Incidental Mutation 'IGL02349:Vmn2r74'
ID 289402
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r74
Ensembl Gene ENSMUSG00000090774
Gene Name vomeronasal 2, receptor 74
Synonyms EG546980
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # IGL02349
Quality Score
Status
Chromosome 7
Chromosomal Location 85601075-85610690 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85601724 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 638 (L638P)
Ref Sequence ENSEMBL: ENSMUSP00000126917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166355]
AlphaFold E9PW21
Predicted Effect probably damaging
Transcript: ENSMUST00000166355
AA Change: L638P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: L638P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 467 7.3e-28 PFAM
Pfam:NCD3G 510 562 4.7e-20 PFAM
Pfam:7tm_3 592 830 1.3e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 A G 5: 24,611,462 (GRCm39) I484V probably benign Het
Acly C T 11: 100,410,505 (GRCm39) E158K probably benign Het
Akap3 T A 6: 126,837,226 (GRCm39) D3E probably benign Het
Alg8 A G 7: 97,029,101 (GRCm39) N152S possibly damaging Het
Ano7 A G 1: 93,319,212 (GRCm39) T323A probably benign Het
Bmp1 T C 14: 70,744,989 (GRCm39) Y252C possibly damaging Het
Cacnb3 A T 15: 98,538,842 (GRCm39) K159* probably null Het
Capns2 T A 8: 93,628,690 (GRCm39) V193D probably benign Het
Cct2 A G 10: 116,889,044 (GRCm39) I48T probably benign Het
Cep152 A G 2: 125,436,876 (GRCm39) S555P probably damaging Het
Col5a3 T C 9: 20,683,657 (GRCm39) E1533G unknown Het
Cyp17a1 A G 19: 46,655,936 (GRCm39) L451P probably damaging Het
Dgcr8 T C 16: 18,098,170 (GRCm39) E407G possibly damaging Het
Dhx57 T A 17: 80,563,000 (GRCm39) N876Y probably damaging Het
Dnah7b T A 1: 46,138,663 (GRCm39) L235* probably null Het
Fgfr2 A G 7: 129,844,336 (GRCm39) Y50H probably damaging Het
Gars1 T A 6: 55,025,049 (GRCm39) probably benign Het
Gfpt2 A T 11: 49,698,530 (GRCm39) I42F probably benign Het
Glcci1 A G 6: 8,558,581 (GRCm39) K35E probably damaging Het
Gpatch1 T A 7: 35,006,680 (GRCm39) M163L probably damaging Het
Gpr132 T C 12: 112,816,475 (GRCm39) Y117C probably damaging Het
Ints1 G A 5: 139,754,223 (GRCm39) P650S probably damaging Het
Itga2b T C 11: 102,352,189 (GRCm39) D464G probably damaging Het
Kansl2 C A 15: 98,427,327 (GRCm39) G185C probably damaging Het
Kat6b T A 14: 21,687,661 (GRCm39) M570K probably damaging Het
Macir A G 1: 97,573,777 (GRCm39) L96P probably damaging Het
Map3k19 T A 1: 127,751,506 (GRCm39) D615V possibly damaging Het
Map3k7cl A G 16: 87,352,901 (GRCm39) probably benign Het
Msto1 A C 3: 88,818,205 (GRCm39) S360R possibly damaging Het
Myo15b C A 11: 115,753,931 (GRCm39) probably benign Het
Nhlrc2 T C 19: 56,580,151 (GRCm39) V428A possibly damaging Het
Or13a28 T C 7: 140,218,384 (GRCm39) F257L probably benign Het
Or1j19 A C 2: 36,677,058 (GRCm39) T174P possibly damaging Het
Or51a39 G A 7: 102,363,333 (GRCm39) R96C probably damaging Het
Or51f2 A T 7: 102,527,116 (GRCm39) Y263F probably benign Het
Or5p51 A G 7: 107,444,812 (GRCm39) S43P probably benign Het
Or8b12 T A 9: 37,657,502 (GRCm39) M24K probably benign Het
Pcm1 G T 8: 41,741,192 (GRCm39) probably null Het
Plekhg3 A T 12: 76,609,074 (GRCm39) N149I probably damaging Het
Rbp3 C A 14: 33,677,676 (GRCm39) H541Q probably damaging Het
Rgp1 T C 4: 43,581,236 (GRCm39) probably null Het
Scyl2 A T 10: 89,493,800 (GRCm39) probably benign Het
Tas2r144 A C 6: 42,193,010 (GRCm39) H250P probably benign Het
Tmppe T C 9: 114,234,268 (GRCm39) V189A probably benign Het
Trp53bp1 G A 2: 121,029,555 (GRCm39) S1875L probably damaging Het
Txnl4a T A 18: 80,261,944 (GRCm39) L60H probably damaging Het
Upp2 A G 2: 58,667,898 (GRCm39) D217G probably benign Het
Vnn1 A G 10: 23,774,401 (GRCm39) N148S possibly damaging Het
Xrcc1 C T 7: 24,266,467 (GRCm39) Q241* probably null Het
Zfp990 A G 4: 145,257,447 (GRCm39) probably benign Het
Other mutations in Vmn2r74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Vmn2r74 APN 7 85,606,338 (GRCm39) missense probably benign 0.03
IGL00904:Vmn2r74 APN 7 85,606,788 (GRCm39) missense probably benign 0.05
IGL01285:Vmn2r74 APN 7 85,606,692 (GRCm39) missense possibly damaging 0.54
IGL01300:Vmn2r74 APN 7 85,606,414 (GRCm39) missense probably benign 0.00
IGL01410:Vmn2r74 APN 7 85,610,500 (GRCm39) missense possibly damaging 0.83
IGL01827:Vmn2r74 APN 7 85,606,800 (GRCm39) missense probably benign 0.00
