Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02341:Myo19'

289115

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myo19

Ensembl Gene

ENSMUSG00000020527

Gene Name

myosin XIX

Synonyms

Myohd1, 1110055A02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

IGL02341

Quality Score

Status

Chromosome

Chromosomal Location

84880148-84911226 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 84888045 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000091502 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020837] [ENSMUST00000093969]

AlphaFold

Q5SV80

Predicted Effect

probably benign
Transcript: ENSMUST00000020837

SMART Domains

Protein: ENSMUSP00000020837
Gene: ENSMUSG00000020527

Domain	Start	End	E-Value	Type
MYSc	29	205	2.18e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000093969

SMART Domains

Protein: ENSMUSP00000091502
Gene: ENSMUSG00000020527

Domain	Start	End	E-Value	Type
MYSc	29	759	4.07e-219	SMART
IQ	760	782	1.74e1	SMART
IQ	783	804	1.97e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124152

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141173

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141705

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210407C18Rik	T	C	11: 58,612,830	S17G	possibly damaging	Het
Arid2	C	T	15: 96,372,185	S1393L	probably benign	Het
Bahcc1	T	A	11: 120,272,520	I548N	probably damaging	Het
Baiap3	A	T	17: 25,248,316	L405Q	possibly damaging	Het
Cacna1g	T	G	11: 94,462,152	Q349P	probably damaging	Het
Ccdc30	T	C	4: 119,356,781	T184A	possibly damaging	Het
Ccdc63	A	G	5: 122,113,198	I383T	probably benign	Het
Ccnk	A	G	12: 108,195,730	E298G	unknown	Het
Ccnt1	T	C	15: 98,546,783	E223G	possibly damaging	Het
Clcc1	T	A	3: 108,673,383	L333I	possibly damaging	Het
Cyp2b10	G	A	7: 25,911,242	R59Q	probably benign	Het
Cyp3a41b	T	A	5: 145,573,651	T138S	probably benign	Het
Dennd4a	C	T	9: 64,842,561	R145*	probably null	Het
Dnah8	A	T	17: 30,747,257	I2474F	probably damaging	Het
Dok1	T	C	6: 83,033,054	T25A	probably damaging	Het
Ears2	G	A	7: 122,039,764	A479V	probably benign	Het
Erc1	T	A	6: 119,594,973	I981F	possibly damaging	Het
Fam129c	A	T	8: 71,603,799	N381I	possibly damaging	Het
Gm8730	A	G	8: 102,865,143		noncoding transcript	Het
Gm9962	C	T	7: 57,387,294		probably benign	Het
Has3	A	T	8: 106,874,005	Y33F	probably damaging	Het
Hk1	A	G	10: 62,284,380	S607P	possibly damaging	Het
Hlcs	T	A	16: 94,231,110	I612F	probably damaging	Het
Llgl2	T	A	11: 115,851,120	S663T	possibly damaging	Het
Lrriq1	T	C	10: 103,224,941	H100R	probably benign	Het
Magi2	T	A	5: 20,466,203	I678N	probably damaging	Het
Megf11	G	A	9: 64,544,620	G109S	probably damaging	Het
Morc2b	A	T	17: 33,137,307	I497K	probably damaging	Het
Mybpc2	A	C	7: 44,514,930	S404A	probably benign	Het
Mylip	A	G	13: 45,391,276	R59G	probably damaging	Het
Mylk3	A	T	8: 85,351,972	I501N	probably damaging	Het
Nat2	A	G	8: 67,501,718	Y160C	possibly damaging	Het
Nf1	C	T	11: 79,564,926	A2554V	probably benign	Het
Ninl	A	T	2: 150,944,605	C153*	probably null	Het
Nlrp5	C	T	7: 23,404,152	R15C	probably benign	Het
Nphp4	A	T	4: 152,555,469		probably benign	Het
Obscn	C	A	11: 59,135,825	R184L	probably benign	Het
Olfr767	A	T	10: 129,079,461	C167*	probably null	Het
Olfr771	T	A	10: 129,160,433	I184F	probably benign	Het
Olfr804	A	T	10: 129,705,489	T204S	probably damaging	Het
Phip	A	T	9: 82,932,883	V262D	probably damaging	Het
Ptprg	T	A	14: 12,154,360	S694T	probably benign	Het
Reck	T	A	4: 43,925,160	D466E	probably damaging	Het
Rimbp2	G	T	5: 128,800,961	Y213*	probably null	Het
Scn2a	C	T	2: 65,688,377	T365M	probably damaging	Het
Scpep1	T	A	11: 88,944,488	T120S	probably benign	Het
Sp7	T	A	15: 102,359,222	T50S	possibly damaging	Het
Tbc1d1	A	G	5: 64,275,407	R304G	probably damaging	Het
Tiam1	A	G	16: 89,898,369	S67P	probably damaging	Het
Tjp1	G	A	7: 65,312,634	T1185I	probably damaging	Het
Tspan2	T	A	3: 102,765,213	I178N	probably damaging	Het
Tusc2	T	A	9: 107,564,910	*103R	probably null	Het
Uggt1	A	T	1: 36,164,519	*47R	probably null	Het
Unc13c	T	A	9: 73,933,210	I120F	possibly damaging	Het
Vcpip1	T	A	1: 9,724,950	K1065N	possibly damaging	Het
Zfp532	C	A	18: 65,624,778	P594Q	probably damaging	Het

