Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02340:Vmn1r115'

289030

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02340

Quality Score

Status

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20844528 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 153 (H153L)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169374
AA Change: H153L

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: H153L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt2	T	A	7: 27,629,399	I182N	probably damaging	Het
Alpk3	A	G	7: 81,078,507	T462A	probably benign	Het
Amz1	A	G	5: 140,752,259	R425G	probably damaging	Het
Aoc2	A	G	11: 101,326,375	E428G	probably damaging	Het
Car4	C	T	11: 84,965,767	P294S	probably damaging	Het
Chchd6	A	T	6: 89,419,780	H216Q	probably damaging	Het
Chl1	A	G	6: 103,698,125	Y591C	probably damaging	Het
Cln8	T	C	8: 14,895,178	L164S	probably damaging	Het
Dscaml1	T	C	9: 45,670,176	I431T	possibly damaging	Het
Fam234b	T	C	6: 135,231,661	L524P	probably damaging	Het
Fmo1	T	C	1: 162,832,990	N410S	probably benign	Het
Ftsj3	G	A	11: 106,253,146	R251*	probably null	Het
Greb1l	A	T	18: 10,515,200	D555V	probably damaging	Het
Hcar1	G	T	5: 123,879,072	H185Q	probably damaging	Het
Kcnj12	G	A	11: 61,069,493	V206I	probably benign	Het
Lamc3	G	A	2: 31,918,457	G742S	probably damaging	Het
Lipg	T	C	18: 74,960,875		probably null	Het
Ltbp2	A	G	12: 84,792,955		probably null	Het
Mcm3ap	T	G	10: 76,496,552	Y1234*	probably null	Het
Myh6	T	A	14: 54,957,155	D719V	possibly damaging	Het
Myo9b	A	G	8: 71,291,045	N250S	probably damaging	Het
Notch2	G	A	3: 98,147,336	W2438*	probably null	Het
Nphp1	G	A	2: 127,780,067	Q47*	probably null	Het
Nptx2	T	C	5: 144,556,246	L381P	probably damaging	Het
Nrxn3	A	G	12: 90,204,628	N911S	possibly damaging	Het
Olfr1176	T	C	2: 88,339,562		probably benign	Het
Olfr418	A	T	1: 173,270,405	I77F	probably benign	Het
P4ha1	T	A	10: 59,352,201	F260Y	probably benign	Het
Pitpnm2	T	C	5: 124,130,613	D504G	probably damaging	Het
Prss54	A	G	8: 95,565,609	V114A	probably benign	Het
Ptprc	G	A	1: 138,071,219	T1031M	probably damaging	Het
Rtf2	T	C	2: 172,468,591		probably benign	Het
Ryr3	A	G	2: 112,947,004		probably benign	Het
Slc14a2	C	T	18: 78,163,126	E492K	probably damaging	Het
Slc9a3r1	A	G	11: 115,180,032	E270G	probably benign	Het
Stab1	G	T	14: 31,140,410	N2322K	probably damaging	Het
Thsd7b	A	G	1: 130,159,632	N1162S	probably benign	Het
Tmprss11b	T	C	5: 86,662,231	I297V	probably benign	Het
Tnn	T	C	1: 160,145,205	N276D	probably benign	Het
Trhde	A	T	10: 114,592,213		probably benign	Het
Vmn1r203	T	A	13: 22,524,827	C259*	probably null	Het
Xpot	T	A	10: 121,615,204	E97V	probably damaging	Het
Zbtb2	T	C	10: 4,368,712	D438G	probably damaging	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20844630	missense	possibly damaging	0.87
R5986:Vmn1r115	UTSW	7	20844522	missense	probably benign	0.44
R6180:Vmn1r115	UTSW	7	20844715	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Posted On

2015-04-16