IGL02094:Vmn2r74 APN 7 85,610,669 (GRCm39) missense probably benign 0.01
IGL02252:Vmn2r74 APN 7 85,606,531 (GRCm39) missense probably benign 0.41
IGL02438:Vmn2r74 APN 7 85,601,824 (GRCm39) missense probably damaging 0.98
IGL02554:Vmn2r74 APN 7 85,606,581 (GRCm39) missense probably benign 0.00
IGL03036:Vmn2r74 APN 7 85,601,900 (GRCm39) nonsense probably null
IGL03370:Vmn2r74 APN 7 85,607,265 (GRCm39) missense probably benign
R0115:Vmn2r74 UTSW 7 85,606,564 (GRCm39) missense probably benign 0.00
R0333:Vmn2r74 UTSW 7 85,601,491 (GRCm39) missense probably benign 0.06
R0415:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R0571:Vmn2r74 UTSW 7 85,601,629 (GRCm39) missense probably damaging 1.00
R0626:Vmn2r74 UTSW 7 85,610,517 (GRCm39) nonsense probably null
R0659:Vmn2r74 UTSW 7 85,605,122 (GRCm39) splice site probably benign
R1202:Vmn2r74 UTSW 7 85,610,545 (GRCm39) missense possibly damaging 0.83
R1473:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R1908:Vmn2r74 UTSW 7 85,601,650 (GRCm39) missense probably benign
R2079:Vmn2r74 UTSW 7 85,606,383 (GRCm39) missense probably benign 0.00
R2368:Vmn2r74 UTSW 7 85,610,522 (GRCm39) missense probably benign 0.39
R3782:Vmn2r74 UTSW 7 85,605,322 (GRCm39) missense probably benign 0.01
R3824:Vmn2r74 UTSW 7 85,607,466 (GRCm39) missense probably damaging 1.00
R3977:Vmn2r74 UTSW 7 85,607,345 (GRCm39) missense probably benign 0.01
R4182:Vmn2r74 UTSW 7 85,606,395 (GRCm39) missense possibly damaging 0.87
R4289:Vmn2r74 UTSW 7 85,606,562 (GRCm39) missense probably benign
R4294:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R4645:Vmn2r74 UTSW 7 85,606,317 (GRCm39) missense probably benign
R4646:Vmn2r74 UTSW 7 85,606,782 (GRCm39) missense probably benign 0.42
R4655:Vmn2r74 UTSW 7 85,610,555 (GRCm39) missense probably benign
R4901:Vmn2r74 UTSW 7 85,605,199 (GRCm39) nonsense probably null
R5532:Vmn2r74 UTSW 7 85,601,197 (GRCm39) missense probably benign 0.32
R5642:Vmn2r74 UTSW 7 85,606,588 (GRCm39) missense probably benign 0.00
R5913:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6170:Vmn2r74 UTSW 7 85,606,348 (GRCm39) missense probably benign 0.03
R6232:Vmn2r74 UTSW 7 85,607,498 (GRCm39) missense possibly damaging 0.82
R6238:Vmn2r74 UTSW 7 85,601,280 (GRCm39) missense probably damaging 1.00
R6255:Vmn2r74 UTSW 7 85,601,659 (GRCm39) missense possibly damaging 0.90
R6468:Vmn2r74 UTSW 7 85,610,599 (GRCm39) missense probably benign 0.34
R6732:Vmn2r74 UTSW 7 85,606,758 (GRCm39) missense probably damaging 1.00
R6816:Vmn2r74 UTSW 7 85,610,621 (GRCm39) nonsense probably null
R6836:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.00
R6995:Vmn2r74 UTSW 7 85,606,860 (GRCm39) critical splice acceptor site probably null
R6995:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R7186:Vmn2r74 UTSW 7 85,601,150 (GRCm39) nonsense probably null
R7246:Vmn2r74 UTSW 7 85,605,173 (GRCm39) missense probably benign
R7374:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.02
R7505:Vmn2r74 UTSW 7 85,606,279 (GRCm39) nonsense probably null
R7525:Vmn2r74 UTSW 7 85,610,510 (GRCm39) missense probably benign
R7569:Vmn2r74 UTSW 7 85,601,544 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r74 UTSW 7 85,606,746 (GRCm39) missense probably benign 0.11
R7956:Vmn2r74 UTSW 7 85,605,166 (GRCm39) missense probably benign 0.09
R8119:Vmn2r74 UTSW 7 85,610,690 (GRCm39) start codon destroyed probably null 0.08
R8131:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R8147:Vmn2r74 UTSW 7 85,605,227 (GRCm39) nonsense probably null
R8181:Vmn2r74 UTSW 7 85,605,324 (GRCm39) missense probably damaging 1.00
R8184:Vmn2r74 UTSW 7 85,601,454 (GRCm39) missense probably benign 0.00
R8375:Vmn2r74 UTSW 7 85,601,914 (GRCm39) missense possibly damaging 0.64
R8948:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R8950:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R9033:Vmn2r74 UTSW 7 85,606,414 (GRCm39) missense probably benign
R9342:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R9578:Vmn2r74 UTSW 7 85,606,101 (GRCm39) missense probably benign 0.01
R9607:Vmn2r74 UTSW 7 85,610,619 (GRCm39) missense probably benign 0.02
R9776:Vmn2r74 UTSW 7 85,605,212 (GRCm39) missense possibly damaging 0.70
Z1176:Vmn2r74 UTSW 7 85,604,835 (GRCm39) missense probably damaging 1.00
Z31818:Vmn2r74 UTSW 7 85,604,729 (GRCm39) splice site probably null
Posted On 2015-04-16