Incidental Mutation 'IGL02341:Myo19'
ID 289115
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myo19
Ensembl Gene ENSMUSG00000020527
Gene Name myosin XIX
Synonyms Myohd1, 1110055A02Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL02341
Quality Score
Status
Chromosome 11
Chromosomal Location 84770996-84802052 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 84778871 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000091502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020837] [ENSMUST00000093969]
AlphaFold Q5SV80
Predicted Effect probably benign
Transcript: ENSMUST00000020837
SMART Domains Protein: ENSMUSP00000020837
Gene: ENSMUSG00000020527

DomainStartEndE-ValueType
MYSc 29 205 2.18e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000093969
SMART Domains Protein: ENSMUSP00000091502
Gene: ENSMUSG00000020527

DomainStartEndE-ValueType
MYSc 29 759 4.07e-219 SMART
IQ 760 782 1.74e1 SMART
IQ 783 804 1.97e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124152
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141173
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141705
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid2 C T 15: 96,270,066 (GRCm39) S1393L probably benign Het
Bahcc1 T A 11: 120,163,346 (GRCm39) I548N probably damaging Het
Baiap3 A T 17: 25,467,290 (GRCm39) L405Q possibly damaging Het
Cacna1g T G 11: 94,352,978 (GRCm39) Q349P probably damaging Het
Ccdc30 T C 4: 119,213,978 (GRCm39) T184A possibly damaging Het
Ccdc63 A G 5: 122,251,261 (GRCm39) I383T probably benign Het
Ccnk A G 12: 108,161,989 (GRCm39) E298G unknown Het
Ccnt1 T C 15: 98,444,664 (GRCm39) E223G possibly damaging Het
Clcc1 T A 3: 108,580,699 (GRCm39) L333I possibly damaging Het
Cyp2b10 G A 7: 25,610,667 (GRCm39) R59Q probably benign Het
Cyp3a41b T A 5: 145,510,461 (GRCm39) T138S probably benign Het
Dennd4a C T 9: 64,749,843 (GRCm39) R145* probably null Het
Dnah8 A T 17: 30,966,231 (GRCm39) I2474F probably damaging Het
Dok1 T C 6: 83,010,035 (GRCm39) T25A probably damaging Het
Ears2 G A 7: 121,638,987 (GRCm39) A479V probably benign Het
Erc1 T A 6: 119,571,934 (GRCm39) I981F possibly damaging Het
Gm8730 A G 8: 103,591,775 (GRCm39) noncoding transcript Het
Gm9962 C T 7: 57,037,042 (GRCm39) probably benign Het
Has3 A T 8: 107,600,637 (GRCm39) Y33F probably damaging Het
Hk1 A G 10: 62,120,159 (GRCm39) S607P possibly damaging Het
Hlcs T A 16: 94,031,969 (GRCm39) I612F probably damaging Het
Llgl2 T A 11: 115,741,946 (GRCm39) S663T possibly damaging Het
Lrriq1 T C 10: 103,060,802 (GRCm39) H100R probably benign Het
Lypd8l T C 11: 58,503,656 (GRCm39) S17G possibly damaging Het
Magi2 T A 5: 20,671,201 (GRCm39) I678N probably damaging Het
Megf11 G A 9: 64,451,902 (GRCm39) G109S probably damaging Het
Morc2b A T 17: 33,356,281 (GRCm39) I497K probably damaging Het
Mybpc2 A C 7: 44,164,354 (GRCm39) S404A probably benign Het
Mylip A G 13: 45,544,752 (GRCm39) R59G probably damaging Het
Mylk3 A T 8: 86,078,601 (GRCm39) I501N probably damaging Het
Nat2 A G 8: 67,954,370 (GRCm39) Y160C possibly damaging Het
Nf1 C T 11: 79,455,752 (GRCm39) A2554V probably benign Het
Niban3 A T 8: 72,056,443 (GRCm39) N381I possibly damaging Het
Ninl A T 2: 150,786,525 (GRCm39) C153* probably null Het
Nlrp5 C T 7: 23,103,577 (GRCm39) R15C probably benign Het
Nphp4 A T 4: 152,639,926 (GRCm39) probably benign Het
Obscn C A 11: 59,026,651 (GRCm39) R184L probably benign Het
Or6c202 T A 10: 128,996,302 (GRCm39) I184F probably benign Het
Or6c6c A T 10: 129,541,358 (GRCm39) T204S probably damaging Het
Or6c8 A T 10: 128,915,330 (GRCm39) C167* probably null Het
Phip A T 9: 82,814,936 (GRCm39) V262D probably damaging Het
Ptprg T A 14: 12,154,360 (GRCm38) S694T probably benign Het
Reck T A 4: 43,925,160 (GRCm39) D466E probably damaging Het
Rimbp2 G T 5: 128,878,025 (GRCm39) Y213* probably null Het
Scn2a C T 2: 65,518,721 (GRCm39) T365M probably damaging Het
Scpep1 T A 11: 88,835,314 (GRCm39) T120S probably benign Het
Sp7 T A 15: 102,267,657 (GRCm39) T50S possibly damaging Het
