Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02346:Serpinb9g'

289265

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Serpinb9g

Ensembl Gene

ENSMUSG00000057726

Gene Name

serine (or cysteine) peptidase inhibitor, clade B, member 9g

Synonyms

ovalbumin, NK21B, 1600002F03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.221) question?

Stock #

IGL02346

Quality Score

Status

Chromosome

Chromosomal Location

33668773-33679985 bp(+) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 33670514 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 1 (M1L)

Ref Sequence

ENSEMBL: ENSMUSP00000080597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081927]

AlphaFold

Q8VHQ1

Predicted Effect

probably benign
Transcript: ENSMUST00000081927
AA Change: M1L

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000080597
Gene: ENSMUSG00000057726
AA Change: M1L

Domain	Start	End	E-Value	Type
SERPIN	13	377	2.87e-166	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	A	T	5: 114,376,760 (GRCm39)	I1948F	probably damaging	Het
Adgre1	T	C	17: 57,750,919 (GRCm39)	V531A	probably benign	Het
Ano3	A	T	2: 110,601,271 (GRCm39)		probably benign	Het
Api5	A	T	2: 94,257,875 (GRCm39)	F125I	possibly damaging	Het
Arhgap21	A	G	2: 20,884,762 (GRCm39)		probably benign	Het
Atp13a5	T	A	16: 29,146,554 (GRCm39)	K247*	probably null	Het
Col9a1	C	T	1: 24,262,690 (GRCm39)	A585V	probably damaging	Het
Eef1akmt3	A	G	10: 126,868,805 (GRCm39)	V223A	probably benign	Het
Eml1	T	C	12: 108,503,700 (GRCm39)	S766P	possibly damaging	Het
Fam13b	G	T	18: 34,595,158 (GRCm39)	A402E	probably benign	Het
Gad2	A	G	2: 22,519,951 (GRCm39)		probably benign	Het
Gbf1	A	G	19: 46,274,369 (GRCm39)	E1859G	probably damaging	Het
Gli3	T	G	13: 15,898,278 (GRCm39)	V786G	probably damaging	Het
Gm5592	A	G	7: 40,938,889 (GRCm39)	S724G	probably damaging	Het
Hgs	A	G	11: 120,373,377 (GRCm39)	Y634C	probably damaging	Het
Hoxa3	T	A	6: 52,147,579 (GRCm39)		probably benign	Het
Id4	C	A	13: 48,415,189 (GRCm39)	Y72*	probably null	Het
Il5ra	T	A	6: 106,719,619 (GRCm39)	E71D	probably benign	Het
Kcnh4	G	A	11: 100,647,768 (GRCm39)	T168M	possibly damaging	Het
Kdm3b	A	T	18: 34,967,291 (GRCm39)	I1699L	probably damaging	Het
Madd	A	G	2: 90,992,836 (GRCm39)	Y1048H	probably damaging	Het
Mix23	T	C	16: 35,912,205 (GRCm39)	V87A	probably damaging	Het
Nr2f1	C	A	13: 78,343,527 (GRCm39)	V246L	probably damaging	Het
Oas2	A	T	5: 120,874,153 (GRCm39)	I560N	probably benign	Het
Or1j17	A	T	2: 36,578,016 (GRCm39)	M1L	probably benign	Het
Or1m1	T	C	9: 18,666,065 (GRCm39)	I289V	probably damaging	Het
Or8g19	T	C	9: 39,055,939 (GRCm39)	L181P	probably damaging	Het
Pclo	A	G	5: 14,727,552 (GRCm39)		probably benign	Het
Pdss2	T	C	10: 43,221,639 (GRCm39)	F184L	possibly damaging	Het
Prpf39	C	T	12: 65,104,510 (GRCm39)	T525I	probably benign	Het
Ralgps1	A	T	2: 33,047,782 (GRCm39)		probably null	Het
Rasal3	A	G	17: 32,618,323 (GRCm39)	W161R	probably damaging	Het
Sema5b	T	A	16: 35,470,125 (GRCm39)	V329D	probably damaging	Het
Sptb	C	T	12: 76,667,788 (GRCm39)	D770N	probably damaging	Het
Tdp2	T	C	13: 25,025,335 (GRCm39)	V368A	possibly damaging	Het
Uggt1	A	G	1: 36,218,751 (GRCm39)	S59P	probably benign	Het
Vmn2r130	T	C	17: 23,280,501 (GRCm39)	V54A	possibly damaging	Het
Vmn2r9	T	A	5: 108,990,850 (GRCm39)	N837I	probably benign	Het
Wdr7	A	T	18: 63,998,407 (GRCm39)	E1118V	probably benign	Het
Wwox	A	G	8: 115,438,858 (GRCm39)	H308R	probably benign	Het
Zbtb41	C	A	1: 139,374,838 (GRCm39)	P766Q	probably damaging	Het

Other mutations in Serpinb9g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01655:Serpinb9g	APN	13	33,679,088 (GRCm39)	nonsense	probably null
IGL02665:Serpinb9g	APN	13	33,679,086 (GRCm39)	missense	possibly damaging	0.54
IGL02936:Serpinb9g	APN	13	33,678,865 (GRCm39)	missense	possibly damaging	0.94
R1611:Serpinb9g	UTSW	13	33,676,857 (GRCm39)	missense	possibly damaging	0.46
R3873:Serpinb9g	UTSW	13	33,670,518 (GRCm39)	missense	probably benign	0.45
R4060:Serpinb9g	UTSW	13	33,679,089 (GRCm39)	missense	probably benign	0.19
R4505:Serpinb9g	UTSW	13	33,670,546 (GRCm39)	missense	probably damaging	1.00
R6399:Serpinb9g	UTSW	13	33,676,834 (GRCm39)	missense	probably benign
R6843:Serpinb9g	UTSW	13	33,676,900 (GRCm39)	missense	probably damaging	1.00
R6844:Serpinb9g	UTSW	13	33,670,616 (GRCm39)	missense	probably damaging	0.99
R6942:Serpinb9g	UTSW	13	33,678,888 (GRCm39)	missense	probably benign	0.03
R7319:Serpinb9g	UTSW	13	33,672,543 (GRCm39)	nonsense	probably null
R7466:Serpinb9g	UTSW	13	33,679,150 (GRCm39)	missense	probably benign
R7470:Serpinb9g	UTSW	13	33,670,617 (GRCm39)	missense	probably damaging	1.00
R8350:Serpinb9g	UTSW	13	33,676,854 (GRCm39)	missense	probably damaging	1.00
R8531:Serpinb9g	UTSW	13	33,676,896 (GRCm39)	missense	possibly damaging	0.46
R8555:Serpinb9g	UTSW	13	33,676,796 (GRCm39)	missense	probably benign	0.02
R8743:Serpinb9g	UTSW	13	33,678,931 (GRCm39)	missense	probably benign
R8918:Serpinb9g	UTSW	13	33,679,131 (GRCm39)	missense	probably benign	0.00
R9542:Serpinb9g	UTSW	13	33,679,141 (GRCm39)	missense	probably benign	0.12

Posted On

2015-04-16