Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02349:Vmn2r74'

289402

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r74

Ensembl Gene

ENSMUSG00000090774

Gene Name

vomeronasal 2, receptor 74

Synonyms

EG546980

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL02349

Quality Score

Status

Chromosome

Chromosomal Location

85951867-85961482 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85952516 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 638 (L638P)

Ref Sequence

ENSEMBL: ENSMUSP00000126917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166355]

AlphaFold

E9PW21

Predicted Effect

probably damaging
Transcript: ENSMUST00000166355
AA Change: L638P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: L638P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	467	7.3e-28	PFAM
Pfam:NCD3G	510	562	4.7e-20	PFAM
Pfam:7tm_3	592	830	1.3e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb8	A	G	5: 24,406,464	I484V	probably benign	Het
Acly	C	T	11: 100,519,679	E158K	probably benign	Het
Akap3	T	A	6: 126,860,263	D3E	probably benign	Het
Alg8	A	G	7: 97,379,894	N152S	possibly damaging	Het
Ano7	A	G	1: 93,391,490	T323A	probably benign	Het
Bmp1	T	C	14: 70,507,549	Y252C	possibly damaging	Het
Cacnb3	A	T	15: 98,640,961	K159*	probably null	Het
Capns2	T	A	8: 92,902,062	V193D	probably benign	Het
Cct2	A	G	10: 117,053,139	I48T	probably benign	Het
Cep152	A	G	2: 125,594,956	S555P	probably damaging	Het
Col5a3	T	C	9: 20,772,361	E1533G	unknown	Het
Cyp17a1	A	G	19: 46,667,497	L451P	probably damaging	Het
D1Ertd622e	A	G	1: 97,646,052	L96P	probably damaging	Het
Dgcr8	T	C	16: 18,280,306	E407G	possibly damaging	Het
Dhx57	T	A	17: 80,255,571	N876Y	probably damaging	Het
Dnah7b	T	A	1: 46,099,503	L235*	probably null	Het
Fgfr2	A	G	7: 130,242,606	Y50H	probably damaging	Het
Gars	T	A	6: 55,048,064		probably benign	Het
Gfpt2	A	T	11: 49,807,703	I42F	probably benign	Het
Glcci1	A	G	6: 8,558,581	K35E	probably damaging	Het
Gpatch1	T	A	7: 35,307,255	M163L	probably damaging	Het
Gpr132	T	C	12: 112,852,855	Y117C	probably damaging	Het
Ints1	G	A	5: 139,768,468	P650S	probably damaging	Het
Itga2b	T	C	11: 102,461,363	D464G	probably damaging	Het
Kansl2	C	A	15: 98,529,446	G185C	probably damaging	Het
Kat6b	T	A	14: 21,637,593	M570K	probably damaging	Het
Map3k19	T	A	1: 127,823,769	D615V	possibly damaging	Het
Map3k7cl	A	G	16: 87,556,013		probably benign	Het
Msto1	A	C	3: 88,910,898	S360R	possibly damaging	Het
Myo15b	C	A	11: 115,863,105		probably benign	Het
Nhlrc2	T	C	19: 56,591,719	V428A	possibly damaging	Het
Olfr33	G	A	7: 102,714,126	R96C	probably damaging	Het
Olfr348	A	C	2: 36,787,046	T174P	possibly damaging	Het
Olfr470	A	G	7: 107,845,605	S43P	probably benign	Het
Olfr568	A	T	7: 102,877,909	Y263F	probably benign	Het
Olfr61	T	C	7: 140,638,471	F257L	probably benign	Het
Olfr874	T	A	9: 37,746,206	M24K	probably benign	Het
Pcm1	G	T	8: 41,288,155		probably null	Het
Plekhg3	A	T	12: 76,562,300	N149I	probably damaging	Het
Rbp3	C	A	14: 33,955,719	H541Q	probably damaging	Het
Rgp1	T	C	4: 43,581,236		probably null	Het
Scyl2	A	T	10: 89,657,938		probably benign	Het
Tas2r144	A	C	6: 42,216,076	H250P	probably benign	Het
Tmppe	T	C	9: 114,405,200	V189A	probably benign	Het
Trp53bp1	G	A	2: 121,199,074	S1875L	probably damaging	Het
Txnl4a	T	A	18: 80,218,729	L60H	probably damaging	Het
Upp2	A	G	2: 58,777,886	D217G	probably benign	Het
Vnn1	A	G	10: 23,898,503	N148S	possibly damaging	Het
Xrcc1	C	T	7: 24,567,042	Q241*	probably null	Het
Zfp990	A	G	4: 145,530,877		probably benign	Het

