Incidental Mutation 'IGL02345:Gm16432'
ID289238
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm16432
Ensembl Gene ENSMUSG00000091476
Gene Namepredicted gene 16432
SynonymsEG545391
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL02345
Quality Score
Status
Chromosome1
Chromosomal Location177983423-178172704 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 178015188 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 60 (V60I)
Ref Sequence ENSEMBL: ENSMUSP00000142187 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094273] [ENSMUST00000192146]
Predicted Effect possibly damaging
Transcript: ENSMUST00000094273
AA Change: V60I

PolyPhen 2 Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000091828
Gene: ENSMUSG00000091476
AA Change: V60I

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191719
Predicted Effect possibly damaging
Transcript: ENSMUST00000192146
AA Change: V60I

PolyPhen 2 Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000142187
Gene: ENSMUSG00000091476
AA Change: V60I

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:CATSPERD 207 774 1.7e-200 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 G T 16: 14,396,351 D177Y possibly damaging Het
Casc3 T C 11: 98,827,564 probably benign Het
Cnga1 C T 5: 72,605,272 V300I probably benign Het
Dcun1d4 A G 5: 73,511,152 D41G probably damaging Het
Dnm1l T C 16: 16,329,894 S181G possibly damaging Het
Dyrk1a T G 16: 94,671,362 S242A possibly damaging Het
Fcgbp T A 7: 28,071,643 probably benign Het
Fibcd1 T C 2: 31,816,592 Y409C probably damaging Het
Fig4 A T 10: 41,267,774 W230R probably null Het
Flt1 T C 5: 147,582,626 S960G probably benign Het
Fyb A G 15: 6,619,662 S390G possibly damaging Het
Gbx2 T C 1: 89,928,976 T231A probably benign Het
Gm5852 T A 3: 93,727,748 noncoding transcript Het
Lmo7 T C 14: 101,887,473 V456A probably damaging Het
Mark3 A G 12: 111,627,107 N191S probably damaging Het
Olfr871 C A 9: 20,213,018 S223Y possibly damaging Het
Pik3c2a C T 7: 116,405,891 E381K probably damaging Het
Pik3r5 A G 11: 68,492,726 D457G probably benign Het
Plcg2 T C 8: 117,585,180 S404P probably damaging Het
Prr16 T C 18: 51,303,229 F260S probably damaging Het
Psd4 T C 2: 24,401,823 probably null Het
Ptgs1 A G 2: 36,242,971 D327G probably null Het
Rgsl1 C T 1: 153,804,009 probably null Het
Spg20 T A 3: 55,117,726 probably null Het
Sugp1 A G 8: 70,043,084 probably benign Het
Tubgcp3 A T 8: 12,625,056 I713N probably damaging Het
Usp19 A G 9: 108,493,858 T240A probably benign Het
Vash2 A G 1: 190,978,215 V81A probably benign Het
Vmn2r41 T G 7: 8,138,768 N566H probably damaging Het
Wdr31 A G 4: 62,458,846 I42T possibly damaging Het
Zfp292 C T 4: 34,809,244 V1272I possibly damaging Het
Zfp638 C T 6: 83,984,875 R1899C probably damaging Het
Other mutations in Gm16432
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Gm16432 APN 1 178015121 splice site probably benign
R0089:Gm16432 UTSW 1 178046989 missense unknown
R0103:Gm16432 UTSW 1 178116205 missense unknown
R1491:Gm16432 UTSW 1 178015929 missense possibly damaging 0.92
R1662:Gm16432 UTSW 1 178046986 missense unknown
R1840:Gm16432 UTSW 1 178003015 missense possibly damaging 0.90
R2168:Gm16432 UTSW 1 178015911 splice site probably benign
R3764:Gm16432 UTSW 1 178113132 missense unknown
R4586:Gm16432 UTSW 1 178122785 missense possibly damaging 0.90
R4887:Gm16432 UTSW 1 178103949 missense unknown
R4990:Gm16432 UTSW 1 178098421 missense probably benign 0.14
R4991:Gm16432 UTSW 1 178098421 missense probably benign 0.14
R5225:Gm16432 UTSW 1 178148908 utr 3 prime probably benign
R5285:Gm16432 UTSW 1 178103888 missense unknown
R5569:Gm16432 UTSW 1 178111596 missense possibly damaging 0.82
R5743:Gm16432 UTSW 1 178122762 splice site silent
R5756:Gm16432 UTSW 1 178116227 missense unknown
R6050:Gm16432 UTSW 1 178103924 missense unknown
R6166:Gm16432 UTSW 1 178103837 missense unknown
R6200:Gm16432 UTSW 1 178111558 missense possibly damaging 0.66
R6322:Gm16432 UTSW 1 178017730 nonsense probably null
R6438:Gm16432 UTSW 1 178111303 missense possibly damaging 0.92
R6736:Gm16432 UTSW 1 178017712 nonsense probably null
Posted On2015-04-16