Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02342:Wrap73'

289126

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wrap73

Ensembl Gene

ENSMUSG00000029029

Gene Name

WD repeat containing, antisense to Trp73

Synonyms

DD57, 2610044M17Rik, Wdr8, 5330425N03Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.688) question?

Stock #

IGL02342

Quality Score

Status

Chromosome

Chromosomal Location

154226811-154241278 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 154233237 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 137 (Q137L)

Ref Sequence

ENSEMBL: ENSMUSP00000030895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030895]

AlphaFold

Q9JM98

Predicted Effect

probably benign
Transcript: ENSMUST00000030895
AA Change: Q137L

PolyPhen 2 Score 0.357 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000030895
Gene: ENSMUSG00000029029
AA Change: Q137L

Domain	Start	End	E-Value	Type
Blast:WD40	38	77	4e-18	BLAST
Blast:WD40	81	120	6e-16	BLAST
Blast:WD40	125	163	9e-6	BLAST
WD40	167	208	2.28e2	SMART
WD40	215	251	1.58e-2	SMART
WD40	319	360	2.29e1	SMART
WD40	363	401	4.18e-2	SMART
Blast:WD40	402	443	2e-19	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142665

Predicted Effect

probably benign
Transcript: ENSMUST00000146734

SMART Domains

Protein: ENSMUSP00000118548
Gene: ENSMUSG00000029029

Domain	Start	End	E-Value	Type
WD40	28	64	1.58e-2	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	C	A	10: 43,050,997 (GRCm39)	P97Q	probably damaging	Het
Abcb10	A	T	8: 124,688,773 (GRCm39)	V501E	probably damaging	Het
Acsf3	T	C	8: 123,544,237 (GRCm39)	Y572H	probably benign	Het
Adamts3	A	T	5: 89,839,332 (GRCm39)		probably null	Het
Alox8	A	G	11: 69,077,053 (GRCm39)	L480P	probably damaging	Het
Arhgap35	G	A	7: 16,296,305 (GRCm39)	T920I	probably benign	Het
Brca2	C	A	5: 150,466,289 (GRCm39)	L2018M	possibly damaging	Het
Brdt	C	A	5: 107,490,069 (GRCm39)	H45N	probably damaging	Het
C1s2	A	G	6: 124,609,075 (GRCm39)	F155L	probably damaging	Het
Ccser2	A	G	14: 36,640,562 (GRCm39)		probably benign	Het
Cd8a	T	A	6: 71,350,723 (GRCm39)	C63S	probably damaging	Het
Clk2	A	T	3: 89,082,998 (GRCm39)	T424S	probably benign	Het
Cntn1	A	G	15: 92,143,898 (GRCm39)	E287G	probably benign	Het
Cobl	A	C	11: 12,203,672 (GRCm39)	V928G	possibly damaging	Het
Col12a1	A	G	9: 79,557,178 (GRCm39)		probably null	Het
Crnkl1	A	T	2: 145,766,633 (GRCm39)		probably null	Het
Defb26	T	C	2: 152,350,121 (GRCm39)	N53S	possibly damaging	Het
Duox1	A	T	2: 122,177,793 (GRCm39)	T1526S	probably damaging	Het
Dync2h1	A	G	9: 7,142,246 (GRCm39)	L1233P	probably damaging	Het
Eif5a2	A	G	3: 28,847,910 (GRCm39)	E116G	possibly damaging	Het
Garin1b	A	G	6: 29,323,829 (GRCm39)	T185A	possibly damaging	Het
Gdap2	G	A	3: 100,085,632 (GRCm39)	A185T	probably damaging	Het
Grm8	T	C	6: 27,363,803 (GRCm39)	R571G	probably benign	Het
Hjv	G	A	3: 96,435,488 (GRCm39)	D249N	possibly damaging	Het
Hsp90b1	T	C	10: 86,531,603 (GRCm39)		probably null	Het
Ift70a1	G	T	2: 75,810,976 (GRCm39)	T369K	probably benign	Het
Ighv1-75	T	G	12: 115,797,878 (GRCm39)		probably benign	Het
Ikzf1	A	G	11: 11,650,216 (GRCm39)		probably benign	Het
Itprid2	A	G	2: 79,490,629 (GRCm39)	N943S	probably benign	Het
Kdm4d	A	G	9: 14,374,860 (GRCm39)	W333R	probably damaging	Het
Lama3	A	T	18: 12,624,533 (GRCm39)	N1426I	probably damaging	Het
Lmbrd1	A	G	1: 24,743,959 (GRCm39)	Y119C	probably damaging	Het
Mctp1	A	G	13: 77,172,976 (GRCm39)	Y884C	probably damaging	Het
Naip6	G	T	13: 100,439,748 (GRCm39)	P340T	possibly damaging	Het
Nfkbib	G	T	7: 28,461,528 (GRCm39)	H70N	probably damaging	Het
Nol4	A	T	18: 22,903,926 (GRCm39)		probably benign	Het
Obscn	C	T	11: 58,891,914 (GRCm39)	A6873T	probably benign	Het
Or2ag1	A	G	7: 106,313,232 (GRCm39)	S219P	probably benign	Het
Or51b4	T	A	7: 103,530,587 (GRCm39)	I288F	probably benign	Het
Or6x1	T	A	9: 40,098,823 (GRCm39)	N137K	probably benign	Het
Paqr6	A	G	3: 88,273,491 (GRCm39)	Y136C	probably damaging	Het
Pcdh18	T	A	3: 49,710,493 (GRCm39)	D274V	probably damaging	Het
Phip	A	G	9: 82,768,745 (GRCm39)	Y1196H	probably damaging	Het
Prc1	T	C	7: 79,959,190 (GRCm39)	L345S	probably damaging	Het
Smpdl3a	A	G	10: 57,685,276 (GRCm39)		probably benign	Het
Tac1	G	T	6: 7,559,119 (GRCm39)		probably null	Het
Tasor	T	A	14: 27,198,624 (GRCm39)	S1319T	possibly damaging	Het
Tg	A	G	15: 66,636,140 (GRCm39)	T576A	probably benign	Het
Thbs2	A	T	17: 14,896,578 (GRCm39)	D770E	probably damaging	Het
Tmem117	T	C	15: 94,909,331 (GRCm39)	V248A	possibly damaging	Het
Trpm8	T	C	1: 88,255,972 (GRCm39)	I209T	possibly damaging	Het
Wrap53	A	G	11: 69,454,417 (GRCm39)	F244L	probably damaging	Het
Zfhx4	A	T	3: 5,467,434 (GRCm39)	T2531S	probably benign	Het

