Incidental Mutation 'IGL02349:Olfr61'
ID289398
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr61
Ensembl Gene ENSMUSG00000096069
Gene Nameolfactory receptor 61
SynonymsMOR253-1, IH7, GA_x6K02T2PBJ9-42783826-42784758
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.118) question?
Stock #IGL02349
Quality Score
Status
Chromosome7
Chromosomal Location140628970-140638798 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 140638471 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 257 (F257L)
Ref Sequence ENSEMBL: ENSMUSP00000147924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084455] [ENSMUST00000210241] [ENSMUST00000210373] [ENSMUST00000211685]
Predicted Effect probably benign
Transcript: ENSMUST00000084455
AA Change: F257L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000081493
Gene: ENSMUSG00000096069
AA Change: F257L

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 175 1.3e-8 PFAM
Pfam:7tm_1 42 291 3.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210241
AA Change: F257L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000210373
Predicted Effect probably benign
Transcript: ENSMUST00000211685
AA Change: F257L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 A G 5: 24,406,464 I484V probably benign Het
Acly C T 11: 100,519,679 E158K probably benign Het
Akap3 T A 6: 126,860,263 D3E probably benign Het
Alg8 A G 7: 97,379,894 N152S possibly damaging Het
Ano7 A G 1: 93,391,490 T323A probably benign Het
Bmp1 T C 14: 70,507,549 Y252C possibly damaging Het
Cacnb3 A T 15: 98,640,961 K159* probably null Het
Capns2 T A 8: 92,902,062 V193D probably benign Het
Cct2 A G 10: 117,053,139 I48T probably benign Het
Cep152 A G 2: 125,594,956 S555P probably damaging Het
Col5a3 T C 9: 20,772,361 E1533G unknown Het
Cyp17a1 A G 19: 46,667,497 L451P probably damaging Het
D1Ertd622e A G 1: 97,646,052 L96P probably damaging Het
Dgcr8 T C 16: 18,280,306 E407G possibly damaging Het
Dhx57 T A 17: 80,255,571 N876Y probably damaging Het
Dnah7b T A 1: 46,099,503 L235* probably null Het
Fgfr2 A G 7: 130,242,606 Y50H probably damaging Het
Gars T A 6: 55,048,064 probably benign Het
Gfpt2 A T 11: 49,807,703 I42F probably benign Het
Glcci1 A G 6: 8,558,581 K35E probably damaging Het
Gpatch1 T A 7: 35,307,255 M163L probably damaging Het
Gpr132 T C 12: 112,852,855 Y117C probably damaging Het
Ints1 G A 5: 139,768,468 P650S probably damaging Het
Itga2b T C 11: 102,461,363 D464G probably damaging Het
Kansl2 C A 15: 98,529,446 G185C probably damaging Het
Kat6b T A 14: 21,637,593 M570K probably damaging Het
Map3k19 T A 1: 127,823,769 D615V possibly damaging Het
Map3k7cl A G 16: 87,556,013 probably benign Het
Msto1 A C 3: 88,910,898 S360R possibly damaging Het
Myo15b C A 11: 115,863,105 probably benign Het
Nhlrc2 T C 19: 56,591,719 V428A possibly damaging Het
Olfr33 G A 7: 102,714,126 R96C probably damaging Het
Olfr348 A C 2: 36,787,046 T174P possibly damaging Het
Olfr470 A G 7: 107,845,605 S43P probably benign Het
Olfr568 A T 7: 102,877,909 Y263F probably benign Het
Olfr874 T A 9: 37,746,206 M24K probably benign Het
Pcm1 G T 8: 41,288,155 probably null Het
Plekhg3 A T 12: 76,562,300 N149I probably damaging Het
Rbp3 C A 14: 33,955,719 H541Q probably damaging Het
Rgp1 T C 4: 43,581,236 probably null Het
Scyl2 A T 10: 89,657,938 probably benign Het
Tas2r144 A C 6: 42,216,076 H250P probably benign Het
Tmppe T C 9: 114,405,200 V189A probably benign Het
Trp53bp1 G A 2: 121,199,074 S1875L probably damaging Het
Txnl4a T A 18: 80,218,729 L60H probably damaging Het
Upp2 A G 2: 58,777,886 D217G probably benign Het
Vmn2r74 A G 7: 85,952,516 L638P probably damaging Het
Vnn1 A G 10: 23,898,503 N148S possibly damaging Het
Xrcc1 C T 7: 24,567,042 Q241* probably null Het
Zfp990 A G 4: 145,530,877 probably benign Het
Other mutations in Olfr61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr61 APN 7 140638256 missense probably damaging 1.00
IGL01837:Olfr61 APN 7 140638211 missense probably damaging 1.00
IGL02713:Olfr61 APN 7 140637916 missense probably damaging 0.98
IGL02982:Olfr61 APN 7 140637952 missense probably benign 0.06
IGL03205:Olfr61 APN 7 140638160 missense possibly damaging 0.90
R1477:Olfr61 UTSW 7 140638442 missense possibly damaging 0.94
R1564:Olfr61 UTSW 7 140638054 missense probably benign 0.21
R1900:Olfr61 UTSW 7 140638592 missense probably damaging 0.99
R2149:Olfr61 UTSW 7 140638052 missense probably damaging 0.99
R2504:Olfr61 UTSW 7 140638484 missense probably benign 0.01
R2887:Olfr61 UTSW 7 140638225 missense probably damaging 1.00
R3787:Olfr61 UTSW 7 140637835 missense probably benign 0.01
R4628:Olfr61 UTSW 7 140638384 missense probably benign 0.04
R4775:Olfr61 UTSW 7 140637916 missense probably damaging 0.98
R5805:Olfr61 UTSW 7 140638471 missense probably benign 0.00
R6019:Olfr61 UTSW 7 140638012 missense probably benign 0.03
R6244:Olfr61 UTSW 7 140638433 missense probably damaging 1.00
R7303:Olfr61 UTSW 7 140638354 missense probably damaging 1.00
R7505:Olfr61 UTSW 7 140638052 missense probably damaging 1.00
R7783:Olfr61 UTSW 7 140637724 missense possibly damaging 0.86
Z1088:Olfr61 UTSW 7 140638220 missense probably benign
Posted On2015-04-16