Other mutations in Vmn2r74

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Vmn2r74	APN	7	85957130	missense	probably benign	0.03
IGL00904:Vmn2r74	APN	7	85957580	missense	probably benign	0.05
IGL01285:Vmn2r74	APN	7	85957484	missense	possibly damaging	0.54
IGL01300:Vmn2r74	APN	7	85957206	missense	probably benign	0.00
IGL01410:Vmn2r74	APN	7	85961292	missense	possibly damaging	0.83
IGL01827:Vmn2r74	APN	7	85957592	missense	probably benign	0.00
IGL02094:Vmn2r74	APN	7	85961461	missense	probably benign	0.01
IGL02252:Vmn2r74	APN	7	85957323	missense	probably benign	0.41
IGL02438:Vmn2r74	APN	7	85952616	missense	probably damaging	0.98
IGL02554:Vmn2r74	APN	7	85957373	missense	probably benign	0.00
IGL03036:Vmn2r74	APN	7	85952692	nonsense	probably null
IGL03370:Vmn2r74	APN	7	85958057	missense	probably benign
R0115:Vmn2r74	UTSW	7	85957356	missense	probably benign	0.00
R0333:Vmn2r74	UTSW	7	85952283	missense	probably benign	0.06
R0415:Vmn2r74	UTSW	7	85961410	missense	probably damaging	1.00
R0571:Vmn2r74	UTSW	7	85952421	missense	probably damaging	1.00
R0626:Vmn2r74	UTSW	7	85961309	nonsense	probably null
R0659:Vmn2r74	UTSW	7	85955914	splice site	probably benign
R1202:Vmn2r74	UTSW	7	85961337	missense	possibly damaging	0.83
R1473:Vmn2r74	UTSW	7	85961410	missense	probably damaging	1.00
R1908:Vmn2r74	UTSW	7	85952442	missense	probably benign
R2079:Vmn2r74	UTSW	7	85957175	missense	probably benign	0.00
R2368:Vmn2r74	UTSW	7	85961314	missense	probably benign	0.39
R3782:Vmn2r74	UTSW	7	85956114	missense	probably benign	0.01
R3824:Vmn2r74	UTSW	7	85958258	missense	probably damaging	1.00
R3977:Vmn2r74	UTSW	7	85958137	missense	probably benign	0.01
R4182:Vmn2r74	UTSW	7	85957187	missense	possibly damaging	0.87
R4289:Vmn2r74	UTSW	7	85957354	missense	probably benign
R4294:Vmn2r74	UTSW	7	85957416	missense	probably benign	0.14
R4645:Vmn2r74	UTSW	7	85957109	missense	probably benign
R4646:Vmn2r74	UTSW	7	85957574	missense	probably benign	0.42
R4655:Vmn2r74	UTSW	7	85961347	missense	probably benign
R4901:Vmn2r74	UTSW	7	85955991	nonsense	probably null
R5532:Vmn2r74	UTSW	7	85951989	missense	probably benign	0.32
R5642:Vmn2r74	UTSW	7	85957380	missense	probably benign	0.00
R5913:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6039:Vmn2r74	UTSW	7	85958318	critical splice acceptor site	probably null
R6039:Vmn2r74	UTSW	7	85958318	critical splice acceptor site	probably null
R6170:Vmn2r74	UTSW	7	85957140	missense	probably benign	0.03
R6232:Vmn2r74	UTSW	7	85958290	missense	possibly damaging	0.82
R6238:Vmn2r74	UTSW	7	85952072	missense	probably damaging	1.00
R6255:Vmn2r74	UTSW	7	85952451	missense	possibly damaging	0.90
R6468:Vmn2r74	UTSW	7	85961391	missense	probably benign	0.34
R6732:Vmn2r74	UTSW	7	85957550	missense	probably damaging	1.00
R6816:Vmn2r74	UTSW	7	85961413	nonsense	probably null
R6836:Vmn2r74	UTSW	7	85957422	missense	probably benign	0.00
R6995:Vmn2r74	UTSW	7	85952735	missense	probably benign	0.01
R6995:Vmn2r74	UTSW	7	85957652	critical splice acceptor site	probably null
R7186:Vmn2r74	UTSW	7	85951942	nonsense	probably null
R7246:Vmn2r74	UTSW	7	85955965	missense	probably benign
R7374:Vmn2r74	UTSW	7	85957422	missense	probably benign	0.02
R7505:Vmn2r74	UTSW	7	85957071	nonsense	probably null
R7525:Vmn2r74	UTSW	7	85961302	missense	probably benign
R7569:Vmn2r74	UTSW	7	85952336	missense	probably damaging	0.99
R7644:Vmn2r74	UTSW	7	85957538	missense	probably benign	0.11
R7956:Vmn2r74	UTSW	7	85955958	missense	probably benign	0.09
R8119:Vmn2r74	UTSW	7	85961482	start codon destroyed	probably null	0.08
R8131:Vmn2r74	UTSW	7	85952735	missense	probably benign	0.01
R8147:Vmn2r74	UTSW	7	85956019	nonsense	probably null
R8181:Vmn2r74	UTSW	7	85956116	missense	probably damaging	1.00
R8184:Vmn2r74	UTSW	7	85952246	missense	probably benign	0.00
R8375:Vmn2r74	UTSW	7	85952706	missense	possibly damaging	0.64
R8948:Vmn2r74	UTSW	7	85957361	missense	probably damaging	1.00
R8950:Vmn2r74	UTSW	7	85957361	missense	probably damaging	1.00
R9033:Vmn2r74	UTSW	7	85957206	missense	probably benign
R9342:Vmn2r74	UTSW	7	85957416	missense	probably benign	0.14
R9578:Vmn2r74	UTSW	7	85956893	missense	probably benign	0.01
R9607:Vmn2r74	UTSW	7	85961411	missense	probably benign	0.02
R9776:Vmn2r74	UTSW	7	85956004	missense	possibly damaging	0.70
Z1176:Vmn2r74	UTSW	7	85955627	missense	probably damaging	1.00
Z31818:Vmn2r74	UTSW	7	85955521	splice site	probably null

Posted On

2015-04-16