Other mutations in Wrap73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Wrap73	APN	4	154,237,096 (GRCm39)	missense	probably damaging	0.99
IGL01562:Wrap73	APN	4	154,229,794 (GRCm39)	missense	possibly damaging	0.63
IGL01863:Wrap73	APN	4	154,229,790 (GRCm39)	missense	probably benign	0.02
IGL03012:Wrap73	APN	4	154,229,691 (GRCm39)	splice site	probably benign
IGL03303:Wrap73	APN	4	154,231,000 (GRCm39)	missense	probably damaging	0.98
R0128:Wrap73	UTSW	4	154,226,957 (GRCm39)	missense	possibly damaging	0.81
R0455:Wrap73	UTSW	4	154,233,200 (GRCm39)	missense	possibly damaging	0.63
R0524:Wrap73	UTSW	4	154,229,764 (GRCm39)	missense	probably damaging	1.00
R0528:Wrap73	UTSW	4	154,229,776 (GRCm39)	missense	probably damaging	1.00
R0533:Wrap73	UTSW	4	154,240,611 (GRCm39)	missense	possibly damaging	0.91
R0533:Wrap73	UTSW	4	154,236,106 (GRCm39)	missense	probably damaging	1.00
R0633:Wrap73	UTSW	4	154,226,948 (GRCm39)	missense	probably damaging	0.98
R1118:Wrap73	UTSW	4	154,236,884 (GRCm39)	splice site	probably null
R1669:Wrap73	UTSW	4	154,240,588 (GRCm39)	missense	probably damaging	0.99
R1725:Wrap73	UTSW	4	154,233,209 (GRCm39)	missense	possibly damaging	0.73
R2070:Wrap73	UTSW	4	154,233,200 (GRCm39)	missense	possibly damaging	0.63
R4530:Wrap73	UTSW	4	154,241,164 (GRCm39)	unclassified	probably benign
R4669:Wrap73	UTSW	4	154,236,153 (GRCm39)	missense	probably benign	0.26
R4969:Wrap73	UTSW	4	154,237,138 (GRCm39)	missense	probably damaging	1.00
R5254:Wrap73	UTSW	4	154,239,803 (GRCm39)	missense	probably benign	0.00
R5334:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5428:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5431:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5728:Wrap73	UTSW	4	154,239,099 (GRCm39)	critical splice donor site	probably null
R7338:Wrap73	UTSW	4	154,237,043 (GRCm39)	missense	probably benign	0.26
R7426:Wrap73	UTSW	4	154,240,584 (GRCm39)	missense	probably damaging	1.00
R7480:Wrap73	UTSW	4	154,237,043 (GRCm39)	missense	probably benign	0.26
R7680:Wrap73	UTSW	4	154,241,079 (GRCm39)	missense	probably benign	0.20

Posted On

2015-04-16