Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00970:Vmn1r200'

28892

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r200

Ensembl Gene

ENSMUSG00000101073

Gene Name

vomeronasal 1 receptor 200

Synonyms

V1rh3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.144) question?

Stock #

IGL00970

Quality Score

Status

Chromosome

Chromosomal Location

22579199-22580137 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22579893 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 232 (Q232L)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074324] [ENSMUST00000226157] [ENSMUST00000227326] [ENSMUST00000228726]

AlphaFold

Q8R281

Predicted Effect

probably damaging
Transcript: ENSMUST00000074324
AA Change: Q232L

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000073934
Gene: ENSMUSG00000101073
AA Change: Q232L

Domain	Start	End	E-Value	Type
Pfam:V1R	24	307	5.5e-36	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000091731
AA Change: Q232L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000089325
Gene: ENSMUSG00000069291
AA Change: Q232L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	2	291	1.3e-8	PFAM
Pfam:V1R	34	297	3.8e-37	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226157
AA Change: Q232L

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226901

Predicted Effect

probably damaging
Transcript: ENSMUST00000227326
AA Change: Q223L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228726
AA Change: Q232L

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	T	A	18: 59,144,149 (GRCm39)	N910K	possibly damaging	Het
Atp8b5	A	G	4: 43,311,938 (GRCm39)	T184A	probably benign	Het
Cabp7	T	C	11: 4,688,931 (GRCm39)	I180V	probably benign	Het
Casp8ap2	A	G	4: 32,646,182 (GRCm39)	T1752A	probably benign	Het
Dgkb	T	C	12: 38,240,082 (GRCm39)	L453P	probably damaging	Het
Disp2	A	C	2: 118,622,274 (GRCm39)	D1002A	probably damaging	Het
Eif3c	G	A	7: 126,158,180 (GRCm39)	P259S	probably benign	Het
Eif4a3l1	A	G	6: 136,306,109 (GRCm39)	D169G	probably damaging	Het
Fam227b	A	T	2: 125,968,980 (GRCm39)	D31E	probably benign	Het
Farp2	T	C	1: 93,488,049 (GRCm39)	V92A	probably benign	Het
Fhod1	C	A	8: 106,058,734 (GRCm39)	V745L	possibly damaging	Het
Gprin3	T	C	6: 59,330,822 (GRCm39)	E495G	possibly damaging	Het
Grm5	T	C	7: 87,453,104 (GRCm39)	I247T	probably damaging	Het
Herc2	T	C	7: 55,830,812 (GRCm39)		probably benign	Het
Hoatz	T	A	9: 50,994,886 (GRCm39)	K148*	probably null	Het
Hspg2	C	A	4: 137,269,901 (GRCm39)	Q2311K	probably benign	Het
Krt26	T	C	11: 99,222,107 (GRCm39)	Y400C	probably benign	Het
Lct	A	T	1: 128,231,805 (GRCm39)	D681E	probably damaging	Het
Lgalsl	G	T	11: 20,776,493 (GRCm39)	P133Q	probably benign	Het
Man2b2	C	T	5: 36,973,487 (GRCm39)	W76*	probably null	Het
Mylk4	T	C	13: 32,899,905 (GRCm39)	E326G	probably damaging	Het
Odam	T	G	5: 88,034,467 (GRCm39)		probably benign	Het
Pabpc4	T	C	4: 123,180,608 (GRCm39)	I110T	probably damaging	Het
Pcdh15	A	T	10: 74,215,172 (GRCm39)	D47V	probably damaging	Het
Plekhg4	C	T	8: 106,105,067 (GRCm39)	R577C	probably benign	Het
Pnpo	C	A	11: 96,834,618 (GRCm39)	C26F	possibly damaging	Het
Polg	T	C	7: 79,101,493 (GRCm39)	I1071M	probably benign	Het
Prr23a2	A	G	9: 98,739,014 (GRCm39)	D124G	probably benign	Het
Rexo1	C	T	10: 80,386,798 (GRCm39)	V87I	probably damaging	Het
Robo2	C	A	16: 73,693,934 (GRCm39)	V1502L	probably benign	Het
Ruvbl2	A	G	7: 45,078,994 (GRCm39)	L50P	possibly damaging	Het
Ryr3	T	C	2: 112,595,021 (GRCm39)	K2534E	probably damaging	Het
Scfd2	T	C	5: 74,691,595 (GRCm39)	H229R	possibly damaging	Het
Sesn3	A	G	9: 14,232,438 (GRCm39)	D237G	probably damaging	Het
Shank1	T	C	7: 44,003,662 (GRCm39)	S1785P	possibly damaging	Het
Slc11a1	A	G	1: 74,419,821 (GRCm39)	T165A	probably damaging	Het
Star	G	A	8: 26,302,894 (GRCm39)		probably null	Het
Trpc6	A	T	9: 8,653,152 (GRCm39)	N575Y	probably damaging	Het
Unc5d	T	C	8: 29,186,456 (GRCm39)	T598A	probably benign	Het
Wdr31	T	C	4: 62,375,757 (GRCm39)	T233A	probably damaging	Het
Zzef1	G	A	11: 72,806,071 (GRCm39)	R2669Q	probably benign	Het

Other mutations in Vmn1r200

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01123:Vmn1r200	APN	13	22,579,571 (GRCm39)	missense	probably benign	0.01
IGL01943:Vmn1r200	APN	13	22,580,097 (GRCm39)	missense	possibly damaging	0.77
IGL02691:Vmn1r200	APN	13	22,579,428 (GRCm39)	missense	probably damaging	1.00
R0491:Vmn1r200	UTSW	13	22,579,361 (GRCm39)	missense	probably benign	0.00
R0507:Vmn1r200	UTSW	13	22,579,718 (GRCm39)	missense	probably benign	0.00
R0530:Vmn1r200	UTSW	13	22,579,667 (GRCm39)	missense	probably damaging	1.00
R1033:Vmn1r200	UTSW	13	22,580,060 (GRCm39)	missense	probably damaging	1.00
R1054:Vmn1r200	UTSW	13	22,579,624 (GRCm39)	missense	probably damaging	1.00
R1714:Vmn1r200	UTSW	13	22,579,640 (GRCm39)	missense	possibly damaging	0.96
R1920:Vmn1r200	UTSW	13	22,579,663 (GRCm39)	missense	probably damaging	1.00
R2118:Vmn1r200	UTSW	13	22,579,353 (GRCm39)	missense	probably damaging	1.00
R3784:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R4827:Vmn1r200	UTSW	13	22,579,265 (GRCm39)	missense	probably benign	0.00
R5285:Vmn1r200	UTSW	13	22,579,457 (GRCm39)	missense	possibly damaging	0.51
R5299:Vmn1r200	UTSW	13	22,579,945 (GRCm39)	nonsense	probably null
R6127:Vmn1r200	UTSW	13	22,579,373 (GRCm39)	missense	probably benign	0.07
R7167:Vmn1r200	UTSW	13	22,579,487 (GRCm39)	missense	possibly damaging	0.91
R7854:Vmn1r200	UTSW	13	22,580,009 (GRCm39)	missense	probably benign	0.08
R7977:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R7987:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R8061:Vmn1r200	UTSW	13	22,579,453 (GRCm39)	nonsense	probably null
R8208:Vmn1r200	UTSW	13	22,579,470 (GRCm39)	missense	probably damaging	0.99
R9481:Vmn1r200	UTSW	13	22,579,911 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-04-17