Incidental Mutation 'IGL00896:Drgx'
| ID |
28919 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Drgx
|
| Ensembl Gene |
ENSMUSG00000041730 |
| Gene Name |
dorsal root ganglia homeobox |
| Synonyms |
Prrxl1, Drg11 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.601)
|
| Stock # |
IGL00896
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
32321364-32371203 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
C to T
at 32327171 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154801
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068938]
[ENSMUST00000186452]
[ENSMUST00000187377]
[ENSMUST00000189022]
[ENSMUST00000228878]
|
| AlphaFold |
Q8BYH0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000068938
|
| SMART Domains |
Protein: ENSMUSP00000064107
Gene: ENSMUSG00000041730
| Domain | Start | End | E-Value | Type |
|---|
|
HOX
|
33 |
95 |
9.62e-29 |
SMART |
|
low complexity region
|
111 |
122 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186452
|
| SMART Domains |
Protein: ENSMUSP00000139756
Gene: ENSMUSG00000041730
| Domain | Start | End | E-Value | Type |
|---|
|
HOX
|
33 |
95 |
9.62e-29 |
SMART |
|
low complexity region
|
111 |
122 |
N/A |
INTRINSIC |
|
Pfam:OAR
|
199 |
219 |
4.4e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187377
|
| SMART Domains |
Protein: ENSMUSP00000140687
Gene: ENSMUSG00000041730
| Domain | Start | End | E-Value | Type |
|---|
|
HOX
|
33 |
95 |
9.62e-29 |
SMART |
|
low complexity region
|
111 |
122 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189022
|
| SMART Domains |
Protein: ENSMUSP00000140337
Gene: ENSMUSG00000041730
| Domain | Start | End | E-Value | Type |
|---|
|
HOX
|
33 |
95 |
9.62e-29 |
SMART |
|
low complexity region
|
111 |
122 |
N/A |
INTRINSIC |
|
Pfam:OAR
|
199 |
219 |
4.4e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228878
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice had delayed projection of sensory afferent neurons in the dorsal, but not the ventral, spinal cord during embryonic development. This delayed development resulted in abnormal responses to noxious stimuli in adults, but normal locomotion and sensory motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam6a |
A |
G |
12: 113,509,030 (GRCm39) |
T468A |
possibly damaging |
Het |
| Ankrd35 |
A |
G |
3: 96,591,592 (GRCm39) |
E626G |
probably damaging |
Het |
| Arhgef4 |
A |
G |
1: 34,850,777 (GRCm39) |
Y1812C |
possibly damaging |
Het |
| Aurkc |
T |
C |
7: 7,005,513 (GRCm39) |
Y260H |
possibly damaging |
Het |
| Bltp1 |
A |
G |
3: 37,093,611 (GRCm39) |
T4352A |
probably benign |
Het |
| Cpb1 |
A |
G |
3: 20,306,193 (GRCm39) |
V329A |
probably benign |
Het |
| Cyp2d11 |
G |
T |
15: 82,275,275 (GRCm39) |
|
probably benign |
Het |
| Dnase1 |
G |
A |
16: 3,857,076 (GRCm39) |
S28N |
probably benign |
Het |
| Evpl |
C |
A |
11: 116,113,410 (GRCm39) |
E1427* |
probably null |
Het |
| Gimap6 |
T |
C |
6: 48,679,394 (GRCm39) |
N214S |
probably benign |
Het |
| Htr1f |
A |
T |
16: 64,746,469 (GRCm39) |
H274Q |
probably benign |
Het |
| Ipo9 |
A |
T |
1: 135,327,797 (GRCm39) |
V538E |
probably damaging |
Het |
| Lmf2 |
T |
C |
15: 89,237,539 (GRCm39) |
K308E |
probably benign |
Het |
| Mog |
T |
A |
17: 37,328,377 (GRCm39) |
|
probably null |
Het |
| Myo19 |
T |
C |
11: 84,800,324 (GRCm39) |
V903A |
probably benign |
Het |
| Myt1l |
A |
G |
12: 29,876,885 (GRCm39) |
T179A |
unknown |
Het |
| Nckap1 |
C |
T |
2: 80,411,297 (GRCm39) |
V5M |
possibly damaging |
Het |
| Or1e23 |
T |
C |
11: 73,407,167 (GRCm39) |
N286S |
probably damaging |
Het |
| Or51l4 |
T |
C |
7: 103,404,213 (GRCm39) |
D193G |
probably damaging |
Het |
| Or9a2 |
A |
T |
6: 41,749,047 (GRCm39) |
L62Q |
probably damaging |
Het |
| Pcdhb5 |
T |
G |
18: 37,455,838 (GRCm39) |
|
probably null |
Het |
| Pcm1 |
C |
A |
8: 41,729,160 (GRCm39) |
Q711K |
possibly damaging |
Het |
| Pde6a |
A |
G |
18: 61,353,864 (GRCm39) |
D63G |
possibly damaging |
Het |
| Piezo1 |
T |
C |
8: 123,224,609 (GRCm39) |
M711V |
possibly damaging |
Het |
| Rev1 |
G |
A |
1: 38,138,021 (GRCm39) |
T88I |
probably damaging |
Het |
| Sntg1 |
A |
T |
1: 8,665,634 (GRCm39) |
|
probably null |
Het |
| Sult2a1 |
T |
A |
7: 13,566,565 (GRCm39) |
T137S |
probably benign |
Het |
| Txndc15 |
G |
A |
13: 55,873,488 (GRCm39) |
A283T |
probably damaging |
Het |
| Zswim8 |
A |
G |
14: 20,766,069 (GRCm39) |
E785G |
probably damaging |
Het |
|
| Other mutations in Drgx |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01868:Drgx
|
APN |
14 |
32,330,334 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0436:Drgx
|
UTSW |
14 |
32,330,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1395:Drgx
|
UTSW |
14 |
32,330,326 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1574:Drgx
|
UTSW |
14 |
32,327,281 (GRCm39) |
splice site |
probably benign |
|
|
R2093:Drgx
|
UTSW |
14 |
32,369,112 (GRCm39) |
intron |
probably benign |
|
|
R3700:Drgx
|
UTSW |
14 |
32,350,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4922:Drgx
|
UTSW |
14 |
32,330,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4944:Drgx
|
UTSW |
14 |
32,330,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4962:Drgx
|
UTSW |
14 |
32,369,101 (GRCm39) |
intron |
probably benign |
|
|
R5512:Drgx
|
UTSW |
14 |
32,322,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5989:Drgx
|
UTSW |
14 |
32,330,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7423:Drgx
|
UTSW |
14 |
32,350,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7790:Drgx
|
UTSW |
14 |
32,350,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9171:Drgx
|
UTSW |
14 |
32,330,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-04-17 |
Incidental Mutation