Incidental Mutation 'IGL00955:Spin1'
ID28883
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Spin1
Ensembl Gene ENSMUSG00000021395
Gene Namespindlin 1
SynonymsSpin
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL00955
Quality Score
Status
Chromosome13
Chromosomal Location51100880-51152546 bp(+) (GRCm38)
Type of Mutationsplice site (6 bp from exon)
DNA Base Change (assembly) T to C at 51144541 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000093473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095797]
Predicted Effect probably null
Transcript: ENSMUST00000095797
SMART Domains Protein: ENSMUSP00000093473
Gene: ENSMUSG00000021395

DomainStartEndE-ValueType
Pfam:Spin-Ssty 54 103 7.3e-30 PFAM
Pfam:Spin-Ssty 133 182 1.2e-26 PFAM
Pfam:Spin-Ssty 214 259 1.2e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223152
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl11 A T 14: 61,311,242 Q167L probably benign Het
Ces3a T A 8: 105,050,570 V175E probably damaging Het
Cherp C T 8: 72,470,194 E140K probably damaging Het
Clpx A T 9: 65,324,270 T546S probably damaging Het
Csgalnact2 A G 6: 118,129,264 L31P probably damaging Het
Cxcr1 A T 1: 74,192,220 F214L probably benign Het
Cyp2c67 T A 19: 39,643,385 T123S possibly damaging Het
Dbt G A 3: 116,546,114 G384S probably benign Het
Dzank1 G A 2: 144,490,174 T414I probably benign Het
Erich3 A G 3: 154,748,519 I641V probably benign Het
Gtf2e1 A T 16: 37,535,920 D83E possibly damaging Het
Hars2 T C 18: 36,789,357 probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnh2 T C 5: 24,324,966 D372G probably damaging Het
Kcnk2 A T 1: 189,243,014 I264N probably damaging Het
Kctd4 A G 14: 75,963,228 D213G probably damaging Het
Lhx9 T C 1: 138,828,680 T323A possibly damaging Het
Lilra6 C A 7: 3,911,404 probably benign Het
Meig1 T C 2: 3,409,274 D63G probably damaging Het
Mov10l1 A G 15: 88,994,989 Y184C probably damaging Het
Mrpl24 T A 3: 87,922,219 L91* probably null Het
Mup11 C T 4: 60,659,550 R175H probably benign Het
Nbea T C 3: 56,005,472 K965E possibly damaging Het
Olfr598 C A 7: 103,329,321 H278Q probably damaging Het
Papss1 G A 3: 131,599,949 E252K probably benign Het
Robo2 A T 16: 74,015,972 L278Q probably damaging Het
Sned1 A T 1: 93,274,403 I638F probably damaging Het
Taar9 T C 10: 24,109,531 T2A probably benign Het
Tbc1d8b T C X: 139,725,880 probably null Het
Other mutations in Spin1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Spin1 APN 13 51123296 splice site probably benign
IGL03366:Spin1 APN 13 51127937 missense probably benign 0.03
R0050:Spin1 UTSW 13 51150418 utr 3 prime probably benign
R0139:Spin1 UTSW 13 51149012 missense probably benign 0.01
R0745:Spin1 UTSW 13 51139515 missense probably damaging 0.96
R1394:Spin1 UTSW 13 51144481 missense probably damaging 1.00
R1674:Spin1 UTSW 13 51149099 missense probably damaging 1.00
R1980:Spin1 UTSW 13 51144470 missense probably damaging 1.00
R2070:Spin1 UTSW 13 51144537 critical splice donor site probably null
R5326:Spin1 UTSW 13 51139527 missense probably damaging 1.00
R5741:Spin1 UTSW 13 51149135 missense possibly damaging 0.81
R6030:Spin1 UTSW 13 51139516 nonsense probably null
R6030:Spin1 UTSW 13 51139516 nonsense probably null
R6182:Spin1 UTSW 13 51144338 missense probably benign
R7423:Spin1 UTSW 13 51123290 critical splice donor site probably null
R7555:Spin1 UTSW 13 51149049 missense probably benign 0.02
Posted On2013-04-17