Tbc1d1 A G 5: 64,432,750 (GRCm39) R304G probably damaging Het
Tiam1 A G 16: 89,695,257 (GRCm39) S67P probably damaging Het
Tjp1 G A 7: 64,962,382 (GRCm39) T1185I probably damaging Het
Tspan2 T A 3: 102,672,529 (GRCm39) I178N probably damaging Het
Tusc2 T A 9: 107,442,109 (GRCm39) *103R probably null Het
Uggt1 A T 1: 36,203,600 (GRCm39) *47R probably null Het
Unc13c T A 9: 73,840,492 (GRCm39) I120F possibly damaging Het
Vcpip1 T A 1: 9,795,175 (GRCm39) K1065N possibly damaging Het
Zfp532 C A 18: 65,757,849 (GRCm39) P594Q probably damaging Het
Other mutations in Myo19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Myo19 APN 11 84,800,324 (GRCm39) missense probably benign 0.00
IGL01120:Myo19 APN 11 84,798,104 (GRCm39) missense probably damaging 0.96
IGL01542:Myo19 APN 11 84,800,372 (GRCm39) missense probably damaging 0.96
IGL02708:Myo19 APN 11 84,790,222 (GRCm39) missense possibly damaging 0.89
IGL03223:Myo19 APN 11 84,801,297 (GRCm39) missense possibly damaging 0.57
BB004:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
BB014:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
R0009:Myo19 UTSW 11 84,778,995 (GRCm39) critical splice donor site probably null
R0125:Myo19 UTSW 11 84,779,001 (GRCm39) splice site probably benign
R0142:Myo19 UTSW 11 84,785,429 (GRCm39) missense probably damaging 1.00
R0226:Myo19 UTSW 11 84,788,558 (GRCm39) splice site probably benign
R0230:Myo19 UTSW 11 84,784,159 (GRCm39) missense possibly damaging 0.91
R0482:Myo19 UTSW 11 84,800,245 (GRCm39) missense probably benign 0.00
R1981:Myo19 UTSW 11 84,782,996 (GRCm39) missense possibly damaging 0.46
R2035:Myo19 UTSW 11 84,788,434 (GRCm39) missense probably benign
R2185:Myo19 UTSW 11 84,783,047 (GRCm39) missense probably benign 0.00
R3176:Myo19 UTSW 11 84,783,001 (GRCm39) missense probably benign 0.01
R3276:Myo19 UTSW 11 84,783,001 (GRCm39) missense probably benign 0.01
R3824:Myo19 UTSW 11 84,776,505 (GRCm39) missense probably damaging 0.98
R3914:Myo19 UTSW 11 84,785,429 (GRCm39) missense probably damaging 1.00
R4333:Myo19 UTSW 11 84,799,114 (GRCm39) missense probably benign 0.00
R4335:Myo19 UTSW 11 84,799,114 (GRCm39) missense probably benign 0.00
R4647:Myo19 UTSW 11 84,785,468 (GRCm39) missense probably damaging 1.00
R4968:Myo19 UTSW 11 84,792,328 (GRCm39) missense probably damaging 1.00
R4971:Myo19 UTSW 11 84,783,023 (GRCm39) missense probably damaging 1.00
R5083:Myo19 UTSW 11 84,794,037 (GRCm39) missense possibly damaging 0.60
R5284:Myo19 UTSW 11 84,776,098 (GRCm39) splice site probably null
R5558:Myo19 UTSW 11 84,801,274 (GRCm39) missense probably damaging 1.00
R5739:Myo19 UTSW 11 84,788,450 (GRCm39) missense probably damaging 1.00
R5982:Myo19 UTSW 11 84,790,226 (GRCm39) missense probably damaging 0.97
R6093:Myo19 UTSW 11 84,776,535 (GRCm39) missense probably damaging 1.00
R6444:Myo19 UTSW 11 84,786,134 (GRCm39) missense probably benign
R6657:Myo19 UTSW 11 84,788,022 (GRCm39) missense probably benign
R6945:Myo19 UTSW 11 84,788,386 (GRCm39) missense probably benign 0.06
R7022:Myo19 UTSW 11 84,791,373 (GRCm39) missense probably damaging 0.99
R7058:Myo19 UTSW 11 84,798,194 (GRCm39) missense possibly damaging 0.89
R7150:Myo19 UTSW 11 84,796,439 (GRCm39) missense probably benign
R7155:Myo19 UTSW 11 84,791,412 (GRCm39) missense probably damaging 1.00
R7478:Myo19 UTSW 11 84,776,626 (GRCm39) missense probably benign 0.41
R7486:Myo19 UTSW 11 84,796,463 (GRCm39) missense probably benign
R7833:Myo19 UTSW 11 84,800,093 (GRCm39) missense probably benign
R7921:Myo19 UTSW 11 84,799,064 (GRCm39) missense possibly damaging 0.55
R7923:Myo19 UTSW 11 84,776,536 (GRCm39) missense possibly damaging 0.87
R7927:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
R9105:Myo19 UTSW 11 84,794,029 (GRCm39) missense probably damaging 0.99
R9714:Myo19 UTSW 11 84,773,542 (GRCm39) start codon destroyed probably null 0.18
X0053:Myo19 UTSW 11 84,788,541 (GRCm39) nonsense probably null
Z1176:Myo19 UTSW 11 84,800,176 (GRCm39) frame shift probably null
Z1176:Myo19 UTSW 11 84,776,104 (GRCm39) missense probably benign 0.05
Posted On 2015-04-16