Incidental Mutation 'IGL02337:Gna15'
ID288900
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gna15
Ensembl Gene ENSMUSG00000034792
Gene Nameguanine nucleotide binding protein, alpha 15
SynonymsGalpha15, G[a]15
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.184) question?
Stock #IGL02337
Quality Score
Status
Chromosome10
Chromosomal Location81502306-81524225 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 81514410 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 53 (S53G)
Ref Sequence ENSEMBL: ENSMUSP00000049175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043709]
Predicted Effect probably damaging
Transcript: ENSMUST00000043709
AA Change: S53G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049175
Gene: ENSMUSG00000034792
AA Change: S53G

DomainStartEndE-ValueType
G_alpha 22 373 1.22e-188 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150586
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit normal hematopoiesis and normal response to inflammatory challenges. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A G 15: 102,339,227 V403A probably benign Het
Afm A G 5: 90,547,911 T426A probably benign Het
Atp8a2 T C 14: 59,998,002 D697G probably benign Het
Barhl1 G T 2: 28,911,419 S204R probably damaging Het
Ceacam11 T A 7: 17,973,625 S111R probably benign Het
Cenpe A G 3: 135,220,276 probably benign Het
Cnot11 G A 1: 39,544,883 probably benign Het
Ctc1 A G 11: 69,026,131 T284A probably damaging Het
Ephb3 A G 16: 21,221,503 probably null Het
Fsip1 T A 2: 118,251,714 K80* probably null Het
Gaa G T 11: 119,277,603 G220C probably damaging Het
Hfm1 A T 5: 106,904,267 M321K possibly damaging Het
Hgfac C A 5: 35,042,378 T68K probably benign Het
Hmgxb4 C T 8: 74,999,631 R35W probably damaging Het
Itfg2 T C 6: 128,413,570 D184G probably benign Het
Kirrel G A 3: 87,089,212 T360I possibly damaging Het
Lrp1 T C 10: 127,576,887 Q1240R possibly damaging Het
Lrrk1 G T 7: 66,279,416 T1156N possibly damaging Het
Olfm1 A G 2: 28,229,685 Y429C probably damaging Het
Olfr1093 T A 2: 86,786,174 M148K probably damaging Het
Olfr1283 T G 2: 111,369,151 V173G probably benign Het
Pafah1b2 C T 9: 45,972,989 V122I probably benign Het
Pdcd1 T C 1: 94,040,857 T151A probably benign Het
Pkd1l1 T C 11: 8,942,079 S697G probably damaging Het
Rgs12 T A 5: 35,020,353 F96I probably damaging Het
Sptbn4 T C 7: 27,428,247 D176G probably benign Het
Tarbp2 C A 15: 102,521,993 Q148K probably damaging Het
Txk T C 5: 72,707,546 R329G possibly damaging Het
Unc79 T A 12: 103,156,446 probably benign Het
Vmn1r73 C A 7: 11,756,713 P153T possibly damaging Het
Zeb2 G A 2: 44,997,230 T605I probably damaging Het
Zfp654 A G 16: 64,785,149 S897P probably benign Het
Other mutations in Gna15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03346:Gna15 APN 10 81503045 missense probably damaging 0.99
R0062:Gna15 UTSW 10 81512405 splice site probably null
R0062:Gna15 UTSW 10 81512405 splice site probably null
R0464:Gna15 UTSW 10 81512504 missense probably benign 0.15
R0732:Gna15 UTSW 10 81512556 missense probably damaging 0.97
R1529:Gna15 UTSW 10 81509342 missense probably damaging 1.00
R1768:Gna15 UTSW 10 81512120 missense probably damaging 1.00
R2151:Gna15 UTSW 10 81502904 missense probably damaging 1.00
R2153:Gna15 UTSW 10 81502904 missense probably damaging 1.00
R5575:Gna15 UTSW 10 81523873 missense probably damaging 1.00
R5750:Gna15 UTSW 10 81509396 nonsense probably null
R5790:Gna15 UTSW 10 81509384 missense probably damaging 1.00
R6123:Gna15 UTSW 10 81509344 missense probably damaging 1.00
R6222:Gna15 UTSW 10 81512046 missense probably damaging 1.00
R6750:Gna15 UTSW 10 81514283 missense probably benign
R7138:Gna15 UTSW 10 81508047 missense probably damaging 1.00
R7426:Gna15 UTSW 10 81502997 missense probably benign 0.03
R7542:Gna15 UTSW 10 81514302 missense probably damaging 1.00
R7802:Gna15 UTSW 10 81514341 missense probably benign 0.28
R7942:Gna15 UTSW 10 81523911 missense probably damaging 0.98
Posted On2015-04-16