG_like	776	833	6e-6	BLAST
low complexity region	843	873	N/A	INTRINSIC
low complexity region	876	888	N/A	INTRINSIC
low complexity region	917	937	N/A	INTRINSIC
coiled coil region	963	983	N/A	INTRINSIC
low complexity region	1025	1037	N/A	INTRINSIC
low complexity region	1098	1128	N/A	INTRINSIC
low complexity region	1136	1146	N/A	INTRINSIC
Blast:IG_like	1151	1194	2e-16	BLAST
low complexity region	1225	1256	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107834

SMART Domains

Protein: ENSMUSP00000103465
Gene: ENSMUSG00000003184

Domain	Start	End	E-Value	Type
IRF	1	112	6.92e-50	SMART
IRF-3	195	373	4.87e-73	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150613

Predicted Effect

probably benign
Transcript: ENSMUST00000207128

Predicted Effect

probably benign
Transcript: ENSMUST00000207129

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209006

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207476

Predicted Effect

probably benign
Transcript: ENSMUST00000209066

Predicted Effect

probably benign
Transcript: ENSMUST00000207443

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208128

Predicted Effect

probably benign
Transcript: ENSMUST00000207755

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208767

Predicted Effect

probably benign
Transcript: ENSMUST00000207521

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207555

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208143

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208906

Predicted Effect

probably benign
Transcript: ENSMUST00000208958

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207213

Predicted Effect

probably benign
Transcript: ENSMUST00000207342

Predicted Effect

probably benign
Transcript: ENSMUST00000211735

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd46	A	G	15: 36,486,079 (GRCm39)	V58A	possibly damaging	Het
Dhx16	A	G	17: 36,194,949 (GRCm39)	E492G	probably damaging	Het
Dock1	T	C	7: 134,747,294 (GRCm39)	M1535T	probably damaging	Het
Evpl	G	T	11: 116,121,850 (GRCm39)	S344*	probably null	Het
F2	A	T	2: 91,463,439 (GRCm39)	H148Q	probably benign	Het
Fam83e	A	T	7: 45,373,345 (GRCm39)	H237L	probably benign	Het
Fscn3	A	T	6: 28,428,153 (GRCm39)		probably null	Het
Gpr162	C	A	6: 124,838,123 (GRCm39)	G176C	probably damaging	Het
Icam5	A	G	9: 20,946,505 (GRCm39)	D376G	possibly damaging	Het
Ift172	T	C	5: 31,440,402 (GRCm39)	K295R	probably benign	Het
Itga2	A	T	13: 115,001,845 (GRCm39)		probably null	Het
Klhl11	A	T	11: 100,354,662 (GRCm39)	D386E	probably damaging	Het
Myh4	G	T	11: 67,136,373 (GRCm39)	G417V	probably damaging	Het
Nlrp3	A	G	11: 59,455,909 (GRCm39)	T902A	probably benign	Het
Or2y17	A	G	11: 49,232,018 (GRCm39)	I220V	probably benign	Het
Or4a72	A	C	2: 89,405,668 (GRCm39)	M134R	possibly damaging	Het
Or9g3	A	T	2: 85,590,503 (GRCm39)	Y72*	probably null	Het
Phf10	T	C	17: 15,174,361 (GRCm39)	Y239C	probably damaging	Het
Pla2g4e	A	G	2: 120,017,717 (GRCm39)	F203S	probably benign	Het
Pramel1	T	C	4: 143,124,096 (GRCm39)	F257S	probably damaging	Het
Prodh2	A	G	7: 30,205,803 (GRCm39)	H213R	probably damaging	Het
Rgs7	C	T	1: 175,016,788 (GRCm39)	D61N	probably damaging	Het
Rhobtb1	T	A	10: 69,121,508 (GRCm39)		probably benign	Het
Sct	C	A	7: 140,858,530 (GRCm39)		probably null	Het
Slc17a9	G	A	2: 180,382,536 (GRCm39)		probably null	Het
Spire1	T	C	18: 67,639,725 (GRCm39)	T263A	probably benign	Het
Trpm1	A	T	7: 63,895,690 (GRCm39)		probably null	Het
Trpm7	G	T	2: 126,649,282 (GRCm39)	N1469K	probably benign	Het
Zfp750	G	T	11: 121,402,837 (GRCm39)	T637K	probably benign	Het
Zswim5	T	C	4: 116,843,841 (GRCm39)	C960R	probably damaging	Het
Zwint	T	A	10: 72,490,815 (GRCm39)		probably null	Het

Other mutations in Irf3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01160:Irf3	APN	7	44,648,220 (GRCm39)	missense	possibly damaging	0.95
IGL01935:Irf3	APN	7	44,650,194 (GRCm39)	missense	probably benign
IGL02428:Irf3	APN	7	44,648,163 (GRCm39)	missense	probably damaging	1.00
IGL02647:Irf3	APN	7	44,649,800 (GRCm39)	missense	probably benign	0.01
R0801:Irf3	UTSW	7	44,650,058 (GRCm39)	unclassified	probably benign
R2128:Irf3	UTSW	7	44,651,168 (GRCm39)	missense	probably damaging	1.00
R2981:Irf3	UTSW	7	44,648,124 (GRCm39)	splice site	probably null
R3746:Irf3	UTSW	7	44,648,297 (GRCm39)	missense	probably damaging	1.00
R5484:Irf3	UTSW	7	44,649,382 (GRCm39)	missense	probably damaging	1.00
R8331:Irf3	UTSW	7	44,650,383 (GRCm39)	missense	probably damaging	1.00
R8692:Irf3	UTSW	7	44,649,889 (GRCm39)	nonsense	probably null
R9189:Irf3	UTSW	7	44,650,246 (GRCm39)	missense	possibly damaging	0.51

Posted On

2015-04-16