Incidental Mutation 'IGL00969:Gpr137b'
| ID |
28890 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr137b
|
| Ensembl Gene |
ENSMUSG00000021306 |
| Gene Name |
G protein-coupled receptor 137B |
| Synonyms |
Tm7sf1, C80741, 2310041G17Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00969
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
13532205-13568599 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 13539650 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Stop codon
at position 258
(W258*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152434
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021738]
[ENSMUST00000220628]
[ENSMUST00000222958]
[ENSMUST00000223093]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000021738
AA Change: W258*
|
| SMART Domains |
Protein: ENSMUSP00000021738
Gene: ENSMUSG00000021306
AA Change: W258*
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:G_alpha
|
19 |
64 |
9e-7 |
BLAST |
|
Blast:G_alpha
|
80 |
264 |
2e-22 |
BLAST |
|
transmembrane domain
|
276 |
298 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000220628
AA Change: W258*
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221340
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221498
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222482
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222958
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000223093
AA Change: W258*
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap9 |
G |
A |
5: 4,051,550 (GRCm39) |
S1439N |
probably benign |
Het |
| Bcl9l |
A |
G |
9: 44,419,539 (GRCm39) |
T1069A |
possibly damaging |
Het |
| Btaf1 |
T |
G |
19: 36,988,652 (GRCm39) |
|
probably benign |
Het |
| Cdc40 |
A |
T |
10: 40,719,124 (GRCm39) |
V335E |
probably damaging |
Het |
| Cenpj |
A |
T |
14: 56,802,420 (GRCm39) |
N48K |
possibly damaging |
Het |
| Cfh |
A |
G |
1: 140,016,420 (GRCm39) |
W635R |
probably damaging |
Het |
| Clca3a1 |
A |
G |
3: 144,714,719 (GRCm39) |
S633P |
possibly damaging |
Het |
| Cnot6 |
T |
C |
11: 49,575,947 (GRCm39) |
M176V |
probably benign |
Het |
| Cryz |
G |
T |
3: 154,324,163 (GRCm39) |
E51* |
probably null |
Het |
| Dcc |
A |
G |
18: 71,589,954 (GRCm39) |
Y681H |
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,045,792 (GRCm39) |
N2412K |
probably benign |
Het |
| Hnf1b |
A |
G |
11: 83,773,526 (GRCm39) |
T242A |
probably benign |
Het |
| Hsd11b1 |
A |
T |
1: 192,905,952 (GRCm39) |
C213* |
probably null |
Het |
| Igsf11 |
A |
T |
16: 38,829,279 (GRCm39) |
T117S |
probably damaging |
Het |
| Inpp5b |
T |
C |
4: 124,677,787 (GRCm39) |
Y416H |
probably damaging |
Het |
| Kcnq3 |
C |
A |
15: 65,876,575 (GRCm39) |
V523F |
probably damaging |
Het |
| Krtap9-5 |
T |
C |
11: 99,839,291 (GRCm39) |
|
probably benign |
Het |
| Lrig3 |
T |
C |
10: 125,832,984 (GRCm39) |
L286S |
probably damaging |
Het |
| Myo18b |
C |
T |
5: 113,022,873 (GRCm39) |
|
probably benign |
Het |
| Nup58 |
A |
G |
14: 60,466,365 (GRCm39) |
|
probably benign |
Het |
| Or51b6b |
T |
A |
7: 103,310,274 (GRCm39) |
Y61F |
probably damaging |
Het |
| Or5b94 |
T |
C |
19: 12,651,605 (GRCm39) |
L12P |
probably damaging |
Het |
| Or5h18 |
A |
G |
16: 58,847,994 (GRCm39) |
I92T |
possibly damaging |
Het |
| Or8k16 |
G |
A |
2: 85,520,007 (GRCm39) |
C78Y |
probably benign |
Het |
| Pyroxd2 |
T |
C |
19: 42,719,877 (GRCm39) |
D443G |
possibly damaging |
Het |
| Ttc28 |
A |
G |
5: 111,373,606 (GRCm39) |
D1014G |
probably benign |
Het |
| Tubgcp5 |
T |
A |
7: 55,456,343 (GRCm39) |
S312T |
possibly damaging |
Het |
| Uckl1 |
T |
C |
2: 181,211,410 (GRCm39) |
D473G |
probably benign |
Het |
| Vmn2r76 |
G |
T |
7: 85,877,925 (GRCm39) |
H491N |
probably benign |
Het |
| Wwc2 |
G |
A |
8: 48,299,193 (GRCm39) |
R1039W |
unknown |
Het |
| Zc3h14 |
T |
A |
12: 98,725,102 (GRCm39) |
S255T |
probably benign |
Het |
| Zfp369 |
T |
C |
13: 65,445,074 (GRCm39) |
V739A |
probably benign |
Het |
| Zfyve21 |
A |
G |
12: 111,791,368 (GRCm39) |
|
probably benign |
Het |
| Znhit6 |
A |
G |
3: 145,300,351 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Gpr137b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Gpr137b
|
APN |
13 |
13,549,000 (GRCm39) |
splice site |
probably benign |
|
|
R0276:Gpr137b
|
UTSW |
13 |
13,542,160 (GRCm39) |
splice site |
probably benign |
|
|
R1102:Gpr137b
|
UTSW |
13 |
13,539,616 (GRCm39) |
splice site |
probably benign |
|
|
R4012:Gpr137b
|
UTSW |
13 |
13,533,947 (GRCm39) |
missense |
probably benign |
|
|
R4712:Gpr137b
|
UTSW |
13 |
13,533,974 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5892:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R6269:Gpr137b
|
UTSW |
13 |
13,538,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6841:Gpr137b
|
UTSW |
13 |
13,538,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7165:Gpr137b
|
UTSW |
13 |
13,542,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7772:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R7996:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R7997:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R7998:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R7999:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8049:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8093:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8108:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8109:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8111:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8153:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8154:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8156:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8358:Gpr137b
|
UTSW |
13 |
13,533,929 (GRCm39) |
missense |
probably benign |
|
|
R8686:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8687:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8688:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
R8921:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
| Posted On |
2013-04-17 |
Incidental Mutation