Incidental Mutation 'IGL02345:Olfr871'
ID289234
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr871
Ensembl Gene ENSMUSG00000061457
Gene Nameolfactory receptor 871
SynonymsGA_x6K02T2PVTD-13952555-13953490, MOR141-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02345
Quality Score
Status
Chromosome9
Chromosomal Location20212207-20213353 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 20213018 bp
ZygosityHeterozygous
Amino Acid Change Serine to Tyrosine at position 223 (S223Y)
Ref Sequence ENSEMBL: ENSMUSP00000072865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073122]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073122
AA Change: S223Y

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072865
Gene: ENSMUSG00000061457
AA Change: S223Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 8.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.1e-7 PFAM
Pfam:7tm_1 41 290 9.1e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158891
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 G T 16: 14,396,351 D177Y possibly damaging Het
Casc3 T C 11: 98,827,564 probably benign Het
Cnga1 C T 5: 72,605,272 V300I probably benign Het
Dcun1d4 A G 5: 73,511,152 D41G probably damaging Het
Dnm1l T C 16: 16,329,894 S181G possibly damaging Het
Dyrk1a T G 16: 94,671,362 S242A possibly damaging Het
Fcgbp T A 7: 28,071,643 probably benign Het
Fibcd1 T C 2: 31,816,592 Y409C probably damaging Het
Fig4 A T 10: 41,267,774 W230R probably null Het
Flt1 T C 5: 147,582,626 S960G probably benign Het
Fyb A G 15: 6,619,662 S390G possibly damaging Het
Gbx2 T C 1: 89,928,976 T231A probably benign Het
Gm16432 G A 1: 178,015,188 V60I possibly damaging Het
Gm5852 T A 3: 93,727,748 noncoding transcript Het
Lmo7 T C 14: 101,887,473 V456A probably damaging Het
Mark3 A G 12: 111,627,107 N191S probably damaging Het
Pik3c2a C T 7: 116,405,891 E381K probably damaging Het
Pik3r5 A G 11: 68,492,726 D457G probably benign Het
Plcg2 T C 8: 117,585,180 S404P probably damaging Het
Prr16 T C 18: 51,303,229 F260S probably damaging Het
Psd4 T C 2: 24,401,823 probably null Het
Ptgs1 A G 2: 36,242,971 D327G probably null Het
Rgsl1 C T 1: 153,804,009 probably null Het
Spg20 T A 3: 55,117,726 probably null Het
Sugp1 A G 8: 70,043,084 probably benign Het
Tubgcp3 A T 8: 12,625,056 I713N probably damaging Het
Usp19 A G 9: 108,493,858 T240A probably benign Het
Vash2 A G 1: 190,978,215 V81A probably benign Het
Vmn2r41 T G 7: 8,138,768 N566H probably damaging Het
Wdr31 A G 4: 62,458,846 I42T possibly damaging Het
Zfp292 C T 4: 34,809,244 V1272I possibly damaging Het
Zfp638 C T 6: 83,984,875 R1899C probably damaging Het
Other mutations in Olfr871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Olfr871 APN 9 20212459 missense possibly damaging 0.89
IGL02291:Olfr871 APN 9 20212802 missense probably benign 0.00
IGL02312:Olfr871 APN 9 20213081 missense probably damaging 1.00
R0278:Olfr871 UTSW 9 20212886 missense probably damaging 1.00
R0520:Olfr871 UTSW 9 20212495 missense probably benign 0.01
R1606:Olfr871 UTSW 9 20212946 missense probably benign 0.05
R3751:Olfr871 UTSW 9 20213260 missense probably damaging 0.98
R4701:Olfr871 UTSW 9 20212625 missense probably damaging 1.00
R4811:Olfr871 UTSW 9 20212753 missense probably damaging 1.00
R5074:Olfr871 UTSW 9 20212582 missense possibly damaging 0.63
R5406:Olfr871 UTSW 9 20213158 missense probably benign 0.08
R6541:Olfr871 UTSW 9 20212399 missense probably benign 0.01
R6730:Olfr871 UTSW 9 20212502 missense probably benign 0.04
R7195:Olfr871 UTSW 9 20212544 missense probably damaging 0.99
R7197:Olfr871 UTSW 9 20212555 missense probably benign 0.00
R7384:Olfr871 UTSW 9 20212745 missense probably damaging 1.00
R7715:Olfr871 UTSW 9 20212435 missense probably damaging 0.97
R7715:Olfr871 UTSW 9 20212436 missense probably benign 0.06
R8108:Olfr871 UTSW 9 20212451 missense possibly damaging 0.62
RF013:Olfr871 UTSW 9 20212894 missense probably benign 0.00
Z1176:Olfr871 UTSW 9 20212844 missense possibly damaging 0.94
Z1177:Olfr871 UTSW 9 20213186 missense probably damaging 1.00
Posted On2015-04-16