Other mutations in Myo19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00896:Myo19	APN	11	84909498	missense	probably benign	0.00
IGL01120:Myo19	APN	11	84907278	missense	probably damaging	0.96
IGL01542:Myo19	APN	11	84909546	missense	probably damaging	0.96
IGL02708:Myo19	APN	11	84899396	missense	possibly damaging	0.89
IGL03223:Myo19	APN	11	84910471	missense	possibly damaging	0.57
BB004:Myo19	UTSW	11	84900220	missense	probably damaging	1.00
BB014:Myo19	UTSW	11	84900220	missense	probably damaging	1.00
R0009:Myo19	UTSW	11	84888169	critical splice donor site	probably null
R0125:Myo19	UTSW	11	84888175	splice site	probably benign
R0142:Myo19	UTSW	11	84894603	missense	probably damaging	1.00
R0226:Myo19	UTSW	11	84897732	splice site	probably benign
R0230:Myo19	UTSW	11	84893333	missense	possibly damaging	0.91
R0482:Myo19	UTSW	11	84909419	missense	probably benign	0.00
R1981:Myo19	UTSW	11	84892170	missense	possibly damaging	0.46
R2035:Myo19	UTSW	11	84897608	missense	probably benign
R2185:Myo19	UTSW	11	84892221	missense	probably benign	0.00
R3176:Myo19	UTSW	11	84892175	missense	probably benign	0.01
R3276:Myo19	UTSW	11	84892175	missense	probably benign	0.01
R3824:Myo19	UTSW	11	84885679	missense	probably damaging	0.98
R3914:Myo19	UTSW	11	84894603	missense	probably damaging	1.00
R4333:Myo19	UTSW	11	84908288	missense	probably benign	0.00
R4335:Myo19	UTSW	11	84908288	missense	probably benign	0.00
R4647:Myo19	UTSW	11	84894642	missense	probably damaging	1.00
R4968:Myo19	UTSW	11	84901502	missense	probably damaging	1.00
R4971:Myo19	UTSW	11	84892197	missense	probably damaging	1.00
R5083:Myo19	UTSW	11	84903211	missense	possibly damaging	0.60
R5284:Myo19	UTSW	11	84885272	splice site	probably null
R5558:Myo19	UTSW	11	84910448	missense	probably damaging	1.00
R5739:Myo19	UTSW	11	84897624	missense	probably damaging	1.00
R5982:Myo19	UTSW	11	84899400	missense	probably damaging	0.97
R6093:Myo19	UTSW	11	84885709	missense	probably damaging	1.00
R6444:Myo19	UTSW	11	84895308	missense	probably benign
R6657:Myo19	UTSW	11	84897196	missense	probably benign
R6945:Myo19	UTSW	11	84897560	missense	probably benign	0.06
R7022:Myo19	UTSW	11	84900547	missense	probably damaging	0.99
R7058:Myo19	UTSW	11	84907368	missense	possibly damaging	0.89
R7150:Myo19	UTSW	11	84905613	missense	probably benign
R7155:Myo19	UTSW	11	84900586	missense	probably damaging	1.00
R7478:Myo19	UTSW	11	84885800	missense	probably benign	0.41
R7486:Myo19	UTSW	11	84905637	missense	probably benign
R7833:Myo19	UTSW	11	84909267	missense	probably benign
R7921:Myo19	UTSW	11	84908238	missense	possibly damaging	0.55
R7923:Myo19	UTSW	11	84885710	missense	possibly damaging	0.87
R7927:Myo19	UTSW	11	84900220	missense	probably damaging	1.00
R9105:Myo19	UTSW	11	84903203	missense	probably damaging	0.99
R9714:Myo19	UTSW	11	84882716	start codon destroyed	probably null	0.18
X0053:Myo19	UTSW	11	84897715	nonsense	probably null
Z1176:Myo19	UTSW	11	84885278	missense	probably benign	0.05
Z1176:Myo19	UTSW	11	84909350	frame shift	probably null

Posted On

2015-04-16