Incidental Mutation 'IGL02345:Prr16'
ID289233
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prr16
Ensembl Gene ENSMUSG00000073565
Gene Nameproline rich 16
Synonyms5430406M13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL02345
Quality Score
Status
Chromosome18
Chromosomal Location51117898-51304641 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 51303229 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 260 (F260S)
Ref Sequence ENSEMBL: ENSMUSP00000112338 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000116639]
Predicted Effect probably damaging
Transcript: ENSMUST00000116639
AA Change: F260S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000112338
Gene: ENSMUSG00000073565
AA Change: F260S

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
Pfam:DUF4589 53 304 4.4e-80 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 G T 16: 14,396,351 D177Y possibly damaging Het
Casc3 T C 11: 98,827,564 probably benign Het
Cnga1 C T 5: 72,605,272 V300I probably benign Het
Dcun1d4 A G 5: 73,511,152 D41G probably damaging Het
Dnm1l T C 16: 16,329,894 S181G possibly damaging Het
Dyrk1a T G 16: 94,671,362 S242A possibly damaging Het
Fcgbp T A 7: 28,071,643 probably benign Het
Fibcd1 T C 2: 31,816,592 Y409C probably damaging Het
Fig4 A T 10: 41,267,774 W230R probably null Het
Flt1 T C 5: 147,582,626 S960G probably benign Het
Fyb A G 15: 6,619,662 S390G possibly damaging Het
Gbx2 T C 1: 89,928,976 T231A probably benign Het
Gm16432 G A 1: 178,015,188 V60I possibly damaging Het
Gm5852 T A 3: 93,727,748 noncoding transcript Het
Lmo7 T C 14: 101,887,473 V456A probably damaging Het
Mark3 A G 12: 111,627,107 N191S probably damaging Het
Olfr871 C A 9: 20,213,018 S223Y possibly damaging Het
Pik3c2a C T 7: 116,405,891 E381K probably damaging Het
Pik3r5 A G 11: 68,492,726 D457G probably benign Het
Plcg2 T C 8: 117,585,180 S404P probably damaging Het
Psd4 T C 2: 24,401,823 probably null Het
Ptgs1 A G 2: 36,242,971 D327G probably null Het
Rgsl1 C T 1: 153,804,009 probably null Het
Spg20 T A 3: 55,117,726 probably null Het
Sugp1 A G 8: 70,043,084 probably benign Het
Tubgcp3 A T 8: 12,625,056 I713N probably damaging Het
Usp19 A G 9: 108,493,858 T240A probably benign Het
Vash2 A G 1: 190,978,215 V81A probably benign Het
Vmn2r41 T G 7: 8,138,768 N566H probably damaging Het
Wdr31 A G 4: 62,458,846 I42T possibly damaging Het
Zfp292 C T 4: 34,809,244 V1272I possibly damaging Het
Zfp638 C T 6: 83,984,875 R1899C probably damaging Het
Other mutations in Prr16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Prr16 APN 18 51303120 missense possibly damaging 0.82
IGL00951:Prr16 APN 18 51303339 missense probably damaging 1.00
IGL01744:Prr16 APN 18 51302989 missense possibly damaging 0.73
IGL02833:Prr16 APN 18 51303092 missense probably damaging 1.00
LCD18:Prr16 UTSW 18 51200324 intron probably benign
R1195:Prr16 UTSW 18 51302683 missense probably damaging 1.00
R1195:Prr16 UTSW 18 51302683 missense probably damaging 1.00
R1195:Prr16 UTSW 18 51302683 missense probably damaging 1.00
R1572:Prr16 UTSW 18 51302970 missense probably benign 0.01
R1988:Prr16 UTSW 18 51303277 missense probably damaging 1.00
R3436:Prr16 UTSW 18 51303123 missense probably benign 0.00
R3685:Prr16 UTSW 18 51302820 missense probably damaging 0.99
R4609:Prr16 UTSW 18 51118067 missense possibly damaging 0.79
R4626:Prr16 UTSW 18 51302839 missense probably damaging 1.00
R5443:Prr16 UTSW 18 51303153 missense probably damaging 1.00
R5713:Prr16 UTSW 18 51302838 missense probably damaging 1.00
R6525:Prr16 UTSW 18 51303155 missense probably benign 0.01
Z1176:Prr16 UTSW 18 51303150 missense probably damaging 1.00
Posted On2015-04-16